Responsive Chirality: Tailoring Supramolecular Assemblies with External Stimuli as Future Platforms for Electronic/ Spintronic Materials DOI
Meenal Kataria, Shu Seki

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 27, 2024

Abstract Supramolecular chirality is the major branch of supramolecular chemistry, which not only plays important roles in biological processes but also synthetically designed aggregated systems. To understand complex processing systems, way to design chiral ensembles that mimic natural biomolecules such as Deoxyribonucleic acid (DNA), Ribonucleic (RNA), amino acids, etc. In addition, systems and self‐assemblies molecular motifs with breaking spatial inversion symmetry have been regarded key substances electronics spintronics well fundamental chemistry physics. Here, this review, our concern understanding modulation arrangements packing modes under impact any external stimuli, results tailoring handedness resulted superstructures. We, highlighted role stimuli solvent, chemical additives, photo exposure, altering for their future utility “active switches” optoelectronic spintronic devices applications.

Language: Английский

Differently N‐Capped Analogues of Fmoc‐FF DOI Creative Commons
Carlo Diaferia, Elisabetta Rosa, Enrico Gallo

et al.

Chemistry - A European Journal, Journal Year: 2023, Volume and Issue: 29(28)

Published: March 6, 2023

Short and ultra-short peptides have been recently envisioned as excellent building blocks for the formulation of hydrogels with appealing properties. Due to its simplicity capability gel under physiological conditions, Fmoc-FF (Nα -fluorenylmethoxycarbonyl-diphenylalanine), remains one most studied low molecular-weight hydrogelators. Since first identification in 2006, a plethora analogues were synthetized investigated fabrication novel supramolecular materials. Here we report description which aromatic Fmoc group is replaced other substituents. These are distinguished into five different classes including derivatives: i) customized solid phase peptide synthesis protecting groups; ii) containing non-aromatic groups, iii) iv) derivatized metal complexes v) stimuli-responsive groups. The morphological, mechanical, functional effects caused by this modification on resulting material also pointed out.

Language: Английский

Citations

19
Hierarchical Self‐Assembly of Short Peptides: Nanostructure Formation, Function Tailoring, and Applications DOI Creative Commons
Liangchun Li,

Renlin Zheng,

Rongqin Sun

et al.

Macromolecular Bioscience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

This article explores the hierarchical self-assembly of short peptides, which refers to structured spatial arrangements these molecules over long distances. phenomenon is commonly found in nature and has important implications for biological structure function. Short peptides are preferred because they have ability spontaneously create various nanostructures. process, known as bottom-up assembly, allows addition functional groups at carboxyl or amine ends peptides. These enable specific functions that extremely valuable fields biotechnology biomedicine. text discusses basic processes involved such characteristics amino acid side chains, categorization according their chemical structure, influence intermolecular forces, dynamic process. In addition, paper uses disciplines biomedicine optoelectronics, including stimulus-responsive hydrogels, tissue engineering, drug delivery. The also suggests rational design principles controlling creating new commercial applications, particularly with offers insights into future discipline.

Language: Английский

Citations

0
Chiral helical peptide nanomaterials: Construction strategies and applications DOI
Shiwei Wang, Zhen He,

Xiaolin Duan

et al.

Nano Today, Journal Year: 2025, Volume and Issue: 62, P. 102703 - 102703

Published: March 13, 2025

Language: Английский

Citations

0
Coordination-driven self-assembly of biomolecules and metal ions: Advances in methodology and applications DOI
Yue Su, Yiting Liu, Yu Lin Zhong

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 527, P. 216403 - 216403

Published: Dec. 26, 2024

Language: Английский

Citations

3
Experimental and Computational Study of Injectable Iron(III)/Ultrashort Peptide Hydrogels: A Candidate for Ferroptosis‐Induced Treatment of Bacterial Infections DOI Creative Commons
Capucine Loth, Florent Barbault,

Christelle Guégan

et al.

