Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: June 5, 2025

α-Amidation of carbonyl-containing compounds without prefunctionalization starting materials represents a continuing challenge within the scientific community. Here, nickelocene is used catalytically to effect an amidation β-keto esters. Broad substrate tolerance on both coupling partners achieved, enabling application toward convergent synthetic strategy. Initial mechanistic investigations suggest complex activation pathways.

Language: Английский