Selective phase separation of transcription factors is driven by orthogonal molecular grammar DOI Creative Commons
Mark D. Driver, Patrick R. Onck

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 31, 2025

Protein production is critically dependent on gene transcription rates, which are regulated by RNA polymerase and a large collection of different factors (TFs). How these selectively address genes only partially known. Recent discoveries show that the differential condensation separate TF families through phase separation may contribute to selectivity. Here we this conducting studies six TFs from three with residue-scale coarse-grained molecular dynamics simulations. Our exploration ternary diagrams reveals four dominant sticker motifs two orthogonal driving forces dictate resultant condensate morphology, pointing sequence-dependent grammar as generic mechanism drives selective transcriptional in expression. Transcription factor (TF) rates. Exploration morphology.

Language: Английский

Selective phase separation of transcription factors is driven by orthogonal molecular grammar DOI Creative Commons
Mark D. Driver, Patrick R. Onck

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 31, 2025

Protein production is critically dependent on gene transcription rates, which are regulated by RNA polymerase and a large collection of different factors (TFs). How these selectively address genes only partially known. Recent discoveries show that the differential condensation separate TF families through phase separation may contribute to selectivity. Here we this conducting studies six TFs from three with residue-scale coarse-grained molecular dynamics simulations. Our exploration ternary diagrams reveals four dominant sticker motifs two orthogonal driving forces dictate resultant condensate morphology, pointing sequence-dependent grammar as generic mechanism drives selective transcriptional in expression. Transcription factor (TF) rates. Exploration morphology.

Language: Английский

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