Remarkable Insensitivity of Protein Diffusion to Protein Charge DOI

Setare Mostajabi Sarhangi,

Dmitry V. Matyushov

The Journal of Physical Chemistry Letters, Journal Year: 2024, Volume and Issue: 15(37), P. 9502 - 9508

Published: Sept. 11, 2024

Friction to translational diffusion of ionic particles in polar liquids should scale linearly with the squared ion charge, according standard theories. Substantial slowing is expected for proteins water. In contrast, our simulations charge mutants green fluorescent water show remarkable insensitivity constant protein's range charges between -29 and +35. The friction coefficient given as a product force variance memory function relaxation time. We find remarkably accurate equality electrostatic negative cross-correlation van der Waals forces. invariance combined effect time invariances protein charge. temperature dependence highly non-Arrhenius, fragile-to-strong crossover at glass transition.

Language: Английский

Remarkable Insensitivity of Protein Diffusion to Protein Charge DOI

Setare Mostajabi Sarhangi,

Dmitry V. Matyushov

The Journal of Physical Chemistry Letters, Journal Year: 2024, Volume and Issue: 15(37), P. 9502 - 9508

Published: Sept. 11, 2024

Friction to translational diffusion of ionic particles in polar liquids should scale linearly with the squared ion charge, according standard theories. Substantial slowing is expected for proteins water. In contrast, our simulations charge mutants green fluorescent water show remarkable insensitivity constant protein's range charges between -29 and +35. The friction coefficient given as a product force variance memory function relaxation time. We find remarkably accurate equality electrostatic negative cross-correlation van der Waals forces. invariance combined effect time invariances protein charge. temperature dependence highly non-Arrhenius, fragile-to-strong crossover at glass transition.

Language: Английский

Citations

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