Mitochondrial targeting and pH‐responsive release of dual‐functionalized mesoporous silica nanoparticles as pesticide carrier

Pest Management Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Abstract BACKGROUND Suitable nano‐pesticide carriers play a crucial role in enhancing the utilization efficiency of pesticides. Among these, mesoporous silica nanoparticles (MSNs) are most promising candidates for large‐scale and safe pesticide applications. RESULTS In present work, functionalized MSNs were demonstrated to be effective mitochondrial‐targeted delivering strobilurin fungicides (mitochondrial respiratory chain inhibitors). bi‐functionalized with carboxymethyl chitosan (CMC), which is pH‐responsive, (4‐carboxybutyl) triphenylphosphonium bromide (TPP), mitochondrial targeting. The loading capacity model pyraclostrobin (Py) on carrier reached 32%. vitro release experiments Py sustained performance carriers. Co‐localization mitochondria confirmed that targeting by nanoparticle carrier. Bioactivity assays showed superior antifungal activity Py@MSNs‐CMC‐TPP compared mono‐functionalized commercial suspension products. Moreover, even when concentrations Py@MSNs‐CMC increased 200% relative Py@MSNs‐CMC‐TPP, inhibition remained lower. This indicates reduced required amount while its efficiency. CONCLUSION With application pesticides, such as methoxyacrylates succinate dehydrogenase inhibitors, have significant potential emerge promising, environmentally friendly fungicide formulation. © 2025 Society Chemical Industry.

Language: Английский

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Anti-Mold Activities of Cationic Oligomeric Surfactants

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Molds are persistent and harmful but receive far less research attention compared with pathogenic bacteria. With the increase in microbial resistance to single-chain surfactant antimicrobial agents, it is crucial investigate how structures affect activity of surfactants. Here, we have studied antimold efficacy a series oligomeric cationic quaternary ammonium surfactants at varying oligomerization levels or without dynamic covalent imine bonds. Four common molds chosen as representatives: A. niger, T. viride, C. globosum, P. funiculosum. The minimum fungicidal concentration (MFC) results indicate that solution display stronger than same degree bonds, decreases increases. superior imine-based attributed their longer hydrophobic chains benzene rings, which enhance interactions mold membranes, causing perforation membrane disruption. Nonetheless, higher reduces effectiveness due formation overly stable aggregates, lower free molecular monomers released from aggregates may accumulate on spore membranes. However, fabric surfaces, show performance. multiple headgroups result greater adsorption antimildew activity. Moreover, reversibility plays significant role reducing likelihood resistance. This work helpful construct agents broad-spectrum weak potential.

Language: Английский

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Degradable mesoporous organosilicon nanoparticles coated with chitosan-Cu2+ complexes with dual stimulus-response for efficient prochloraz delivery

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 303, P. 140709 - 140709

Published: Feb. 6, 2025

Language: Английский

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Preparation, characterization, and morphology control of micron-sized monodisperse thiol-containing hollow organosilica microspheres

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2025, Volume and Issue: unknown, P. 137119 - 137119

Published: May 1, 2025

Language: Английский

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Mixing Intensification for Advanced Materials Manufacturing

Engineering, Journal Year: 2024, Volume and Issue: 44, P. 135 - 144

Published: Dec. 28, 2024

Language: Английский

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