Radical-Initiated Dearomative Annulation of Tryptamine-Derived Isocyanides: Selective Synthesis of CF₃-Substituted β-Aza-spiroindolines and β-Carbolines

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(21), P. 15979 - 15989

Published: Oct. 22, 2024

A mild approach for synthesizing CF3-substituted β-aza-spiroindolines and β-carbolines from tryptamine-derived isocyanides via site-selective radical annulations has been reported. The crucial role of C2 substituents in the selective annulation process clarified. shows good generality practical applicability, highlighting its effectiveness versatility.

Language: Английский

Visible light-driven and substrate-promoted alkenyltrifluoromethylation of alkenes to synthesize CF3-functionalized 1,4-naphthoquinones

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

The first example of the visible light-driven and substrate-promoted three-component alkenyltrifluoromethylation alkenes is developed. This approach uses easily available alkenes, 2-arylamino-1,4-naphthoquinones Togni reagent as reactants, describes good functionality tolerance. reaction offers a precise synthesis valuable CF

Language: Английский