Facile Synthesis of New Imidazo[4',5':4,5]benzo[1,2-d] isoxazol-6-one Derivatives and In Silico Studies of Their Drug-like Profiles DOI
Maofeng Zhang,

Xing-Li Yan,

Lizhong Wang

et al.

Organic Preparations and Procedures International, Journal Year: 2021, Volume and Issue: 53(4), P. 413 - 421

Published: July 4, 2021

Heterocycles represent a crucial class of organic compounds, in part due to their numerous applications the field drug development. It was found that 85% 104 small molecule drugs appro...

Language: Английский

Metal-free tandem reactions of 2-iodoaryl ynones with sodium azide for the synthesis of benzoisoxazole containing 1,2,3-triazoles DOI
Kashif Majeed, Fengtao Zhou, Qiuyu Zhang

et al.

Organic & Biomolecular Chemistry, Journal Year: 2021, Volume and Issue: 19(16), P. 3707 - 3716

Published: Jan. 1, 2021

Two nitrogen-containing heterocycles were constructed in one pot under metal-free conditions through [3 + 2] azide–alkyne cycloaddition, SNAr azidation and denitrogenative cyclization.

Language: Английский

Citations

5
A transition-metal-free, base-promoted annulation/ring-cleavage/ring-reconstruction cascade reaction: a facile access to N-protection free indole-indenones DOI
Na Luo,

Zhen-Wei Sun,

Xingxin Xu

et al.

Organic Chemistry Frontiers, Journal Year: 2021, Volume and Issue: 8(23), P. 6591 - 6596

Published: Jan. 1, 2021

An unprecedented base-promoted reaction of 2-halogenated arylglyoxals with 2-oxindoles is accomplished under metal-free conditions, furnishing a wide range biologically important ( NH )-indeno[2,1- b ]indol-6(5 H )-ones in useful to good yields.

Language: Английский

Citations

5
Preparation of anthranils via chemoselective oxidative radical cyclization of 3-(2-azidoaryl) substituted propargyl alcohols DOI
Chao Gao, Jian Xu, Shuxian Zhu

et al.

Chemical Communications, Journal Year: 2021, Volume and Issue: 57(16), P. 2037 - 2040

Published: Jan. 1, 2021

In presence of K2S2O8 and HOAc, propargyl alcohols can go oxidative radical cyclizations to give a pool anthranils. Excellent chemoselectivity was seen, the synthesized anthranils be employed as N-nucleophiles in various transformations.

Language: Английский

Citations

4
FeCl3-Catalyzed Three-Component Reaction for the Synthesis β-(1,2,3-Triazolyl)-Ketones by Using DMF as One Carbon Source DOI

Ruilin Fang,

Lei Zheng, Xuyang Chen

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(19), P. 3866 - 3870

Published: Jan. 1, 2024

FeCl 3 -catalyzed oxidative condensation of NH -1,2,3-triazoles and aryl methyl ketones DMF has been reported.

Language: Английский

Citations

0
Acid‐Catalyzed Alkylation of NH‐1,2,3‐Triazoles with Alcohols DOI Open Access
Xuyang Chen,

Zhenwu Yi,

Can Wang

et al.

Asian Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 12(11)

Published: Sept. 8, 2023

Abstract An efficient method for the synthesis of N ‐alkylated 1,2,3‐triazoles from NH ‐1,2,3‐triazoles and alcohols was developed by utilizing Lewis or Brønsted acid as a catalyst. The reaction demonstrates mild conditions, straightforward operation, 92–97 % overall yield. Allylic triphenyl methanol together with 1,1‐diphenylethan‐1‐ol gave single 2 ‐substituted products, while regioselectivities reactions aryl‐substituted secondary alcohols, including diarylmethanols, 1‐phenylethanol, were controlled electronic effect spatial hindrance ‐1,2,3‐triazoles. Furthermore, tert ‐butanol always low regioselectivites different

Language: Английский

Citations

1
Acenaphtho[1,2‐d][1,2,3]triazole and Its Kuratowski Complex: A π‐Extended Tecton for Supramolecular and Coordinative Self‐Assembly DOI Creative Commons
Katharina Knippen, Daniel Matuszczyk,

Maryana Kraft

et al.

Chemistry - A European Journal, Journal Year: 2021, Volume and Issue: 28(4)

Published: Oct. 29, 2021

π-Extended acenaphtho[1,2-d][1,2,3]triazoles, the unsubstituted Anta-H and its di-tert-butyl derivative Dibanta-H, as well 5,6,7,8-tetrahydro-1H-naphtho[2,3-d][1,2,3]triazole Cybta-H were obtained in concise syntheses. In solid state, Dibanta-H forms an unprecedented hydrogen-bonded cyclic tetrad, stabilized by dispersion interactions of bulky tBu substituents, whereas a triad was found crystal structure Anta-H. These assemblies form infinite slipped stacks crystals. Evidence for analogous self-assembly solution provided low-temperature NMR spectroscopy computational analyses. Kuratowski-type pentanuclear complexes [Zn

Language: Английский

Citations

3
1,2,3-Triazoles DOI
Nuno M. M. Moura, Augusto C. Tomé

Elsevier eBooks, Journal Year: 2021, Volume and Issue: unknown, P. 1 - 77

Published: May 31, 2021

Language: Английский

Citations

2
Five-membered ring systems: with more than one N atom DOI
Larry Yet

Progress in heterocyclic chemistry, Journal Year: 2021, Volume and Issue: unknown, P. 223 - 275

Published: Jan. 1, 2021

Language: Английский

Citations

1
Facile Synthesis of New Imidazo[4',5':4,5]benzo[1,2-d] isoxazol-6-one Derivatives and In Silico Studies of Their Drug-like Profiles DOI
Maofeng Zhang,

Xing-Li Yan,

Lizhong Wang

et al.

Organic Preparations and Procedures International, Journal Year: 2021, Volume and Issue: 53(4), P. 413 - 421

Published: July 4, 2021

Heterocycles represent a crucial class of organic compounds, in part due to their numerous applications the field drug development. It was found that 85% 104 small molecule drugs appro...

Language: Английский

Citations

0