A State‐of‐the‐Art Appraisal of Nanomaterials in Microneedles in the Delivery of Therapeutics and Vaccines DOI Creative Commons
Bwalya A. Witika, Aaron R.J. Hutton, Pedzisai A. Makoni

et al.

Advanced NanoBiomed Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

Nanomaterial‐loaded microneedles are a novel development in the fields of medicine and vaccines. Researchers have created extremely effective systems for targeted controlled delivery variety bioactive agents by fusing nanomaterials with microneedle platforms. The design manufacturing processes nanomaterial‐loaded covered herein, along applications to improve drug stability, bioavailability, patient adherence. Important preclinical clinical studies that demonstrate efficiency these delivering small molecules, biologics, vaccines also review. In order direct ongoing research expedite translation this promising technology, important challenges future directions identified. This review offers thorough evaluation most recent developments quickly developing field technology.

Language: Английский

Pathophysiology and Treatment of Psoriasis: From Clinical Practice to Basic Research DOI Creative Commons
Yujie Gao, Tianqi Xu, Yu Wang

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 56 - 56

Published: Jan. 3, 2025

Psoriasis, a chronic inflammatory dermatosis, represents significant clinical challenge due to its complex pathogenesis and the limitations of existing therapeutic strategies. Current psoriasis diagnoses are primarily clinician-dependent, with instrumental diagnostics serving as adjuncts. Ongoing research is progressively deciphering molecular underpinnings; future may involve genetic immunological profiling pinpoint biomarkers, enabling more accurate timely interventions. The administration medications, whether oral, injectable, or topical, associated range side effects compliance issues. Topical despite their advantages in patient reduced systemic effects, hindered by altered skin barrier psoriasis, which impedes effective drug penetration retention. In recent years, development novel transdermal delivery systems promising frontier management. Nanotechnology-, microneedle- dressing-based have demonstrated potential for improved penetration, enhanced bioavailability, extended retention time. Here, we will focus on latest insights into etiology, diagnostic methodologies, approaches particular emphasis evolution challenges systems.

Language: Английский

Citations

1
Nanoformulation-assisted microneedle transdermal drug delivery system: An innovative platform enhancing rheumatoid arthritis treatment DOI Open Access

Yao Wendong,

Yan Xingxing,

Xie Xianze

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117219 - 117219

Published: July 30, 2024

A transdermal delivery system offers high bioavailability and favorable patient adherence, constituting an optimal approach for localized administration in rheumatoid arthritis (RA) treatment. However, the stratum corneum (SC) impedes efficiency of conventional drug systems. Microneedles (MNs) can temporarily create micropores within SC, enabling distribution via bypassing this barrier enhancing effectiveness. Notably, MNs provide a painless method through skin may directly modulate inflammation immune cells by delivering drugs lymphatic during administration. MN is not suitable with low water solubility stability. Additionally, major concerns exist regarding safety using highly cytotoxic drugs, given that it could result local concentration at site. While exhibit some degree targeted to inflammatory environment, their targeting remains suboptimal. Nanoformulations have potential significantly address limitations RA treatment improving targeting, solubility, stability, biocompatibility. Therefore, review provides concise overview advantages, disadvantages, mechanisms different types It specifically focuses on application advantages combining nanoformulation summarizes current trends development nanoformulations combined field treatment, offering theoretical support future advancements clinical applications.

Language: Английский

Citations

5
Novel Small-Molecule Treatment and Emerging Biological Therapy for Psoriasis DOI Creative Commons
Yuanyuan Li,

Yiheng Cheng,

Yuchen Cai

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 781 - 781

Published: March 23, 2025

Psoriasis is an immune-related disorder that marked by abnormal thickening of the skin, rapid multiplication keratinocytes, and complex interactions between immune cells affected areas. Although psoriasis cannot currently be cured, drugs can alleviate symptoms regulating homeostasis preventing comorbidities. There are many types to treat psoriasis: small-molecule drugs, including corticosteroids; retinoids; vitamin D analogs; immunosuppressants, such as glucocorticoid ointment, tretinoin cream, methotrexate tablets, etc. Macromolecular biological Certolizumab, Secukinumab, Guselkumab, etc., include monoclonal antibodies target various inflammatory signaling pathways. Compared with traditional therapies offer better targeting lower systemic side effects, but their high costs invasive administration modes constrict widespread use. Spesolimab latest agent used interleukin-36 receptor (IL-36R) approved for market use, which significantly reduces risk general pustular (GPP) flare 84%. Additionally, there several agents interleukin-23/T helper 17 cell pathway have already entered Phase II III clinical trials. At present, first-line therapeutic strategy mild topical administration. Systemic therapy phototherapy preferred treating moderate severe types. However, current completely meet needs. More advanced drug delivery systems optimized effects bioavailability required. Nanocarriers emerging proteins, nucleic acids, cell-based therapies. In this review, we analyze status therapeutics discuss novel diverse well We also summarize effectiveness different strategies.

