Ultrasound-assisted preparation of shikonin-loaded emulsions for the treatment of bacterial infections

Ultrasonics Sonochemistry, Journal Year: 2025, Volume and Issue: 115, P. 107302 - 107302

Published: March 4, 2025

Bacteria can encapsulate themselves in a self-generated matrix of hydrated extracellular polymeric substances such as polysaccharides, proteins, and nucleic acids, thereby forming bacterial biofilm infections. These biofilms are drug resistant will diminish the efficacy antimicrobial agents, rendering treatment infections challenging. Herein, an innovative strategy is proposed to synergistically degrade eradicate entrapped bacteria through integrating α-amylase (α-Amy), shikonin (SK) epigallocatechin gallate (EGCG) within emulsion. The natural protein α-Amy deployed enzymatically hydrolyze polysaccharide biofilms. Due amphipilic properties cross-linking capability EGCG, formed α-Amy/SK@EGCG emulsion possess high stability. SK was encapsulated ultrasound-assisted assembly, targeting treat infection after degradation. In vitro vivo experiments demonstrate that polyphenol-protein stabilized loaded with antibacterial achieves profound penetration into due hydrolysis mediated by α-Amy. As result, significantly alleviate inflammation symptoms accelerate healing process biofilm-infected wounds. This study provides promising therapeutic for development novel materials aimed enhanced

Language: Английский

Self-healing hydrogel based on polyvinyl alcohol/dextran with hyperglycemia-triggered cascade enzyme catalytic activity promotes diabetic wound healing

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 693, P. 137615 - 137615

Published: April 16, 2025

Language: Английский