N-Heterocyclic Carbene-Catalyzed [4 + 2] Annulation of Enolizable Thioesters for the Synthesis of 2-Pyrones DOI

Jinfeng Zhang,

Chen Zhu,

Xu Cao

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

An N-heterocyclic carbene (NHC)-catalyzed [4 + 2] annulation enables the direct synthesis of 2-pyrones from α-chlorothioesters and β,γ-unsaturated α-keto esters or chalcones. The method utilizes NHC-activated to generate key intermediates for 2-pyrone formation with high functional group tolerance. Moreover, were transformed into polysubstituted benzene naphthalene derivatives, showcasing their synthetic value.

Language: Английский

N-Heterocyclic Carbene-Catalyzed [4 + 2] Annulation of Enolizable Thioesters for the Synthesis of 2-Pyrones DOI

Jinfeng Zhang,

Chen Zhu,

Xu Cao

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

An N-heterocyclic carbene (NHC)-catalyzed [4 + 2] annulation enables the direct synthesis of 2-pyrones from α-chlorothioesters and β,γ-unsaturated α-keto esters or chalcones. The method utilizes NHC-activated to generate key intermediates for 2-pyrone formation with high functional group tolerance. Moreover, were transformed into polysubstituted benzene naphthalene derivatives, showcasing their synthetic value.

Language: Английский

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