A comparative study on epidemiological characteristics, transmissibility, and pathogenicity of three COVID-19 outbreaks caused by different variants

International Journal of Infectious Diseases, Journal Year: 2023, Volume and Issue: 134, P. 78 - 87

Published: Feb. 1, 2023

The Omicron BA.2 variant is probably the main epidemic strain worldwide at present. Comparing epidemiological characteristics, transmissibility, and influencing factors of SARS-CoV-2, results obtained in this paper will help to provide theoretical support for disease control.This study was a historical information analysis, using R programming language SPSS 24.0 statistical analysis. Geoda Arc GIS were used spatial autocorrelation analysis.Local autocorrelations incidence rate observed Delta BA.1 outbreaks, whereas outbreaks showed random distribution rate. time-dependent reproduction number Delta, BA.1, 3.21, 4.29, 2.96, respectively, correspondingly, mean serial interval 4.29 days (95% confidence [CI]: 0.37-8.21), 3.84 CI: 0-8.37), 2.77 0-5.83). asymptomatic infection cases 21.71%, 6.25%, 4.35%, respectively.The had greatest interval, transmission speed, followed by then Delta. Compared with variants, may be less pathogenic more difficult control than

Language: Английский

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Rapid response to fast viral evolution using AlphaFold 3-assisted topological deep learning

Virus Evolution, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 1, 2025

The fast evolution of SARS-CoV-2 and other infectious viruses poses a grand challenge to the rapid response in terms viral tracking, diagnostics, design manufacture monoclonal antibodies (mAbs) vaccines, which are both time-consuming costly. This underscores need for efficient computational approaches. Recent advancements, like topological deep learning (TDL), have introduced powerful tools forecasting emerging dominant variants, yet they require mutational scanning (DMS) surface proteins associated three-dimensional (3D) protein-protein interaction (PPI) complex structures. We propose an AlphaFold 3 (AF3)-assisted multi-task Laplacian (MT-TopLap) strategy address this need. MT-TopLap combines with TDA models, such as persistent Laplacians (PL) extract detailed geometric characteristics PPIs, thereby enhancing prediction DMS binding free energy (BFE) changes upon virus mutations. Validation four experimental datasets spike receptor-binding domain (RBD) human angiotensin-converting enzyme-2 (ACE2) complexes indicates that our AF3-assisted maintains robust performance, only average 1.1% decrease Pearson correlation coefficients (PCC) 9.3% increase root mean square errors (RMSE), compared use Additionally, achieved PCC 0.81 when tested HK.3 variant dataset, confirming its capability accurately predict BFE adapt new data, showcasing potential effective evolution.

Language: Английский

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Research Progress on the Structure and Function, Immune Escape Mechanism, Antiviral Drug Development Methods, and Clinical Use of SARS-CoV-2 Mpro

Molecules, Journal Year: 2025, Volume and Issue: 30(2), P. 351 - 351

Published: Jan. 16, 2025

The three-year COVID-19 pandemic ‘has’ caused a wide range of medical, social, political, and financial implications. Since the end 2020, various mutations variations in SARS-CoV-2 strains, along with immune escape phenomenon, have emerged. There is an urgent need to identify relatively stable target for development universal vaccines drugs that can effectively combat both strains their mutants. Currently, main focus treating lies disrupting virus’s life cycle. protease (Mpro) closely associated virus replication maturation plays crucial role early stages infection. Consequently, it has become important SARS-CoV-2-specific drugs. This review summarizes recent research progress on novel coronavirus’s proteases, including pivotal Mpro cycle, structure catalytic mechanism Mpro, self-maturation escape, current methods developing antiviral targeting key successfully entered clinical trials. aim provide researchers involved systematic comprehensive information.

Language: Английский

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The Recombinant Immunodominant Regions 179-344 and 550-670 from SARS-COV2 Spike protein can efficiently react with patients' sera

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107604 - 107604

Published: April 1, 2025

Language: Английский

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Letter to the editor: Epidemiology of the SARS-CoV-2 variant Omicron BA.2 – vigilance needed

Eurosurveillance, Journal Year: 2022, Volume and Issue: 27(13)

Published: March 31, 2022

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Language: Английский

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