Mindfulness-based stress reduction training and supplemented Jinshui Liujun decoction promote recovery in patients with non-small cell lung cancer DOI
Dai‐Wei Liu, Xiangdong Zhou, Xiao‐Yuan Wu

et al.

World Journal of Psychiatry, Journal Year: 2024, Volume and Issue: 14(12), P. 1876 - 1885

Published: Nov. 27, 2024

BACKGROUND Conventional chemotherapy (CC) administered to patients with non-small cell lung cancer (NSCLC) often causes adverse effects, such as cardiopulmonary dysfunction and immune system imbalance. Patients may experience anxiety depression during the perioperative period due various factors, treatment costs recurrence risks, thereby compromising overall quality of life. Consequently, we hypothesized that integrating mindfulness-based stress reduction training (MSRT) Jinshui Liujun decoction mitigate negative emotions promote recovery in NSCLC. AIM To explore effects MSRT on function emotional state NSCLC patients. METHODS A retrospective clinical study was conducted involving 92 stage IIIb-IV NSCLC; 35 control group (CG) received CC therapy (combination pemetrexed carboplatin), 57 (TG) MSRT-assisted flavored (FJLD) addition CC. We evaluated survival time, Karnofsky performance status, efficacy, traditional Chinese medicine syndrome score, function, level, reactions CG TG. RESULTS Median progression-free survival, efficacy TG were superior those (P < 0.05). Symptoms cough, weakness, bloody sputum, shortness breath, chest pain significantly decreased compared In TG, + FJLD increased numbers CD3+ CD4+ cells, effectively reduced number CD8+ enhanced CD4+/CD8+ ratio, restoring self-rating scale scores significantly. There no statistically significant difference incidence between > CONCLUSION proved be an effective for

Language: Английский

Ferroptosis and noncoding RNAs: exploring mechanisms in lung cancer treatment DOI Creative Commons

Nadi Rostami Ravari,

Farzad Sadri,

Mohammad Ali Mahdiabadi

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 26, 2025

Lung cancer (LC) is a highly prevalent and deadly type of characterized by intricate molecular pathways that drive tumor development, metastasis, resistance to conventional treatments. Recently, ferroptosis, controlled mechanism cell death instigated iron-dependent lipid peroxidation, has gained attention for its role in LC progression treatment. Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) long noncoding (lncRNAs), are emerging key modulators significantly influencing biology. This review explores how ncRNAs control ferroptotic affect growth, therapy LC. By understanding the dual functions both activating inhibiting we aim uncover new therapeutic targets strategies These insights provide promising direction development ncRNA-based treatments designed induce potentially improving outcomes patients with

Language: Английский

Citations

0
Enhancing recovery in non-small cell lung cancer patients through mindfulness training and Jinshui Liujun decoction supplementation DOI
Haewon Byeon

World Journal of Psychiatry, Journal Year: 2025, Volume and Issue: 15(3)

Published: Feb. 26, 2025

This article delves into the research conducted by Liu DW et al on integration of mindfulness-based stress reduction training (MSRT) and flavored Jinshui Liujun decoction (FJLD) with conventional chemotherapy (CC) in treatment non-small cell lung cancer. The study investigates impact this combined approach immune function emotional well-being cancer patients. Patients were divided a control group (CG) receiving CC alone (TG) MSRT + FJLD alongside CC. primary outcomes progression-free survival overall survival, secondary including Karnofsky performance status scores, clinical efficacy, markers, state assessments. findings underscore significant improvements median (20.50 months TG vs 13.10 CG, P < 0.05), scores (60 50 ratios, along reductions negative emotions (self-rating anxiety scale self-rating depression significantly lower TG, 0.05) among patients conjunction highlights potential combining traditional Chinese medicine modern psychological interventions to enhance efficacy treatments improve patient outcomes.

