Calcium‐Catalyzed Multicomponent Reactions in Organic Synthesis DOI
Abhishek Pareek, Ravikrishna Dada, Srinivasarao Yaragorla

et al.

Asian Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 19, 2025

Abstract Calcium catalysis has garnered significant attention from synthetic organic chemists as a sustainable alternative to Lewis acidic transition metals, rare‐earth and strong Brønsted acids. This alkaline earth metal, abundant in nature, environmentally benign, moisture‐tolerant, biodegradable, low toxicity, offers distinct advantages. catalysts exhibit exceptional proficiency activating diverse functional groups, particularly π‐activated species such ketones, alcohols, enamines, aldehydes, alkenes, alkynes, allenes, thereby enabling nucleophilic additions tandem chemical transformations. These characteristics resonate with the core tenets of green chemistry, enhancing atom step economy while minimizing waste generation. review presents thorough in‐depth analysis calcium‐catalyzed multi‐component reactions (MCRs), underscoring their transformative role advancing synthesis. Furthermore, it explores untapped potential calcium broadening horizons MCRs, fostering innovative eco‐friendly methodologies for applications pharmaceuticals materials science. Key challenges future prospects within this evolving domain are also critically examined.

Language: Английский

Arylation of α‐Imino Ketones and their Cyclization with Allenoates: Direct Access to Sterically Hindered Pyrroles DOI Open Access
Srinivasarao Yaragorla,

Doma Arun

Asian Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Herein, we report a calcium‐catalyzed, one‐pot, four‐component reaction to synthesize diversely substituted pyrroles. This atom‐economy involves sequence of reactions that proceed via in situ formation α ‐ imino ketones, Friedel‐Crafts arylation, aza‐cyclization, and aromatization the single pot. The showed broad substrate scope with good yields. We demonstrated gram‐scale synthesis post‐synthetic modifications.

Language: Английский

Citations

1
Calcium‐Catalyzed Multicomponent Reactions in Organic Synthesis DOI
Abhishek Pareek, Ravikrishna Dada, Srinivasarao Yaragorla

et al.

Asian Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 19, 2025

Abstract Calcium catalysis has garnered significant attention from synthetic organic chemists as a sustainable alternative to Lewis acidic transition metals, rare‐earth and strong Brønsted acids. This alkaline earth metal, abundant in nature, environmentally benign, moisture‐tolerant, biodegradable, low toxicity, offers distinct advantages. catalysts exhibit exceptional proficiency activating diverse functional groups, particularly π‐activated species such ketones, alcohols, enamines, aldehydes, alkenes, alkynes, allenes, thereby enabling nucleophilic additions tandem chemical transformations. These characteristics resonate with the core tenets of green chemistry, enhancing atom step economy while minimizing waste generation. review presents thorough in‐depth analysis calcium‐catalyzed multi‐component reactions (MCRs), underscoring their transformative role advancing synthesis. Furthermore, it explores untapped potential calcium broadening horizons MCRs, fostering innovative eco‐friendly methodologies for applications pharmaceuticals materials science. Key challenges future prospects within this evolving domain are also critically examined.

Language: Английский

Citations

0