Small Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Injectable hydrogels are promising candidates as local drug delivery platforms for the treatment of infected wounds. Self‐assembled small peptide interest due to their high biocompatibility, degradability, and ease synthesis. This study describes formation an injectable hydrogel based on self‐assembly Fmoc‐FFpY (Fmoc: fluorenylmethoxycarbonyl, F: phenylalanine, pY: tyrosine phosphate) triggered by electrostatic interactions in presence Fe 3+ ions. Stabilized H bonding π–π stacking, exhibit mechanical stiffness with a G ′ (storage modulus) ≈8000 Pa self‐recovery up ≈100 Pa. Peptide yields β‐sheets twisted into fibrillar helices 12 nm diameter pitch. Molecular dynamics simulations confirm 1) aggregation adopted secondary structure show that 2) aggregated Fmoc‐FFpY/Fe disrupts bacterial membrane Staphylococcus aureus Pseudomonas aeruginosa , favoring passive entry pathogen. In full agreement simulations, antibacterial activity against both bacteria, likely increased cell, resulting enhanced production reactive oxygen species. work paves way ferroptosis‐inducing infections using ultrashort peptides.

Language: Английский

Citations

0
Chiral supramolecular nanomaterials: From chirality transfer and amplification to regulation and applications DOI Creative Commons
Wenrui Chen, Boran Li, Guanbin Gao

et al.

Interdisciplinary materials, Journal Year: 2023, Volume and Issue: 2(5), P. 689 - 713

Published: Sept. 1, 2023

Abstract Chirality is an omnipresent structural feature found in nature. The transfer and amplification of chirality are widely recognized phenomena. In appropriate solvents, chiral molecules can self‐assemble into diverse supramolecular nanomaterials with unique properties. the past two decades, there has been a growing number reported nanomaterials. Significant advancements have made within these materials, as well their regulation applications. Therefore, it essential to summarize progress this field. Here we present comprehensive overview latest nanomaterials, ranging from This review aims deepen our understanding fundamental origins inherent while also providing reference for expanding potential

Language: Английский

Citations

9
Nanomaterials and methods for cancer therapy: 2D materials, biomolecules, and molecular dynamics simulations DOI
Welela Meka Kedir, Lunna Li, Yaw Sing Tan

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Nanomaterials made from 2D semiconductors and biomolecules are reviewed. Cell-nanoparticle interactions examined in recent simulations. These nanomaterials MD simulations reveal novel mechanisms enable cancer drug delivery targeting.

Language: Английский

Citations

2
Hybrid peptide‐PNA monomers as building blocks for the fabrication of supramolecular aggregates DOI

Luca Cimmino,

Carlo Diaferia,

Mariangela Rosa

et al.

Journal of Peptide Science, Journal Year: 2024, Volume and Issue: 30(7)

Published: March 12, 2024

Advantages like biocompatibility, biodegradability and tunability allowed the exploitation of peptides peptidomimetics as versatile therapeutic or diagnostic agents. Because their selectivity towards transmembrane receptors cell membranes, have also been identified suitable molecules able to deliver in vivo macromolecules, proteins nucleic acids. However, after identification homodimer diphenylalanine (FF) an aggregative motif inside Aβ 1–42 polypeptide, short ultrashort studied building blocks for fabrication supramolecular, ordered nanostructures applications biotechnological, biomedical industrial fields. In this perspective, many hybrid that combine FF with other chemical entities synthesized characterized. Two novel derivatives (tFaF cFgF), which is alternated peptide‐nucleic acid (PNA) heterodimer “g‐c” (guanine‐cytosine) “a‐t” (adenine‐thymine) dimeric forms (tFaF) 2 (cFgF) were synthesized. The structural characterization performed by circular dichroism (CD), Fourier transform infrared (FTIR) fluorescence spectroscopies highlighted capability all FF‐PNA self‐assemble into β‐sheet structures. As a consequence supramolecular organization, resulting aggregates exhibit optoelectronic properties already reported similar nanostructures. This photoemissive behavior promising potential bioimaging.

Language: Английский

Citations

1
Responsive Chirality: Tailoring Supramolecular Assemblies with External Stimuli as Future Platforms for Electronic/ Spintronic Materials DOI
Meenal Kataria, Shu Seki

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 27, 2024

Abstract Supramolecular chirality is the major branch of supramolecular chemistry, which not only plays important roles in biological processes but also synthetically designed aggregated systems. To understand complex processing systems, way to design chiral ensembles that mimic natural biomolecules such as Deoxyribonucleic acid (DNA), Ribonucleic (RNA), amino acids, etc. In addition, systems and self‐assemblies molecular motifs with breaking spatial inversion symmetry have been regarded key substances electronics spintronics well fundamental chemistry physics. Here, this review, our concern understanding modulation arrangements packing modes under impact any external stimuli, results tailoring handedness resulted superstructures. We, highlighted role stimuli solvent, chemical additives, photo exposure, altering for their future utility “active switches” optoelectronic spintronic devices applications.

Language: Английский

Citations

1