Chemistry - An Asian Journal,
Journal Year:
2021,
Volume and Issue:
16(23), P. 3905 - 3908
Published: Oct. 9, 2021
An
eco-friendly
and
noble-metal-free
formal
[4+2]
cycloaddition
reaction
was
developed
for
the
efficient
synthesis
of
biologically
interesting
poly-substituted
pyridines
from
easily
available
ketones
imines,
whereby
two
sequential
C-C
bonds
are
formed.
The
given
approach
features
a
unique
synthetic
strategy
imines
with
wide
substrate
scope,
good
functional
group
tolerance,
mild
conditions
operational
simplicity,
which
represents
more
direct
pathway
to
synthesize
than
traditional
methods.
Chemical Communications,
Journal Year:
2021,
Volume and Issue:
57(72), P. 9010 - 9028
Published: Jan. 1, 2021
This
feature
article
covers
the
recent
status
on
reactivities
of
α-alkyl
cyclic
N
-sulfonyl
ketimines
as
resourceful
nucleophiles,
targeting
fused
carbo-
and
heterocycles,
aza-arenes
etc
.
In
addition,
mechanistic
studies
have
been
presented.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 28, 2025
An
efficient
Cs2CO3-promoted
and
copper(I)-catalyzed
double
cyclization
of
ortho-nitrochalcones
with
vinyl
malononitriles
for
the
de
novo
access
to
a
variety
tri-
tetra-substituted
acridones
their
fused
derivatives
value-added
CN
group
has
been
developed
first
time.
This
one-pot
operation
proceeds
through
Michael-cyclization-aromatization,
followed
by
regioselective
ipso-amination
via
nucleophilic
aromatic
substitution
(SNAr)
reaction,
resulting
in
two
C═C
bonds
C-N
bond
acridone
ring
synthesis.
economic
strategy
based
on
100%
carbon
atoms
ensures
successive
formation
rings
operation,
good
high
yields,
wide
range
substrates,
tolerance
functionalities.
In
addition,
were
converted
into
several
acridines,
highlighting
synthetic
versatility
usefulness
prepared
derivatives.
Organic & Biomolecular Chemistry,
Journal Year:
2020,
Volume and Issue:
18(7), P. 1337 - 1342
Published: Jan. 1, 2020
A
base-promoted
1,6-addition–cyclization
reaction
of
vinyl
para-quinone
methides
with
cyclic
sulfamidate
imines
in
an
open
atmosphere
is
reported.
This
method
delivers
good
to
high
yields
2,4,6-trisubstituted
pyridines
a
valuable
phenolic
moiety
at
the
C4-position.
Organic Chemistry Frontiers,
Journal Year:
2020,
Volume and Issue:
7(23), P. 3868 - 3873
Published: Jan. 1, 2020
The
dual
alkylation
of
the
C(sp3)–H
bond
cyclic
α-methyl-N-sulfonyl
imine
has
been
achieved
through
piperidine-promoted
cascade
condensation/[1,5]-hydride
transfer/cyclization
from
and
o-aminobenzaldehyde
in
trifluoroethanol.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(6), P. 1782 - 1789
Published: Jan. 1, 2024
An
organocatalytic
domino
reaction
of
β-alkyl
nitroolefins
with
alkylidene
malononitriles
to
give
azetidine
nitrones
good
diastereoselectivities
is
reported.
The
in
situ
-generated
were
transmuted
into
isoxazoles
catalyzed
by
acid.
New Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
48(32), P. 14163 - 14169
Published: Jan. 1, 2024
Efficient
access
to
α-carbolines
was
achieved
via
a
domino
reaction
between
iminoindoles
and
arylidene
malononitriles
using
DABCO/NaHCO
3
as
cooperative
basic
system.
The
synthesized
scaffolds
display
blue
emissions
with
good
quantum
yields.
The Journal of Organic Chemistry,
Journal Year:
2021,
Volume and Issue:
86(9), P. 6888 - 6896
Published: April 13, 2021
A
four-step
quasi
one-pot
procedure
for
the
preparation
of
fully
substituted
nicotinates
from
ketone
enamines
and
4-methylideneisoxazol-5-ones
has
been
developed.
The
reaction
sequence
involves
(1)
with
formation
isoxazole-5-ols,
(2)
their
O-methylation
diazomethane,
(3)
hydrogenative
cleavage
O–N
bond
in
5-methoxyisoxazoles
under
action
Mo(CO)6/H2O
simultaneous
isomerization
condensation
formed
enamines,
dihydropyridines,
(4)
aromatization
latter.
The Journal of Organic Chemistry,
Journal Year:
2021,
Volume and Issue:
86(5), P. 3897 - 3906
Published: Feb. 17, 2021
A
one-pot,
four-component
annulation
of
2,3,4,6-tetraarylpyridines
from
aromatic
aldehydes,
methyl
ketones,
diaryl
ethanones,
and
ammonium
acetate
is
described.
The
reaction
features
high
functional
group
compatibility
in
air
under
solvent-free
conditions
without
any
additive
only
water
as
the
nontoxic
byproduct,
providing
a
strategy
for
facile,
economical,
eco-friendly
construction
multiaryl-substituted
pyridines
simple
readily
available
reactants.
Organic & Biomolecular Chemistry,
Journal Year:
2021,
Volume and Issue:
19(16), P. 3595 - 3600
Published: Jan. 1, 2021
An
organophotocatalyzed
C(sp2)-H/N-H
cross-dehydrogenative
coupling
of
cyclic
aldimines
with
aliphatic
amines
has
been
developed,
which
represents
the
first
example
visible-light-induced
C-H
amination
N-sulfonylated
imines.
This
methodology
enables
streamline
assembly
amine
derivatives
via
radical
mediated
C-N
bond
formation.
The
current
protocol
features
transition-metal-free,
mild
conditions,
good
functional
group
tolerance
and
yields.
