Designing Effective Antimicrobial Agents: Structural Insights into the Antibiofilm Activity of Ionic Liquids

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Research concerning biofilm control is critical due to the pervasive and resilient nature of biofilms, which pose significant challenges across industrial, environmental, healthcare sectors. Traditional antimicrobial treatments are often ineffective against these robust structures. Here, we explore properties ionic liquids (ILs) their efficacy in disruption. By examining structural variations ILs, highlight key role hydrophobicity, noting that longer alkyl side chains IL cations enhance disruption bacterial death. However, upon reaching a certain optimal chain length─usually C12 C14─the activity ILs starts decrease. Furthermore, symmetry size anions significantly impact elimination. This Perspective addresses gap research, revealing structure–activity relationships providing foundation for designing more effective biofilm-disrupting agents.

Language: Английский

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Lipid Lateral Diffusion: Mechanisms and Modulators

Soft Matter, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

The lateral diffusion of lipids within a membrane is paramount importance, serving as central mechanism in numerous physiological processes including cell signaling, trafficking, protein activity regulation, and energy transduction pathways. This review offers comprehensive overview lipid model biomembrane systems explored through the lens neutron scattering techniques. We examine diverse models explore various factors influencing this fundamental process dynamics. Additionally, we offer thorough summary how different membrane-active compounds, drugs, antioxidants, stimulants, proteins, affect diffusion. Our analysis unveils intricate interplay between these additives membranes, shedding light on their dynamic interactions. elucidate that interaction governed by complex combination multiple physical state charge membrane, concentration additives, molecular architecture spatial distribution membrane. In conclusion, briefly discuss future directions areas requiring further investigation realm diffusion, highlighting need to study more realistic systems.

Language: Английский

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A Facile Strategy Based on Ionic Liquids to Modulate the Antibacterial, Flame‐Retardant, and Sensing Properties of Cotton Fabrics

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Abstract Surface treatment of textiles causes a significant amount environmental pollution and endowing traditional fabrics with multiple functions through facile methods remains challenging. Here simple strategy is proposed involving the copolymerization methacrylic acid (MA) functionalized cotton fabric (CF) vinyl‐functionalized ionic liquid (IL). The resulting CF‐PIL (where P refers to poly) shows high bacteriostatic reduction rates (BR > 99%), excellent flame retardancy (LOI = 28.1%), together sensitivity quick responsiveness. exhibits unparalleled reliability even after 50 washing cycles. CF‐PIL‐based also captures signals from mechanical stimuli, humidity, temperature. This allows material act as sensor for physiological signal monitoring (breathing, body temperature, external stimulation), high‐temperature. Through design circuit, assembled high‐temperature fire alarm system, which can provide early warning temperatures when near or in contact flames within few seconds. While many applications may be envisaged, particular relevance are intelligent firefighting suits smart architectural textiles.

Language: Английский

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Quantifying Ionic Liquid Affinity and Its Effect on Phospholipid Membrane Structure and Dynamics

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Understanding the interactions between ionic liquids (ILs) and biomembranes is pivotal for uncovering origins of IL-induced biological activities their potential applications in pharmaceuticals. In this study, we investigate influence imidazolium-based ILs on viscoelasticity, dynamics, phase behavior two model membrane systems: (i) lipid monolayers (ii) unilamellar vesicles, both composed dipalmitoylphosphatidylcholine (DPPC). Two different with varying alkyl chain lengths, namely, 1-decyl-3-methylimidazolium bromide (DMIM[Br]) 1-hexyl-3-methylimidazolium (HMIM[Br]) are used to role lengths. Our findings demonstrate that induce significant disorder membranes by altering area per molecule, thereby modulating viscoelastic properties. a longer show stronger membranes, causing more pronounced disorder. Fourier transform infrared spectroscopy indicates IL incorporation shifts membrane's main transition lower temperatures introduces gauche defects, signifying increased structural This effect amplified chains higher concentrations. Quasielastic neutron scattering studies highlight markedly enhance lateral diffusion lipids within leaflet, extent enhancement determined physical state, concentration, length. The most acceleration occurs ordered concentrations longer-chain IL. Molecular dynamics simulations corroborate these experimental findings, showing extensively disrupt organization, introduce increase lipid, consequently diffusion. fluidity permeability provides mechanistic basis observed toxicity associated ILs. These results offer critical insights into molecular-level advancing our understanding toxicological pharmaceutical implications.

Language: Английский

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Investigation on the Formation Mechanism and Antibacterial Activity of Novel Citric Acid-based Ionic Liquids Applied in the Food Field

LWT, Journal Year: 2025, Volume and Issue: 224, P. 117884 - 117884

Published: May 1, 2025

Language: Английский

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Structural Reorganizations and Nanodomain Emergence in Lipid Membranes Driven by Ionic Liquids

Langmuir, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

Ionic liquids (ILs) have promising applications in pharmaceuticals and green chemistry, but their use is limited by toxicity concerns, mainly due to interactions with cell membranes. This study examines the effects of imidazolium-based ILs on microscopic structure phase behavior a model membrane composed zwitterionic dipalmitoylphosphatidylcholine (DPPC) lipids. Small-angle neutron scattering dynamic light reveal that shorter-chain IL, 1-hexyl-3-methylimidazolium bromide (HMIM[Br]), induces aggregation DPPC unilamellar vesicles. In contrast, this absent longer alkyl chain 1-decyl-3-methylimidazolium (DMIM[Br]). Instead, DMIM[Br] incorporation leads formation distinct IL-poor IL-rich nanodomains within membrane, as evidenced X-ray reflectivity, differential scanning calorimetry, molecular dynamics simulations. The less evident nanodomain HMIM[Br] underscores role hydrophobic between lipid tails ILs. Our findings demonstrate chains significantly enhance propensity form nanodomains, which closely linked enhanced permeability, shown dye leakage measurements. heightened permeability likely underlies greater cytotoxicity longer-chain crucial link provides valuable insights for designing safer, more environmentally friendly ILs, promoting biomedical sustainable industrial processes.

Language: Английский

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Anion exchange effect on structural, antibacterial activity and molecular docking of 1-methyl-3-(4-vinylbenzyl) imidazol-3-ium chloride/bis(trifluoromethylsulfonyl)imide/hexaflurophosphate: experimental and DFT approach

Journal of Ionic Liquids, Journal Year: 2024, Volume and Issue: unknown, P. 100115 - 100115

Published: Sept. 1, 2024

Language: Английский

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