Compelling Evidence: A Critical Update on the Therapeutic Potential of Carbon Monoxide DOI
Nicola Bauer, Qiyue Mao,

Aditi Vashistha

et al.

Medicinal Research Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

ABSTRACT Carbon monoxide (CO) is an endogenous signaling molecule. It produced via heme degradation by oxygenase (HMOX), releasing stoichiometric amounts of CO, iron, and biliverdin (then bilirubin). The HMOX‐CO axis has long been shown to offer beneficial effects modulating inflammation, proliferation cell death as they relate tissue organ protection. Recent years have seen a large number studies examining CO pharmacology, its molecular targets, cellular mechanisms action, pharmacokinetics, detection methods using various delivery modalities including inhaled gas, solutions, types donors. Unfortunately, one widely used donor type includes four commercially available carbonyl complexes with metal or borane, CORM‐2 (Ru 2+ ), CORM‐3 CORM‐A1 (BH 3 CORM‐401 (Mn + which minimal and/or unpredictable production extensive CO‐independent chemical reactivity biological activity. As result, not all “CO activities” in the literature can be attributed CO. In this review, we summarize key findings based on gas solution for certainty active principal avoid data contamination resulting from confirmed potential reactivities activities “carrier” portion CORMs. Along similar line, discuss interesting research areas brain newly proposed CO/HMOX/dopamine role cognitive stimulation circadian rhythm. This review critical future development field steering clear complications caused chemically reactive molecules.

Language: Английский

CO as a potential therapeutic agent: an initial investigation of dosing and concentration dynamics in solution DOI
Dongning Liu, Qiyue Mao, Xiaoxiao Yang

et al.

Medicinal Chemistry Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Language: Английский

Citations

0
Compelling Evidence: A Critical Update on the Therapeutic Potential of Carbon Monoxide DOI
Nicola Bauer, Qiyue Mao,

Aditi Vashistha

et al.

Medicinal Research Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

ABSTRACT Carbon monoxide (CO) is an endogenous signaling molecule. It produced via heme degradation by oxygenase (HMOX), releasing stoichiometric amounts of CO, iron, and biliverdin (then bilirubin). The HMOX‐CO axis has long been shown to offer beneficial effects modulating inflammation, proliferation cell death as they relate tissue organ protection. Recent years have seen a large number studies examining CO pharmacology, its molecular targets, cellular mechanisms action, pharmacokinetics, detection methods using various delivery modalities including inhaled gas, solutions, types donors. Unfortunately, one widely used donor type includes four commercially available carbonyl complexes with metal or borane, CORM‐2 (Ru 2+ ), CORM‐3 CORM‐A1 (BH 3 CORM‐401 (Mn + which minimal and/or unpredictable production extensive CO‐independent chemical reactivity biological activity. As result, not all “CO activities” in the literature can be attributed CO. In this review, we summarize key findings based on gas solution for certainty active principal avoid data contamination resulting from confirmed potential reactivities activities “carrier” portion CORMs. Along similar line, discuss interesting research areas brain newly proposed CO/HMOX/dopamine role cognitive stimulation circadian rhythm. This review critical future development field steering clear complications caused chemically reactive molecules.

Language: Английский

Citations

0