Organocatalytic Packed-Bed Reactors for the Enantioselective Flow Synthesis of Quaternary Isotetronic Acids by Direct Aldol Reactions of Pyruvates
Molecules,
Journal Year:
2025,
Volume and Issue:
30(2), P. 296 - 296
Published: Jan. 13, 2025
The
utilization
of
the
homogeneous
(S)-2-pyrrolidine-tetrazole
organocatalyst
(Ley
catalyst)
in
self-condensation
ethyl
pyruvate
and
cross-aldol
reactions
donor
with
non-enolizable
acceptors,
namely
sterically
hindered
3-methyl-2-oxobutyrate
or
highly
electrophilic
methyl
3,3,3-trifluoropyruvate,
is
described
as
key
enantioselective
step
toward
synthesis
corresponding
biologically
relevant
isotetronic
acids
featuring
a
quaternary
carbon
functionalized
ester
alkyl
groups.
transition
from
to
heterogeneous
flow
conditions
also
investigated,
detailing
fabrication
operation
packed-bed
reactors
filled
silica-supported
version
pyrrolidine-tetrazole
catalyst
(SBA-15
matrix).
Language: Английский
Asymmetric Mannich reactions of α-ketoesters catalyzed through noncovalent interactions: Differences between pyruvates and substituted pyruvates in the formation of nucleophilic species
Tetrahedron Letters,
Journal Year:
2025,
Volume and Issue:
unknown, P. 155514 - 155514
Published: Feb. 1, 2025
Language: Английский