Structural landscape of new salts of the antihistamine drug bilastine: implications in physicochemical properties and anticancer activity against skin cancer

CrystEngComm, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Seven new salts of the antihistamine drug bilastine were prepared with inorganic acid counter ions and demonstrated modified solubility & dissolution along study anti-cancer activity against skin cancer.

Language: Английский

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Drug functional remapping: a new promise for tumor immunotherapy

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: March 14, 2025

The research and development of new anti-cancer drugs face challenges such as high costs, lengthy cycles, limited data on side effects. In contrast, the clinical safety effects traditional have been well established through long-term use. or repurposing with potential applications in cancer treatment offers an economical, feasible, promising strategy for drug development. This article reviews novel tumor immunotherapy, discussing how they can enhance efficacy functional repositioning, while also reducing time costs. Recent advancements immunotherapy revolutionized options, but resistance to ICIs remains a significant challenge. Drug has emerged identify agents that immunotherapies by overcoming ICI resistance. A study suggests repositioning modulate immune cell activity alter microenvironment, thereby circumventing mechanisms associated checkpoint blockade. approach provides rapid cost-effective pathway identifying therapeutic candidates be quickly transitioned into trials. To improve effectiveness it is crucial explore systematic methods repurposed candidates. Methods high-throughput screening, computational bioinformatic analysis employed efficiently treatment. Furthermore, leveraging databases related provide valuable resources discovery facilitate identification compounds. It focuses latest use antidiabetic drugs, antihypertensive agents, weight-loss medications, antifungal antiviral examining their action, application prospects, challenges. this context, our aim these strategies highlight expanding options available providing references

Language: Английский

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Drug‐Drug Cocrystals

Published: March 29, 2025

Language: Английский

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Valorization of deoiled herb of Mentha arvensis via phytochemical investigation and anticancer activity against breast cancer

Industrial Crops and Products, Journal Year: 2024, Volume and Issue: 224, P. 120319 - 120319

Published: Dec. 13, 2024

Language: Английский

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