Synthesis of Original Cyclic Dinucleotide Analogues Using the Sulfo-click Reaction DOI
Romain Amador, Jean‐Jacques Vasseur, Gabriel Birkuš

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(4), P. 819 - 823

Published: Jan. 18, 2024

The stimulator of interferon genes (STING) protein plays a crucial role in the activation innate immune response. Activation STING is initiated by cyclic dinucleotides (CDNs) which prompted community to synthesize structural analogues enhance their biological properties. We present here synthesis and evaluation four novel CDN composed an N-acylsulfonamide linkage. These CDNs were obtained high overall yields via sulfo-click reaction as key step.

Language: Английский

Epigenetic Control of Innate Immunity: Consequences of Acute Respiratory Virus Infection DOI Creative Commons
Rivka Bella Lefkowitz, Clare M. Miller,

Juan David Martinez-Caballero

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(2), P. 197 - 197

Published: Jan. 27, 2024

Infections caused by acute respiratory viruses induce a systemic innate immune response, which can be measured the increased levels of expression inflammatory genes in cells. There is growing evidence that these viral infections, alongside transient transcriptomic responses, epigenetic remodeling as part such DNA methylation and histone modifications, might persist after infection cleared. In this article, we first review primary mechanisms context immunity inflammation, are crucial for regulation response to infections. Next, delve into existing knowledge concerning impact virus infections on epigenome, focusing Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Influenza A Virus (IAV), Syncytial (RSV). Finally, offer perspectives potential consequences virus-induced open questions field currently under investigation.

Language: Английский

Citations

10

Synthesis of Original Cyclic Dinucleotide Analogues Using the Sulfo-click Reaction DOI
Romain Amador, Jean‐Jacques Vasseur, Gabriel Birkuš

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(4), P. 819 - 823

Published: Jan. 18, 2024

The stimulator of interferon genes (STING) protein plays a crucial role in the activation innate immune response. Activation STING is initiated by cyclic dinucleotides (CDNs) which prompted community to synthesize structural analogues enhance their biological properties. We present here synthesis and evaluation four novel CDN composed an N-acylsulfonamide linkage. These CDNs were obtained high overall yields via sulfo-click reaction as key step.

Language: Английский

Citations

1