Biocompatible Lyotropic Nanocarriers for Improved Delivery of Ascorbyl Tetraisopalmitate in Skincare
Xintong Han,
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Qimin Yan,
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Ning Gao
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et al.
Langmuir,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 27, 2025
Ascorbyl
tetraisopalmitate
(VC-IP)
is
a
novel
form
of
ascorbic
acid
characterized
by
reduced
water
solubility
due
to
complete
acylation
with
palmitate.
This
study
investigated
the
potential
cosmetic
application
VC-IP
when
encapsulated
in
lyotropic
liquid
crystal
nanoparticles
(VC-IP
LCNPs)
using
high-pressure
homogenization
(HPH)
method.
The
particle
size,
zeta
potential,
and
polydispersity
index
(PDI)
obtained
LCNPs
were
determined
as
158.8
±
3.2
nm,
−35.1
2.8
mV,
0.12
0.02,
respectively.
drug
loading
(DL%)
was
approximately
35.1%.
Morphological
changes
LCNPs,
transitioning
from
sponge
phase
vesicles,
confirmed
successful
VC-IP,
demonstrated
transmission
electron
microscopy
(Cryo-TEM)
small-angle
X-ray
scattering
(SAXS)
experiments.
sustained
release
also
observed
through
Franz
transdermal
diffusion
test,
indicating
that
facilitated
sustained-release
effect
into
skin.
exhibited
good
biocompatibility,
showing
nontoxicity
HaCaT
cells
zebrafish
embryos.
Raman
distribution
imaging
successfully
penetrated
stratum
corneum
reached
dermis.
In
assessments
whitening
effects,
significantly
reactive
oxygen
species
(ROS)
content
melanin
areas
heads
zebrafish.
Furthermore,
effectively
inhibited
tyrosinase
activity
proliferation
A375
compared
pure
VC-IP.
Additionally,
area
Therefore,
developed
present
promising
carrier
for
enhanced
active
ingredients,
such
products.
Language: Английский
CuO-TiO2–Saponite Ternary Nanocomposite for Efficient Removal of Bromocresol Green Dye
Minerals,
Journal Year:
2024,
Volume and Issue:
14(12), P. 1268 - 1268
Published: Dec. 13, 2024
This
study
presents
the
synthesis
of
a
CuO-TiO2–saponite
ternary
nanocomposite
via
hydrothermal
method,
designed
to
efficiently
remove
bromocresol
green
dye.
Characterization
techniques,
including
X-ray
diffraction,
Fourier
transform
infrared
spectroscopy,
and
scanning
electron
microscopy,
confirmed
significant
interactions
between
metal
oxide
nanoparticles
clay
mineral
matrix.
Diffuse
reflectance
photoluminescence
analyses
revealed
narrow
band
gap
surface
defects,
such
as
oxygen
vacancies,
enhancing
material’s
photocatalytic
properties.
Under
UV
irradiation,
achieved
83%
discoloration
dye
within
150
min.
The
inhibitor
studies
identified
hydroxyl
superoxide
radicals
key
species
in
degradation
mechanism.
work
underscores
potential
clay-mineral-based
nanocomposites,
where
minerals
function
both
structural
support
enhancers
semiconductor’s
activity.
Language: Английский