Trivalent Disulfide Unit-Masked System Efficiently Delivers Large Oligonucleotide DOI Creative Commons
Lei Wang, Xiao Liu,

Yiliang Wu

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(17), P. 4223 - 4223

Published: Sept. 5, 2024

Oligonucleotide drugs are shining in clinical therapeutics, but efficient and safe delivery systems severely limit their widespread use. A disulfide unit technology platform based on dynamic thiol exchange chemistry at the cell membrane has potential for drug delivery. However, alteration of CSSC dihedral angle induced by different substituents directly affects effectiveness this its stability. Previously, we constructed a trivalent low that can effectively promote cellular uptake small molecules. Here, novel unit-masked oligonucleotide hybrid unit, motivated prodrug design. Cellular imaging results showed such system exhibited superior efficiency than commercial Lipo2000 without cytotoxicity. The reagents significantly reduced (57–74%), which proved to be endocytosis-independent. In addition, vivo distribution experiments mice rapidly distributed liver tissues with duration action more 24 h, representing means silencing genes involved pathogenesis liver-like diseases. conclusion, deliver large drugs.

Language: Английский

Innovative composite systems for enhancing plant polyphenol stability and bioavailability DOI Creative Commons
Fengguang Pan, Xianglin Liu,

Mengying Qiao

et al.

Food Science and Biotechnology, Journal Year: 2025, Volume and Issue: 34(9), P. 1819 - 1834

Published: Jan. 6, 2025

Language: Английский

Citations

1
Ferulic Acid: A Comprehensive Review DOI Open Access

J. Purushothaman,

Md. Rizwanullah

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 28, 2024

Ferulic acid (FA), a phenolic compound abundant in the cell walls of seeds, leaves, and roots various fruits, vegetables, cereals, grains, is renowned for its wide range biological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer properties. Despite therapeutic potential, clinical application FA hindered by challenges such as poor water solubility, limited bioavailability, rapid metabolism, instability under physiological conditions. To address these issues, nanotechnology has emerged transformative approach, enhancing FA's pharmacokinetic profile. Various nanoparticle-based systems, polymer-based lipid-based nanoparticles, have been developed to encapsulate FA. These systems demonstrated significant improvements stability, with studies showing enhanced antioxidant activity controlled release profiles. Further, surface engineering nanoparticles provides targeted drug/phytochemical delivery potential. The drugs/phytochemicals significantly enhances efficacy minimizes systemic side effects. This review explores potential FA, limitations application, advancements that are paving way effective use.

Language: Английский

Citations

4
State-of-the-art surfactants as biomedical game changers: unlocking their potential in drug delivery, diagnostics, and tissue engineering DOI

Karuppiah Nagaraj,

Subramaniam Kamalesu

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125590 - 125590

Published: April 1, 2025

Language: Английский

Citations

0
Unveiling the role of nanoparticle-based therapeutic strategies for pulmonary drug delivery DOI

Prashant Anilkumar Singh,

Ramendra Pati Pandey, Rajendra Awasthi

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106558 - 106558

Published: Dec. 1, 2024

Language: Английский

Citations

3
Sustained Delivery of Liraglutide Using Multivesicular Liposome Based on Mixed Phospholipids DOI Creative Commons

Runpeng Zhang,

Xinyu Yao, Siqi Gao

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 203 - 203

Published: Feb. 6, 2025

Background: Although peptides are widely used in the clinical treatment of various diseases due to their strong biological activity, they usually require frequent injections owing poor vivo half-life. Therefore, there is a need for sustained peptide formulations. Methods: In this study, liraglutide (Lir) and biocompatible multivesicular liposomes (MVLs) were utilized as model drug sustained-release carriers, respectively. The release rate Lir-MVLs was controlled by changing ratio SPC DEPC with different phase transition temperatures (PTT, PTTSPC = −20 °C, PTTDEPC 13 °C). Results: As increased, had more flexible lipid membranes, poorer structural stabilization, fewer internal vesicles larger particle sizes, contributing faster Lir. After subcutaneous injection Lir-MVLs, blood glucose concentration (BGC) db/db mice decreased levels. When SPC-DEPC greater than 85:15, too fast; BGC remained below 16 mM only 2–4 days, while when slow, case less 50:50, also 2–3 days. However, 75:25, could be maintained 8 indicating that properties best met pharmacological requirements Conclusions: This study investigated effects phospholipids PTT on characteristics provided ideas design preparations.

Language: Английский

Citations

0
Advanced Drug Delivery Systems for Topical Insulin in Diabetic Wound Healing DOI

Sheida Barkhordari,

Farangis Shahi,

Hossein Ali Khonakdar

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(44)

Published: Nov. 1, 2024

Abstract Diabetes mellitus is a chronic condition characterized by impaired insulin production or utilization, leading to serious complications such as diabetic foot ulcers (DFUs). DFUs are wounds with high levels of inflammatory cytokines, arterial occlusion, and persistent infection, often resulting in significant morbidity. Traditional treatment methods, including debridement, offloading, infection control, have shown limited success, prompting the exploration novel therapeutic strategies. Insulin, known for its role glucose metabolism, also possesses wound‐healing properties promoting cell proliferation, protein synthesis, modulating inflammation. However, systemic administration not ideal due hypoglycemia risks difficulties achieving concentrations at wound sites. This review focuses on advanced drug delivery systems topical application dressings. Various platforms, hydrogels, nanoparticles, liposomes, microemulsions been developed optimize bioavailability, protect it from degradation, ensure controlled release. These aim enhance management addressing multifactorial nature healing patients. The provides comprehensive overview current advancements, evaluates efficacy these preclinical clinical studies, discusses challenges future perspectives this field. By highlighting potential innovative approaches, underscores promise improving patient outcomes.

Language: Английский

Citations

2
Recent progress and current status of surface engineered magnetic nanostructures in cancer theranostics DOI

Bijaideep Dutta,

K.C. Barick, P. A. Hassan

et al.

Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 334, P. 103320 - 103320

Published: Oct. 30, 2024

Language: Английский

Citations

0
Trivalent Disulfide Unit-Masked System Efficiently Delivers Large Oligonucleotide DOI Creative Commons
Lei Wang, Xiao Liu,

Yiliang Wu

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(17), P. 4223 - 4223

Published: Sept. 5, 2024

Oligonucleotide drugs are shining in clinical therapeutics, but efficient and safe delivery systems severely limit their widespread use. A disulfide unit technology platform based on dynamic thiol exchange chemistry at the cell membrane has potential for drug delivery. However, alteration of CSSC dihedral angle induced by different substituents directly affects effectiveness this its stability. Previously, we constructed a trivalent low that can effectively promote cellular uptake small molecules. Here, novel unit-masked oligonucleotide hybrid unit, motivated prodrug design. Cellular imaging results showed such system exhibited superior efficiency than commercial Lipo2000 without cytotoxicity. The reagents significantly reduced (57–74%), which proved to be endocytosis-independent. In addition, vivo distribution experiments mice rapidly distributed liver tissues with duration action more 24 h, representing means silencing genes involved pathogenesis liver-like diseases. conclusion, deliver large drugs.

Language: Английский

Citations

0