Bibliometric analysis of photodynamic research in bladder cancer: trends and future directions

Photodiagnosis and Photodynamic Therapy, Journal Year: 2025, Volume and Issue: 52, P. 104494 - 104494

Published: Jan. 22, 2025

Recent years have seen the use of photodynamic technologies concerning detection and therapy bladder cancer (BC) due to their rapid development well-established therapeutic impact. However, a thorough analysis bibliometric assessment publishing trends in BC has not been completed yet. Retrieving bibliographies from Web Science Core Collection limited publication date December 31, 2023, January 1, 2004. We used VOSviewer (Version 1.6.19) CiteSpace 6.4 R1) for both statistical visualization analysis. selected total 870 documents The yearly findings show notable upward patterns over last two decades. Kochi Medical School Japan was most productive school, while USA nation. Japanese researcher Inoue Keiji published highest number -related articles BC. quoted prolific journals were Photodynamic Therapy Photodiagnosis. According keyword analysis, terms "cystoscopy," "carcinoma situ," "drug delivery," "follow-up," "hexaminolevulinate," "impact" are all relatively recent hot field. Our investigation produced outcome field, potentially opening up new research opportunities. suggest that future concentrate on in-situ carcinoma identification, photosensitizer invention, medication delivery enhancement, technology follow-up

Language: Английский

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Biomimetic Self-Oxygenated Immunoliposome for Cancer-Targeted Photodynamic Immunotherapy

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2743 - 2759

Published: March 1, 2025

Photodynamic therapy (PDT) is a promising strategy with significant clinical application potential for tumor treatment. However, the hypoxia and limited efficacy against metastasis present limitations in of PDT. To alleviate PDT growth metastasis, we developed self-oxygenated immunoliposome by encapsulating catalase (CAT) within liposome cavity loading photosensitizer chlorin e6 (Ce6) immunoadjuvant MPLA lipid bilayer (CAT@LP-Ce6-A). Subsequently, fused it cancer cell membrane (CCM) to create hybrid (CAT@LP-CCM-Ce6-A). The vitro vivo anti-cancer CAT@LP-CCM-Ce6-A-based photodynamic immunotherapy (PDIT) was evaluated. CAT@LP-CCM-Ce6-A were characterized size, zeta potential, transmission electron microscopy (TEM), Coomassie bright blue staining, UV spectrophotometer, standard Goth's method. Cellular uptake, viability, reactive oxygen species (1O2) generation, calreticulin exposure, ability promote BMDCs maturation evaluated vitro. Biodistribution, therapeutic efficacy, safety investigated orthotopic triple-negative breast (TNBC) lung mouse models. successfully via thin film hydration co-extrusion capacity Ce6 CAT 4.7 ± 0.9% 8.5 respectively. exhibited improved cellular uptake efficiency cytotoxicity under laser irradiation TNBC. Furthermore, possessed enhanced anti-enzymatic degradation promotion DC maturation. In TNBC-bearing mice, PDIT demonstrated remarkable effect antitumor immunity while maintaining minimal systemic toxicity. could be employed as an innovative approach cancer.

Language: Английский

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A Novel Approach for Bladder Cancer Treatment: Nanoparticles as a Drug Delivery System

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 13461 - 13483

Published: Dec. 1, 2024

Bladder cancer represents one of the most prevalent malignant neoplasms urinary tract. In Asian context, it eighth common in males. 2022, there were approximately 613,791 individuals diagnosed with bladder worldwide. Despite availability efficacious treatments for two principal forms cancer, namely non-invasive and invasive high incidence recurrence following treatment suboptimal outcomes observed patients high-grade advanced disease represent significant concerns management at this juncture. Nanoparticles have gained attention their excellent properties, including stable physical a porous structure that can be loaded variety substances, so on. The in-depth research on nanoparticles has led to emergence as new class combination therapy, due advantageous properties. These include extension drug release window, enhancement bioavailability, improvement targeting ability, reduction local systemic toxicity, simultaneous delivery multiple drugs therapy. As result, become novel agent system. advent provided impetus development non-surgical chemotherapy, immunotherapy, gene therapy phototherapy. unique properties facilitated diverse therapeutic modalities, enhancing overall efficacy. This review examines recent advancements use treatments, encompassing aspects such delivery, efficacy, associated toxicity nanoparticles, well challenges encountered clinical applications.

Language: Английский

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Preparation of photo-controlled release ROS-responsive Ce6/elemene co-loaded liposomes and study on the effect on enhancing apoptosis of NMIBC

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117398 - 117398

Published: Sept. 8, 2024

Language: Английский

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