Association Between Alpha-1-Acid Glycoprotein and Non-Alcoholic Fatty Liver Disease and Liver Fibrosis in Adult Women DOI Creative Commons
Yansong Fu, Siyi Zhang, Xin Zeng

et al.

Metabolites, Journal Year: 2025, Volume and Issue: 15(4), P. 280 - 280

Published: April 17, 2025

Background: Alpha-1-acid glycoprotein (AGP) is a synthesized mainly by the liver. Nonalcoholic fatty liver disease (NAFLD) and fibrosis (LF) are associated with metabolic disorders. The aim of this study was to examine potential correlation between AGP both NAFLD LF. Methods: data were derived from 2017–2023 National Health Nutrition Examination Survey (NHANES). linear association LF examined multivariate logistic regression models. Non-linear relationships described fitting smoothed curves threshold effect analysis. Subgroup analysis also performed assess regulatory factors. Results: included 2270 females. found be significantly positively [OR = 12.00, 95% CI (6.73, 21.39), p < 0.001] 2.20, (1.07, 4.50), 0.042]. Furthermore, different in diabetic subgroup (p 0.05 for interaction). Additionally, we an inverted U-shaped relationship controlled attenuation parameter (CAP), inflection point at 1.20 g/L. Conclusions: We significant positive LF, there CAP.

Language: Английский

Association Between Alpha-1-Acid Glycoprotein and Non-Alcoholic Fatty Liver Disease and Liver Fibrosis in Adult Women DOI Creative Commons
Yansong Fu, Siyi Zhang, Xin Zeng

et al.

Metabolites, Journal Year: 2025, Volume and Issue: 15(4), P. 280 - 280

Published: April 17, 2025

Background: Alpha-1-acid glycoprotein (AGP) is a synthesized mainly by the liver. Nonalcoholic fatty liver disease (NAFLD) and fibrosis (LF) are associated with metabolic disorders. The aim of this study was to examine potential correlation between AGP both NAFLD LF. Methods: data were derived from 2017–2023 National Health Nutrition Examination Survey (NHANES). linear association LF examined multivariate logistic regression models. Non-linear relationships described fitting smoothed curves threshold effect analysis. Subgroup analysis also performed assess regulatory factors. Results: included 2270 females. found be significantly positively [OR = 12.00, 95% CI (6.73, 21.39), p < 0.001] 2.20, (1.07, 4.50), 0.042]. Furthermore, different in diabetic subgroup (p 0.05 for interaction). Additionally, we an inverted U-shaped relationship controlled attenuation parameter (CAP), inflection point at 1.20 g/L. Conclusions: We significant positive LF, there CAP.

Language: Английский

Citations

0