Cyclodextrin Derivatives as Modulators for Enhanced Drug Delivery from Niosome Membrane: A Fluorescence Correlation Spectroscopy and Isothermal Titration Calorimetry Approach

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Designing efficient drug delivery systems for optimum therapeutic outcomes and minimum adverse effects remains a pivotal focus in pharmaceutical research. Understanding the nature of interactions between drugs carriers drug-release mechanism are key aspects development effective systems. This work presents detailed investigation into intricate niosomes Phenosafranin (PSF), subsequent release induced by variety cyclodextrins (CDs) employing multifaceted approach. Ensemble average spectroscopic single molecular level investigations based on fluorescence correlation spectroscopy (FCS), employed to explore binding PSF with niosome membrane. Subsequently, was studied disrupting structure using various CDs, their efficacy accessed through steady-state time-resolved photophysical responses. FCS experiments provided precise insights process at single-molecule variation translational diffusion characteristics drug. Additionally, isothermal titration calorimetric (ITC) further revealed thermodynamics governing CD-niosome host:guest varying potential different CDs which were validated electron microscopy confocal analyses. A broader analysis prepared nonionic surfactants highlighted influence cavitand size interaction constituents. comprehensive sheds light complex interplay these components interactions, providing applications.

Language: Английский

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Photoinduced Formation and Intercluster Conversion of a Thiol-Templated Copper Nanocluster

ACS Applied Optical Materials, Journal Year: 2024, Volume and Issue: 2(9), P. 1880 - 1890

Published: Aug. 26, 2024

The preparation of metal nanoclusters through light–matter interaction is an unexplored realm nanomaterials research. A comprehensive understanding the stages involved in growth process scant literature. Herein, we report photoinduced formation yellow-emissive copper (Y-CuNCs) from a binuclear complex [Cu2(SPhCl)2(PPh3)4], which was subsequently observed to undergo conversion green-emissive (G-CuNCs). We were able characterize intermediate complexes, fragments, and formed process, attributed precursors for CuNCs. To initially Cu2(SPhCl)2(PPh3)4, irradiation with ultraviolet (UV) light (λ ∼ 365 nm) resulted Y-CuNCs. Further, upon solution Y-CuNCs UV light, convert G-CuNCs via intercluster conversion. both CuNCs has been extensively studied UV–vis absorption features, photoluminescence studies, lifetime measurements. confirmed help transmission electron microscopy images, electrospray ionization mass spectroscopy (ESI-MS) analysis, 31P NMR data analysis. Moreover, plausible mechanism also substantiated ESI-MS

Language: Английский

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Single Source Polychromatic Luminescent and White Emitting Copper Nanoclusters

Advanced Optical Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

Abstract The low cost and fine‐tunability of the luminescence copper nanoclusters make them attractive candidates for opto‐electronic, imaging, sensing applications; their stability, a precise understanding structure–function correlations however, continue to be challenging. A comprehensive chemical etching strategy is developed synthesize orange, blue, cyan emitting from single source ultrasmall nanoparticles; high quantum yields up ≈34% are realized. Steady state time‐resolved spectroscopy, electron microscopy, resolution mass spectrometry, computational modeling provide critical mechanistic insight into polychromatic luminescence. facile method fabrication polymer nanocomposite thin films that sustain stabilize luminescent presented. subtle variation without need admix multiple components, provides white with Commission Internationale de l'éclairage (CIE) coordinates, x = 0.35, y 0.33. highlights this work i) simple solution synthesis stable, uniform, pure Cu nanoparticles, ii) by variations in an optimized protocol produce highly luminescent, nanoclusters, including white‐emitting ones, iii) stabilization bright systems films, iv) detailed analysis tuning.

Language: Английский

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Superstructures of Copper Nanoclusters as NIR TADF Emitters: Solvent-dependent Optical and Morphological Modulation

Nanoscale, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Self-assembled thiol-templated CuNCs display NIR-TADF emission which can be modulated by solvent, accompanied remarkable change in the morphology. The electronic structure of surface ligands also used to tailor properties CuNCs.

Language: Английский

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