Epigenetic Control of Innate Immunity: Consequences of Acute Respiratory Virus Infection
Viruses,
Journal Year:
2024,
Volume and Issue:
16(2), P. 197 - 197
Published: Jan. 27, 2024
Infections
caused
by
acute
respiratory
viruses
induce
a
systemic
innate
immune
response,
which
can
be
measured
the
increased
levels
of
expression
inflammatory
genes
in
cells.
There
is
growing
evidence
that
these
viral
infections,
alongside
transient
transcriptomic
responses,
epigenetic
remodeling
as
part
such
DNA
methylation
and
histone
modifications,
might
persist
after
infection
cleared.
In
this
article,
we
first
review
primary
mechanisms
context
immunity
inflammation,
are
crucial
for
regulation
response
to
infections.
Next,
delve
into
existing
knowledge
concerning
impact
virus
infections
on
epigenome,
focusing
Severe
Acute
Respiratory
Syndrome
Coronavirus
2
(SARS-CoV-2),
Influenza
A
Virus
(IAV),
Syncytial
(RSV).
Finally,
offer
perspectives
potential
consequences
virus-induced
open
questions
field
currently
under
investigation.
Language: Английский
Synthesis of Original Cyclic Dinucleotide Analogues Using the Sulfo-click Reaction
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(4), P. 819 - 823
Published: Jan. 18, 2024
The
stimulator
of
interferon
genes
(STING)
protein
plays
a
crucial
role
in
the
activation
innate
immune
response.
Activation
STING
is
initiated
by
cyclic
dinucleotides
(CDNs)
which
prompted
community
to
synthesize
structural
analogues
enhance
their
biological
properties.
We
present
here
synthesis
and
evaluation
four
novel
CDN
composed
an
N-acylsulfonamide
linkage.
These
CDNs
were
obtained
high
overall
yields
via
sulfo-click
reaction
as
key
step.
Language: Английский