Phthalimidine Synthesis via Iridium-Catalyzed Reductive Lactamization DOI
Jingyu Zhang, Chen Yang, Jiaxi Xu

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 24, 2024

Herein, we report a sustainable and efficient method for the synthesis of structurally diverse phthalimidines from 2-formylbenzoic acid primary amines using an iridium-catalyzed reductive lactamization strategy. The advantages this method, such as use water–ethanol solvent, broad substrate scope, high catalyst efficiency (S/C up to 10000), good scalability, easy purification, enable it be practical approach phthalimidines. It is suggested that iridium hydride formation involved in rate-limiting step. Synthetic applications late-stage functionalization medicinally relevant molecules are also demonstrated.

Language: Английский

Photocatalytic Consecutive Photoinduced Electron Transfer-Enabled C(sp3)–H Pyridylation of Dihydroquinoxalin-2-ones DOI
Changduo Pan, Dongdong Chen

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

A photocatalytic decyanative C(sp3)–H pyridination of dihydroquinoxalin-2-ones with 4-cyanopyridines was developed by utilizing 4CzIPN as the photocatalyst. Mechanism studies show that this organophotocatalytic direct undergoes a radical–radical cross-coupling pathway promoted consecutive photoinduced electron transfer.

Language: Английский

Citations

0
Phthalimidine Synthesis via Iridium-Catalyzed Reductive Lactamization DOI
Jingyu Zhang, Chen Yang, Jiaxi Xu

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 24, 2024

Herein, we report a sustainable and efficient method for the synthesis of structurally diverse phthalimidines from 2-formylbenzoic acid primary amines using an iridium-catalyzed reductive lactamization strategy. The advantages this method, such as use water–ethanol solvent, broad substrate scope, high catalyst efficiency (S/C up to 10000), good scalability, easy purification, enable it be practical approach phthalimidines. It is suggested that iridium hydride formation involved in rate-limiting step. Synthetic applications late-stage functionalization medicinally relevant molecules are also demonstrated.

Language: Английский

Citations

0