Engineering dual-driven pro-angiogenic nanozyme based on porous silicon for synergistic acceleration of burn infected wound healing

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101522 - 101522

Published: Jan. 25, 2025

Language: Английский

---

The protective effect and experimental research progress of pleotropic statins in intervertebral disc degeneration

Journal of Orthopaedic Surgery and Research, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 31, 2025

Language: Английский

---

Advances in Neurological Pain Management: Bridging Scientific Innovations and Clinical Practice

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Neuronal pain, including neuropathic migraines, and chronic pain syndromes, presents a significant global health challenge. This literature review covers studies conducted until 2024 using major databases, PubMed Google Scholar, with the search terms "Neuropathic Pain/therapy" OR "Chronic "Pain Management/methods" "Neuromodulation/methods" "Spinal Cord Stimulation" "Deep Brain "Transcranial Magnetic Direct Current "Nav1.7 Voltage-Gated Sodium Channel" "Biologics/pharmacology" "Drug Delivery Systems/methods" "Regenerative Medicine/methods" "Stem Cell Transplantation/methods" "Platelet-Rich Plasma/therapeutic use" "Tissue Engineering/methods" "Biomarkers/metabolism" "Machine Learning" "Precision Medicine." explores contemporary advancements in neurological therapy, emphasizing analytical that translate into clinical applications. The research foundation is built on modern examining mechanisms, pharmaceutical innovations, neuromodulation strategies, personalized management, regenerative medicine. Notable include neuroinflammation research, molecular genetic factor discoveries, development of selective Nav1.7 inhibitors, biologics, advanced drug delivery systems. Neuromodulation techniques, both invasive (e.g., deep brain stimulation (DBS), spinal cord (SCS)) noninvasive transcranial direct current (tDCS), magnetic (TMS)), play crucial role modulation. Regenerative approaches, stem cell platelet-rich plasma (PRP), tissue engineering, offer promising solutions for repair symptom relief. Additionally, genomic data, biomarkers, machine learning enhance precision management. Ethical considerations regarding treatment accessibility opioid alternatives remain critical, particularly Hispanic Americans facing language barriers programs like Optum. Selective serotonin reuptake inhibitors (SSRIs) continue to be widely used mental treatment. In conclusion, convergence translational innovative therapies, medicine marks transformative era improving patient outcomes quality life.

Language: Английский

---

Itaconate-loaded metal–organic framework (MOF) nanomedicine for the sustained treatment of intervertebral disk degeneration

APL Materials, Journal Year: 2025, Volume and Issue: 13(4)

Published: April 1, 2025

Intervertebral disk degeneration (IVDD) is a major cause of spinal pathology and pain can lead to disability in adults severe cases. The medication against limited due the lack therapeutic drugs ineffective delivery molecular target microenvironment. Itaconate tricarboxylic acid cycle secondary metabolite with inflammatory oxidative stress modulating functions, which could alleviate degeneration. However, vivo stability limits potential application itaconate In this study, we prepared metal–organic framework (MOF) nanocarrier drug loaded that respond acidic environment during results showed microenvironment induce sustained release from MOF@itaconate. vitro cellular evaluation MOF@itaconate has good cytocompatibility significantly attenuates injury nucleus pulposus cells. activates nuclear factor erythroid 2-related 2 (Nrf 2) anti-oxidative pathway promotes expression extracellular matrix components. For treatment intervertebral on animal models, was further coated hyaluronic (HA) boost effect. administration MOF@itaconate@HA rat model effectively delayed degenerative process, suggesting technology may provide an effective controlled-release strategy for IVDD.

Language: Английский

---

Chitosan-Functionalized Nanobubbles for Precision Oncology: Advances in Targeted Cancer Therapeutics

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

The convergence of nanotechnology and cancer therapeutics has opened new frontiers in the development advanced drug delivery systems. Among various nanocarriers, nanobubbles offer significant potential due to their unique properties, such as high payload capacity, responsiveness external stimuli like ultrasound, enhanced permeability retention (EPR) effects. Functionalizing these with chitosan, a naturally derived biopolymer known for its biocompatibility, biodegradability, ability enhance cellular uptake, further improves therapeutic efficacy. This review provides comprehensive analysis synthesis, functionalization, application chitosan-functionalized therapy. We discuss mechanism action, including targeted delivery, ultrasound-mediated release, immune modulation, alongside recent advancements challenges clinical translation. also explores future directions this rapidly evolving field, aiming insights into next-generation therapeutics.

Language: Английский

---

Local drug delivery challenges and innovations in spinal neurosurgery

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 376, P. 1225 - 1250

Published: Nov. 12, 2024

Language: Английский

---

Nanoscale Lipid-Methylprednisolone Conjugates: Effective Anti-Inflammatory, Antioxidant, and Analgesic Agents

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 101, P. 106251 - 106251

Published: Oct. 2, 2024

Language: Английский

---