Regulatory Mechanisms of Cytotoxicity and Hemocompatibility Induced by Phase Transformation of Kaolinite Nanocarrier DOI
Meng Zheng, Ya Tan,

Yiting Yuan

et al.

The Journal of Physical Chemistry Letters, Journal Year: 2025, Volume and Issue: unknown, P. 3945 - 3953

Published: April 10, 2025

Revealing the regulatory mechanism underlying cytotoxicity and hemocompatibility of nanocarriers is crucial for their biofunctionalized design practical application in nanotherapeutics. However, microstructural physicochemical properties inevitably change during modification process, impact these changes on biosafety remains unclear. Herein, we investigate effects phase transformation kaolinite (Kaol) nanoclay its biosafety. Experimental results indicate that adjoint dehydration, dehydroxylation, disaggregation Kaol could alter mode interaction at cell interface mitigate damage to membranes. Furthermore, heat-treated exhibits reduced hemolysis while maintaining red blood adhesion pro-coagulant functions, without affecting structure plasma proteins. Collectively, this study provide a novel insight into correlation between microstructure

Language: Английский

Regulatory Mechanisms of Cytotoxicity and Hemocompatibility Induced by Phase Transformation of Kaolinite Nanocarrier DOI
Meng Zheng, Ya Tan,

Yiting Yuan

et al.

The Journal of Physical Chemistry Letters, Journal Year: 2025, Volume and Issue: unknown, P. 3945 - 3953

Published: April 10, 2025

Revealing the regulatory mechanism underlying cytotoxicity and hemocompatibility of nanocarriers is crucial for their biofunctionalized design practical application in nanotherapeutics. However, microstructural physicochemical properties inevitably change during modification process, impact these changes on biosafety remains unclear. Herein, we investigate effects phase transformation kaolinite (Kaol) nanoclay its biosafety. Experimental results indicate that adjoint dehydration, dehydroxylation, disaggregation Kaol could alter mode interaction at cell interface mitigate damage to membranes. Furthermore, heat-treated exhibits reduced hemolysis while maintaining red blood adhesion pro-coagulant functions, without affecting structure plasma proteins. Collectively, this study provide a novel insight into correlation between microstructure

Language: Английский

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