Site-Selective Electrophilic Trifluoromethylthiolation for the Synthesis of C5- or C7-SCF3-Substituted Indolines DOI
Xiaolong Wang, Yan Fu,

Zhenshan Guo

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

We report herein an efficient and site-selective electrophilic trifluoromethylthiolation of indolines. In the absence any catalyst or additive, C5-selective could proceed at room temperature. With palladium used as catalyst, selectivity was reversed completely, giving C7-selecive trifluoromethylthiolated products. This reaction features good functional group tolerance, simple operation, mild conditions, scale-up application. The potential utilities products were shown by further transformations.

Language: Английский

Site-Selective Electrophilic Trifluoromethylthiolation for the Synthesis of C5- or C7-SCF3-Substituted Indolines DOI
Xiaolong Wang, Yan Fu,

Zhenshan Guo

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

We report herein an efficient and site-selective electrophilic trifluoromethylthiolation of indolines. In the absence any catalyst or additive, C5-selective could proceed at room temperature. With palladium used as catalyst, selectivity was reversed completely, giving C7-selecive trifluoromethylthiolated products. This reaction features good functional group tolerance, simple operation, mild conditions, scale-up application. The potential utilities products were shown by further transformations.

Language: Английский

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