Synthesis of Amphiphilic Amino Poly-Amido-Saccharide and Poly(lactic) Acid Block Copolymers and Fabrication of Paclitaxel-Loaded Mucoadhesive Nanoparticles DOI
Robert C. Sabatelle,

Abraham D. Geller,

Siyuan Li

et al.

Bioconjugate Chemistry, Journal Year: 2024, Volume and Issue: 35(9), P. 1429 - 1440

Published: Aug. 19, 2024

Drug delivery to the esophagus through systemic administration remains challenging, as minimal drug reaches desired target. Local offers potential for improved efficacy while minimizing off-target toxicities but necessitates bioadhesive properties mucosal delivery. Herein, we describe synthesis of two new mucoadhesive amphiphilic copolymers prepared by sequential ring-opening copolymerization or postpolymerization click conjugation. Both strategies yield block containing a hydrophilic amine-functionalized poly-amido-saccharide and either hydrophobic alkyl derivatized poly(lactic acid), respectively. The latter resulting readily self-assemble into spherical, ≈200 nm diameter, positively charged nanoparticles. NPs entrap ultrahigh levels paclitaxel via encapsulation free conjugated biodegradable, biocompatible poly(1,2-glycerol carbonate). Paclitaxel-loaded rapidly enter cells, release paclitaxel, are cytotoxic esophageal OE33 OE19 tumor cells in vitro, and, importantly, demonstrate mucoadhesion compared conventional poly(ethylene glycol)-poly(lactic acid) nanoparticles ex vivo tissue.

Language: Английский

High antigen-presenting CAF levels correlate with reduced glycosaminoglycan biosynthesis-heparan sulfate/heparin metabolism in immune cells and poor prognosis in esophageal squamous cell carcinoma: Insights from bulk and single-cell transcriptome profiling DOI
Siliang Wang,

Van Kelly,

Mei Zhen

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140418 - 140418

Published: Jan. 1, 2025

Language: Английский

Citations

0
Paeonol enhances a recombinant EGFR-targeted fusion protein-drug conjugate induced antitumor efficacy in esophageal cancer DOI
Huaiyu Duan, Yuting Li, Xue Zheng

et al.

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: 236, P. 116856 - 116856

Published: March 5, 2025

Language: Английский

Citations

0
Unlocking the Therapeutic Potential of Natural Polyphenols in Esophageal Cancer DOI
Chengu Niu, Jing Zhang, Patrick Okolo

et al.

Current Treatment Options in Oncology, Journal Year: 2025, Volume and Issue: unknown

Published: March 22, 2025

Language: Английский

Citations

0
Synthesis of Amphiphilic Amino Poly-Amido-Saccharide and Poly(lactic) Acid Block Copolymers and Fabrication of Paclitaxel-Loaded Mucoadhesive Nanoparticles DOI
Robert C. Sabatelle,

Abraham D. Geller,

Siyuan Li

et al.

Bioconjugate Chemistry, Journal Year: 2024, Volume and Issue: 35(9), P. 1429 - 1440

Published: Aug. 19, 2024

Drug delivery to the esophagus through systemic administration remains challenging, as minimal drug reaches desired target. Local offers potential for improved efficacy while minimizing off-target toxicities but necessitates bioadhesive properties mucosal delivery. Herein, we describe synthesis of two new mucoadhesive amphiphilic copolymers prepared by sequential ring-opening copolymerization or postpolymerization click conjugation. Both strategies yield block containing a hydrophilic amine-functionalized poly-amido-saccharide and either hydrophobic alkyl derivatized poly(lactic acid), respectively. The latter resulting readily self-assemble into spherical, ≈200 nm diameter, positively charged nanoparticles. NPs entrap ultrahigh levels paclitaxel via encapsulation free conjugated biodegradable, biocompatible poly(1,2-glycerol carbonate). Paclitaxel-loaded rapidly enter cells, release paclitaxel, are cytotoxic esophageal OE33 OE19 tumor cells in vitro, and, importantly, demonstrate mucoadhesion compared conventional poly(ethylene glycol)-poly(lactic acid) nanoparticles ex vivo tissue.

Language: Английский

Citations

0