Understanding the formulation parameters for engineering indocyanine green J-aggregate lipid nanocapsules and solid lipid nanoparticles as promising photothermal agents

European Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 207, P. 107034 - 107034

Published: Feb. 6, 2025

Indocyanine green J-aggregate (IJA) is a promising photothermal (PTT) agent that has recently been utilised in preclinical studies for cancer diagnostics and treatment. The unique properties, such as the red-shift absorption band longer wavelengths, are behind IJA's superior thermal stability compared to its monomeric ICG. Loading IJA into nanoparticles (NPs) proven advantageous enhancing vivo targeting of various models. However, loading more complex lipids, lipid nanocapsules (LNCs) solid (SLNs), not reported. present work focuses on investigations effect formulation parameters pre-formed (p-IJA) formation p-IJA-loaded LNCs SLNs, thus their theranostic applications. We investigated shell core SLN p-IJA stability. Our findings demonstrated significant role lipophilic surfactants (Span 85) high-melting-point (sodium stearate) ratio heating capacity following SLNs. More importantly, p-IJA-SLN enhanced optical range biological media, serum proteins, blood, collagen. Furthermore, lyophilised p-IJA-SLNs were successfully obtained after long-term storage. Overall, NPs could provide platform applications, including photoacoustic imaging, PTT, photodynamic therapy (PDT), combination with chemotherapeutics.

Language: Английский

Functionalized Nanomaterials in Cancer Treatment: A Review

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2633 - 2633

Published: March 14, 2025

Cancer is one of the main causes death worldwide. Chemotherapy, radiotherapy and surgery are currently treatments choice for cancer. However, conventional therapies have their limitations, such as non-specificity, tumor recurrence toxicity to target cells. Recently, nanomaterials been considered therapeutic agents against This mainly due unique optical properties, biocompatibility, large surface area nanoscale size. These properties crucial they can affect biocompatibility uptake by cell, reducing efficacy. because nanoparticles be functionalized with biomolecules, become more biocompatible, which improves uptake, specifically targeted cancer cells, anticancer activity. In this review, we summarize some recent studies in aim increasing efficacy treatment.

Language: Английский

Development of targeted lipid nanoparticles for the combined therapy of triple negative breast cancer: can curcumin and 6-aminoflavone promote doxorubicin in vitro efficacy?

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106414 - 106414

Published: Nov. 1, 2024

Language: Английский