Pd(II)-Catalyzed Annulation of Alkynes with 4-Hydroxy-3-Maleimidecoumarin: One-Pot Construction of Multiple Rings

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

A Pd(II)-catalyzed cascade annulation of 4-hydroxy-3-maleimidecoumarin with alkynes has been demonstrated. This unique strategy highlights an interesting process for the formation three rings (three-, five-, and six-membered) carbocycles heterocycles through spiro-annulation followed by cyclization. offers attractive platform synthesizing various coumarin-fused complex structures in good yields. Additionally, six synthesized compounds have unambiguously confirmed single-crystal X-ray diffraction analysis.

Language: Английский

Pd-Catalyzed Cross-Coupling of Cyclopropanols with 2-Br-p-Quinone Methides/2-Br-Cinnamate Esters Followed by a 1,6- and 1,4-Conjugate Addition Reaction

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

A novel cascade Pd-catalyzed cross-coupling reaction of cyclopropyl alcohol-derived ketone homoenolate with 2-Br-p-quinone methides and 2-Br-cinnamate esters followed by a 1,6- 1,4-conjugate addition is disclosed. This protocol converts various alcohols into homoenolate, which undergoes C-C bond formation 2-Br p-quinone esters. The salient features this methodology include its operational simplicity, mild conditions, an environmentally benign protocol, high efficiency, good to excellent yields, wide substrate scope.

Language: Английский