Language: Английский

Citations

0
3D-printed acyclovir nanocrystals: An advanced approach to herpes simplex treatment DOI Creative Commons
Lucía López-Vidal,

Kornelija Juskaite,

Octavio E. Fandiño

et al.

Applied Materials Today, Journal Year: 2025, Volume and Issue: 44, P. 102695 - 102695

Published: April 8, 2025

Language: Английский

Citations

0
Deferasirox nanosuspension loaded dissolving microneedles for ocular drug delivery DOI Creative Commons

Hafsa Shahid Faizi,

Muhammad Iqbal Nasiri, Yu‐Wei Wu

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 664, P. 124614 - 124614

Published: Aug. 22, 2024

Deferasirox (DFS) is an oral iron chelator that employed in retinal ailments as a neuroprotectant against injury and thus has utility treating disorders such excitoneurotoxicity age-related macular degeneration (AMD). However, the conventional route of administration can present several disadvantages, e.g., need for more frequent dosing first-pass effect. Microneedles (MNs) are minimally invasive systems be intrascleral drug delivery without pain advantageously replace intravitreal injections therapy (IVT) well routes DFS. In this study, DFS was formulated into nanosuspension (NS) through wet media milling employing PVA stabilizer, which successfully loaded polymeric dissolving MNs. exhibited 4-fold increase solubility DFS-NS compared to pure Moreover, DFS-NSs excellent short-term stability enhanced thermal stability, confirmed thermogravimetric analysis (TGA) studies. The mechanical characterization ocular microneedles (DFS-NS-OcMNs), revealed system sufficiently strong effective scleral penetration. Optical coherence tomography (OCT) images insertion 81.23 ± 7.35 % total height MN arrays full-thickness porcine sclera. Scleral deposition studies 64 after just 5 min from DFS-NS-loaded (OcMNs), almost times greater than DFS-OcMNs. Furthermore, both DFS-NS-OcMN remarkable cell viability when evaluated on human pigment (ARPE) cells, suggesting their safety appropriateness use eye. Therefore, loading novel devices promising technique effectively delivering posterior segment eye manner.

Language: Английский

Citations

3
Microneedles as an Emerging Platform for Transdermal Delivery of Phytochemicals DOI Creative Commons
B.H. Jaswanth Gowda, Mohammed Gulzar Ahmed,

Raghu Raj Singh Thakur

et al.

Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

Phytochemicals, which are predominantly found in plants, hold substantial medicinal value. Despite their potential, challenges such as poor oral bioavailability and instability the gastrointestinal tract have limited therapeutic use. Traditional intra/transdermal drug delivery systems offer some advantages over administration but still suffer from issues penetration depth, slow release rates, inconsistent absorption. In contrast, microneedles (MNs) represent a significant advancement by providing precise control phytochemical enhanced capabilities. By circumventing skin barriers, MNs directly access dermal layers rich blood vessels lymphatics, thus facilitating efficient delivery. This review extensively discusses obstacles of traditional benefits routes with particular focus on transformative potential for explores complexities delivering phytochemicals through routes, development types innovative tools, optimal design properties effective Additionally, this examines versatile applications MN-mediated delivery, including its role administering phytophotosensitizers photodynamic therapy, concludes insights into relevant patents future perspectives.

Language: Английский

Citations

2
An initial investigation of transcutaneous delivery of plasmid DNA encoding interleukin-10 for the treatment of psoriatic skin conditions DOI
Igor Rafael Correia Rocha,

Maggie R. Finch,

Jayson B. Ball

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 123, P. 903 - 913

Published: Nov. 1, 2024

Language: Английский

Citations

0
A State‐of‐the‐Art Appraisal of Nanomaterials in Microneedles in the Delivery of Therapeutics and Vaccines DOI Creative Commons
Bwalya A. Witika, Aaron R.J. Hutton, Pedzisai A. Makoni

et al.

Advanced NanoBiomed Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

Nanomaterial‐loaded microneedles are a novel development in the fields of medicine and vaccines. Researchers have created extremely effective systems for targeted controlled delivery variety bioactive agents by fusing nanomaterials with microneedle platforms. The design manufacturing processes nanomaterial‐loaded covered herein, along applications to improve drug stability, bioavailability, patient adherence. Important preclinical clinical studies that demonstrate efficiency these delivering small molecules, biologics, vaccines also review. In order direct ongoing research expedite translation this promising technology, important challenges future directions identified. This review offers thorough evaluation most recent developments quickly developing field technology.

Language: Английский

Citations

0