Selective
detection
of
creatinine
(Ctn)
is
crucial
for
the
clinical
diagnosis
early-stage
kidney
dysfunction.
A
non-enzymatic
electrochemical
method
a
highly
selective
and
sensitive
Ctn
in
synthetic
urine
samples
was
developed
using
an
electrochemically
activated
carbon-coated
paper-based
analytical
device
(ePAD*).
During
activation,
growth
stable
carboxyl
(C=O,
COOH)
groups
on
edge
planes
carbon
surface
observed.
The
prepared
ePAD*
characterized
various
microscopic,
spectroscopic,
techniques.
utilized
as
medium
exchanger,
voltammetric
response
linear
concentration
from
0.03
to
4.5
mM
with
limit
5.41
µM
achieved.
In
addition,
presence
potential
interferences
(i.e.,
uric
acid,
ascorbic
ammonia,
urea)
examined.
examination
revealed
remarkable
selectivity
toward
detection.
Real-time
performed.
results
were
correlated
classical
Jaffe
calorimetric
method.
Our
exhibited
better
response.
Thus,
it
diagnostic
further
development
rapid
precise
platform
point-of-care
(POC)
devices
examining
patients
disease.
Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 22, 2024
Abstract
The
increasing
prevalence
of
health
concerns
has
sparked
a
demand
for
advanced
monitoring
tools,
which
is
significant
challenge
researchers.
Analysis
biofluid
samples
and
biomarker
vital
comprehensive
assessment.
In
this
context,
metal–organic
frameworks
(MOFs)
have
emerged
as
one
the
leading
materials
developing
cutting‐edge
artificial
sensors.
These
unique
MOFs
been
developed
from
metallic
organic
linkers
consist
tunable
pores
dynamic
surface
areas,
attracting
various
guest
molecules
to
participate
in
electrochemical
devices.
This
study
gateway
world
where
MOF
designs
transcend
mere
inventions,
morphing
into
electric
marvels
that
revolutionize
urine
sample
monitoring.
From
inception
design
fabrication
sensors
tailored
applications,
prides
itself
on
elucidating
factors
affecting
MOF‐based
electrical
devices
Moreover,
focus
placed
conductivity,
electrode
properties,
recent
state‐of‐the‐art
analysis,
highlighting
pivotal
role
biomarkers
play
honing
resilience
performance
Finally,
specific
used
analysis.
It
will
attract
researchers
develop
new
portable
tools
by
analyzing
samples.
ACS Biomaterials Science & Engineering,
Journal Year:
2024,
Volume and Issue:
10(10), P. 6603 - 6614
Published: Oct. 2, 2024
In
recent
years,
an
increase
in
the
number
of
chronic
kidney
disease
(CKD)
cases
has
led
to
a
global
health
burden
majorly
affecting
underdeveloped
and
developing
nations.
A
key
biomarker
for
assessing
kidneys'
normal
functioning
is
creatinine,
which
filtered
out
from
blood
by
kidney.
Thus,
timely
specific
detection
creatinine
becomes
necessary
diagnosis
subsequent
treatment
CKD.
Hence,
this
study,
we
have
tried
develop
field-deployable,
software-integrated
immunosensor
serum
sample.
The
was
developed
incorporating
gold
nanoparticles,
boron
doped
MXene,
polyaniline,
anticreatinine
antibody
using
appropriate
bioconjugation
reaction.
sensor
able
detect
linear
dynamic
range
10
nM
0.1
M
with
limit
1.72
(±0.07)
nM.
integrated
indigenously
software
named
"CretCheck"
simplifies
process
data
analysis.
personalized
biosensing
device
used
find
concentrations
directly
obtained
analytical
signals.
can
also
be
implemented
primary
care
facilities
future.
The Analyst,
Journal Year:
2024,
Volume and Issue:
149(10), P. 2905 - 2914
Published: Jan. 1, 2024
A
non-enzymatic
electrochemical
sensor
prepared
using
a
Cu
NP
film/NF
electrode
was
used
to
detect
creatinine
levels
in
human
urine.
The
is
highly
reproducible
and
cost-effective,
as
well
reliably
stable
for
long-term
storage.
