Tetrahedron, Journal Year: 2024, Volume and Issue: unknown, P. 134408 - 134408
Published: Dec. 1, 2024
Language: Английский
Tetrahedron, Journal Year: 2024, Volume and Issue: unknown, P. 134408 - 134408
Published: Dec. 1, 2024
Language: Английский
Bioorganic & Medicinal Chemistry Letters, Journal Year: 2025, Volume and Issue: 119, P. 130096 - 130096
Published: Jan. 9, 2025
Language: Английский
Citations
2Organic Letters, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 25, 2024
A concise synthesis of trifluoromethyl (CF
Language: Английский
Citations
5Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 16, 2024
Abstract An efficient Rh(III)‐catalyzed C−H bond activation/cyclization of 2‐arylbenzimidazoles with CF 3 ‐imidoyl sulfoxonium ylides has been achieved, yielding diverse − and amino‐disubstituted 5,6‐dihydrobenzoimidazo[2,1‐ a ]isoquinolines, which could undergo deaminative hydroxylation to access hydroxy‐disubstituted ]isoquinolines catalyzed by Sc(OTf) . This developed strategy features easily available starting materials, broad substrate scope, good scalability high efficiency. Moreover, the antitumor activities selected products against some human cancer cell lines were also investigated, results indicated that several show antiproliferative activities.
Language: Английский
Citations
4Molecules, Journal Year: 2025, Volume and Issue: 30(1), P. 183 - 183
Published: Jan. 5, 2025
An efficient Rh(III)-catalyzed C-H activation of azobenzenes and subsequent [4+1] cascade annulation with CF3-imidoyl sulfoxonium ylides was developed, yielding diverse CF3-indazoles. This protocol featured easily available starting materials, excellent functional group tolerance high efficiency. Moreover, the antitumor activities selected CF3-indazoles against human cancer cell lines were also studied, results indicated that several compounds displayed considerable antiproliferative activities.
Language: Английский
Citations
0Organic Letters, Journal Year: 2025, Volume and Issue: 27(2), P. 657 - 662
Published: Jan. 7, 2025
A condition-controlled Rh(III)-catalyzed selective synthesis of CF3-substituted indoles and pyrido[2,1-a]isoindoles from 2-arylpyridines CF3-imidoyl sulfoxonium ylides has been developed. The Cp*Rh(MeCN)3(SbF6)2/HFIP system afforded via triple C–H activation, while the [Cp*RhCl2]2/MeCN condition selectively furnished through [4 + 1] annulation. notable advantages this developed method included readily available starting materials, broad substrate scope, excellent chemoselectivity. Importantly, several selected products showed promising antitumor activities.
Language: Английский
Citations
0The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 26, 2025
The first example of heterogeneous photoredox-catalyzed fluoroalkylation 4H-pyrido[1,2-a]pyrimidin-4-ones has been developed. With low-cost commercial g-C3N4 as the recyclable photocatalyst and cheap sodium fluoroalkyl sulfonates source, a variety fluoroalkylated pyridopyrimidinones were constructed in moderate to high yields. present reaction can be easily scaled up with good efficiency, catalytic system reused 5 times slight loss activities. Furthermore, biological activity synthesized compounds was preliminarily investigated.
Language: Английский
Citations
0Organic Letters, Journal Year: 2025, Volume and Issue: unknown
Published: March 11, 2025
The carbodiimide anions which were generated in situ from N-cyano-N-aryl-p-toluenesulfonamides (NCTS) the presence of base participated annulations that remain less reported to date. Herein, we have developed for first time an efficient and environmentally friendly [4 + 2] annulation reaction CF3-substituted hetero-1,3-dienes with NCTS synthesis 4H-1,3-oxazines 2-aminopyrimidines under transition-metal-free conditions. methodology demonstrates advantages readily available substrates, simple operation, good functional group tolerance, broad substrate scope, providing a promising route structurally diverse scaffolds. products followed by transformations provide facile TAS2R14 agonist analogues.
Language: Английский
Citations
0Tetrahedron Letters, Journal Year: 2024, Volume and Issue: unknown, P. 155438 - 155438
Published: Dec. 1, 2024
Language: Английский
Citations
1Tetrahedron, Journal Year: 2024, Volume and Issue: unknown, P. 134408 - 134408
Published: Dec. 1, 2024
Language: Английский
Citations
0