Language: Английский

Citations

0
Lysosome-Targeting Chimera Using Mannose-6-Phosphate Glycans Derived from Glyco-Engineered Yeast DOI

Seobin Kim,

Jiyeon Kang,

D.R. An

et al.

Bioconjugate Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Lysosome-targeting chimeras (LYTACs) harness the cell's lysosomal degradation machinery to break down extracellular and membrane proteins. Previous methods used a synthetic glycopeptide containing multiple serine-O-mannose-6-phosphate (poly-M6Pn), which presented challenges such as complexity potential immunogenicity associated with poly-M6Pn. This study introduced LYTAC formulation, LYTACgyM6pG, uses glyco-engineered yeast-derived mannose-6-phosphate glycans (gyM6pGs) for transport, overcoming complexities immunogenic risks. The gyM6pGs in LYTACgyM6pG are human-compatible (identical structures found humans) efficiently produced through yeast fermentation, followed by preparation of cell wall their vitro modifications. We employed copper-free click chemistry (azide dibenzocyclooctyne reactions) robust conjugation nanobody targeting immune checkpoint protein PD-L1, thereby streamlining assembly LYTACgyM6pG. demonstrated that effectively degraded endogenous recombinant PD-L1 proteins on surface directing them lysosome via cation-independent receptor pathway. Furthermore, significantly enhanced T cell-mediated cytotoxicity against cancer cells, surpassing efficacy nanobodies alone. successful application development highlights more viable scalable therapeutic production LYTACs, paving way broader applications, including treatment.

Language: Английский

Citations

0
A Biotin-selective Molecular Imprinted Polymer Containing Fe3O4 Nanoparticles and CD44-selective Aptamer for Targeting Cancer Hyperthermia Therapy DOI
Feng‐Shuo Yang,

C. Hung,

Yu‐Lun Lo

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106972 - 106972

Published: April 1, 2025

Language: Английский

Citations

0
Unraveling the interplay of CD8 + T cells and microRNA signaling in cancer: implications for immune dysfunction and therapeutic approaches DOI Creative Commons

Arefeh Zabeti Touchaei,

Sogand Vahidi

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 20, 2024

Language: Английский

Citations

2
Mindfulness-based stress reduction training and supplemented Jinshui Liujun decoction promote recovery in patients with non-small cell lung cancer DOI
Dai‐Wei Liu, Xiangdong Zhou, Xiao‐Yuan Wu

et al.

World Journal of Psychiatry, Journal Year: 2024, Volume and Issue: 14(12), P. 1876 - 1885

Published: Nov. 27, 2024

BACKGROUND Conventional chemotherapy (CC) administered to patients with non-small cell lung cancer (NSCLC) often causes adverse effects, such as cardiopulmonary dysfunction and immune system imbalance. Patients may experience anxiety depression during the perioperative period due various factors, treatment costs recurrence risks, thereby compromising overall quality of life. Consequently, we hypothesized that integrating mindfulness-based stress reduction training (MSRT) Jinshui Liujun decoction mitigate negative emotions promote recovery in NSCLC. AIM To explore effects MSRT on function emotional state NSCLC patients. METHODS A retrospective clinical study was conducted involving 92 stage IIIb-IV NSCLC; 35 control group (CG) received CC therapy (combination pemetrexed carboplatin), 57 (TG) MSRT-assisted flavored (FJLD) addition CC. We evaluated survival time, Karnofsky performance status, efficacy, traditional Chinese medicine syndrome score, function, level, reactions CG TG. RESULTS Median progression-free survival, efficacy TG were superior those (P < 0.05). Symptoms cough, weakness, bloody sputum, shortness breath, chest pain significantly decreased compared In TG, + FJLD increased numbers CD3+ CD4+ cells, effectively reduced number CD8+ enhanced CD4+/CD8+ ratio, restoring self-rating scale scores significantly. There no statistically significant difference incidence between > CONCLUSION proved be an effective for

Language: Английский

Citations

1