Recent advances in reactive oxygen species (ROS)-responsive drug delivery systems for photodynamic therapy of cancer

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(12), P. 5106 - 5131

Published: Nov. 2, 2024

Reactive oxygen species (ROS)-responsive drug delivery systems (DDSs) have garnered significant attention in cancer research because of their potential for precise spatiotemporal release tailored to high ROS levels within tumors. Despite the challenges posed by distribution heterogeneity and endogenous supply constraints, this review highlights strategic alliance ROS-responsive DDSs with photodynamic therapy (PDT), enabling selective leveraging PDT-induced enhanced therapeutic efficacy. This delves into biological importance progression treatment. We elucidate detail operational mechanisms linkers, including thioether, thioketal, selenide, diselencide, telluride aryl boronic acids/esters, as well latest developments nanomedicines that integrate PDT strategies. These insights are intended inspire design innovative nanocarriers PDT.

Language: Английский

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Effect of photopolymerization and color phase transition on the structural color expression of long-chain diynoate-modified titanium dioxide multiparticle layers

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2025, Volume and Issue: unknown, P. 136784 - 136784

Published: April 1, 2025

Language: Английский

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Strong red upconversion luminescence of Yb3+/Er3+ co-doped Sc6WO12 phosphor for optical thermometry

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1319, P. 139511 - 139511

Published: July 30, 2024

Language: Английский

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Wireless subcutaneous power supplies for recharging implanted electronic devices

Device, Journal Year: 2024, Volume and Issue: 2(10), P. 100423 - 100423

Published: Oct. 1, 2024

Language: Английский

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A BODIPY‐Ferrocene Conjugate for the Combined Photodynamic Therapy and Chemodynamic Therapy with Improved Antitumor Efficiency

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: unknown

Published: July 18, 2024

Abstract Photodynamic therapy (PDT) can destroy tumor cells by generating singlet oxygen ( 1 O 2 ) under light irradiation, which is limited the hypoxia of neoplastic tissue. Chemodynamic (CDT) produce toxic hydroxyl radical (⋅OH) to eradicate catalytic decomposition endogenous hydrogen peroxide (H ), therapeutic effect highly dependent on concentration H . Herein, we propose a BODIPY‐ferrocene conjugate with balanced and ⋅OH generation capacity, serve as high‐efficiency antitumor agent combining PDT CDT. The ferrocene moieties endow as‐prepared conjugates ability chemodynamic killing cells. Moreover, combined PDT/CDT improved efficiency be realized after exposure irradiation. Compared monotherapy or CDT, significantly increase intracellular ROS levels thereby inducing cell apoptosis at low drug doses. In this way, synergistic treatment achieved combination

Language: Английский

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Advances and perspectives in use of semisolid formulations for photodynamic methods

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2024, Volume and Issue: 204, P. 114485 - 114485

Published: Sept. 8, 2024

Language: Английский

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Highlighting Contributions from our Editorial Board Members in 2023

Langmuir, Journal Year: 2024, Volume and Issue: 40(32), P. 16665 - 16669

Published: Aug. 13, 2024

Language: Английский

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