Rh-Catalyzed Coupling of Cyclic 1,3-Dicarbonyl-Derived Iodonium Ylides with Cyclopropanols DOI

Zongye Wang,

Mingxuan Liang,

Dongyang Zhang

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Herein, we report a modular α-monoalkylation of cyclic 1,3-dicarbonyls with cyclopropyl alcohols through iodonium ylide strategy. This approach is general, base-free, operationally simple, and suitable for various medically important (hetero)cyclic 1,3-dicarbonyls. A wide range alcohols, easily prepared from feedstock chemicals, can serve as complement alkylating agents. Importantly, the newly formed carbonyl groups in resulting products provide versatile platform numerous synthetic applications.

Language: Английский

Rh-Catalyzed Coupling of Cyclic 1,3-Dicarbonyl-Derived Iodonium Ylides with Cyclopropanols DOI

Zongye Wang,

Mingxuan Liang,

Dongyang Zhang

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Herein, we report a modular α-monoalkylation of cyclic 1,3-dicarbonyls with cyclopropyl alcohols through iodonium ylide strategy. This approach is general, base-free, operationally simple, and suitable for various medically important (hetero)cyclic 1,3-dicarbonyls. A wide range alcohols, easily prepared from feedstock chemicals, can serve as complement alkylating agents. Importantly, the newly formed carbonyl groups in resulting products provide versatile platform numerous synthetic applications.

Language: Английский

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