The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 2, 2025

Ligation reactions that proceed at room temperature under aqueous conditions and without catalysts are in high demand, including bioorthogonal reactions. We report a mild amide-ligation reaction of iminophosphoranes with gem-difluoroalkenes. Through experimental theoretical analyses intermolecular intramolecular amidation reactions, we found the Staudinger-Bertozzi ligation-type gem-difluoroalkenes is an excellent proceeds rapidly solvent.

Language: Английский