Cited by Guiding excipient selection for physically stable Amorphous Solid Dispersions: A combined in-vitro in-silico approach

Extraction of Chlorogenic Acid Using Single and Mixed Solvents DOI

Hyeon Ji Jeon,

Bong‐Seop Lee, Changhyup Park

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 481 - 481

Published: Jan. 22, 2025

Chlorogenic acid, which is extracted from a wide range of natural sources, attracting the attention many researchers in pharmaceutical and biomedical fields due to its various positive effects, such as anti-inflammatory antibacterial properties. Considering effects economics solvent toxicity, water, ethanol, their mixtures were selected solvents for extracting chlorogenic acid at temperatures (298~318 K) over whole concentrations. The solubility increased with temperature regardless solvents, was higher pure ethanol than water. mixed exhibited gradual rise water content increased, reaching maximum specific weight fraction. These trends well predicted by COSMO-SAC model Hansen parameter method. By comparing σ-profile, it confirmed that comes similarity σ-profiles between represents surface charge density molecule.

Language: Английский

Citations

Rational design of PLA-based ASDs for pharmaceutical 3D printing: Insights from phase diagram modeling DOI

Alma Lucia Villela Zumaya, Anton Iemtsev, Michal Fulem

et al.

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2025, Volume and Issue: 208, P. 114657 - 114657

Published: Feb. 5, 2025

Language: Английский

Citations

Prediction of drug solubility in polymer with COSMO-SAC DOI

Xiaoci Lin, Heqing Huang, Chieh‐Ming Hsieh

et al.

Journal of the Taiwan Institute of Chemical Engineers, Journal Year: 2025, Volume and Issue: 173, P. 106177 - 106177

Published: May 16, 2025

Language: Английский

Citations

Combining high throughput ASD screening with the rDCS to streamline development of poorly soluble drugs DOI

Malte Bøgh Senniksen,

Nicole Wyttenbach,

Susanne Page

et al.

European Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 107130 - 107130

Published: May 1, 2025

Poor aqueous solubility and slow dissolution rate of active pharmaceutical ingredients (APIs) are often encountered challenges during oral drug development, leading to variable insufficient bioavailability. To overcome these challenges, a so-called "enabling" formulation strategy is pursued. Among these, amorphous solid dispersions (ASDs) established as an effective means improving absorption. However, evaluating the outcome in vitro ASD screening approaches relating this expected bioavailability increase can be difficult if not done systematically. Here we show, for first time, how combination high throughput method with refined Developability Classification System (rDCS) streamline poorly soluble APIs ASDs. Using Screening Polymers Amorphous Drug Stabilization (SPADS) approach rapidly prepare films, improvement performance three (befetupitant, celecoxib itraconazole) was investigated eight polymeric carriers. The results showed that concentration dissolved API highly dependent on both carrier load. For studied, Eudragit E, HPMC 100LV Soluplus especially advantageous effects Translating into rDCS framework allowed visualization left-shift (more favorable absorption) classification. Several films were classified class I, showing major from initial IIb classification pure API. This novel could expanded include diverse set methods enabling strategies, where allow direct comparison support selection.

Language: Английский

Citations

Guiding excipient selection for physically stable Amorphous Solid Dispersions: A combined in-vitro in-silico approach DOI

Egis Zeneli,

Hugo Bohets,

Frédéric Ngono Mebenga

et al.

European Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 107152 - 107152

Published: June 1, 2025

Language: Английский

Citations