Recent Advances in Cyclodextrin‐Based Nanoscale Drug Delivery Systems DOI
Fuat Topuz, Tamer Uyar

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(6)

Published: Oct. 31, 2024

ABSTRACT Cyclodextrins (CDs) belong to a class of cyclic oligosaccharides characterized by their toroidal shape consisting glucose units linked via α‐1,4‐glycosidic bonds. This distinctive exhibits dual nature, comprising hydrophobic interior and hydrophilic exterior, making CDs highly versatile in various pharmaceutical products. They serve multiple roles: they act as solubilizers, stabilizers, controlled release promoters, enhancers drug bioavailability, effective means masking undesirable tastes odors. Taking advantage these inherent benefits, have been integrated into numerous nanoscale delivery systems. The resulting nanomaterials exploit the exceptional properties CDs, including ability solubilize drugs for substantial loading, engage supramolecular complexation engineered nanomaterials, increase bioavailability improved therapeutic efficacy, stabilize labile drugs, exhibit biocompatibility versatility. paper compiles recent studies on CD functional platforms. First, we described physicochemical toxicological aspects CD/drug inclusion complexation, impact improving bioavailability. We then summarized applications CD‐functional nano systems based polymeric, hybrid, lipid‐based nanoparticles, CD‐based nanofibers. Particular interest was targeted function molecules used. In most applications, were used solubilization while some studies, employed construct Finally, review concludes with thoughtful consideration current challenges outlook.

Language: Английский

Supramolecular Luminescent Sensors DOI
Teresa L. Mako, Joan M. Racicot, Mindy Levine

et al.

Chemical Reviews, Journal Year: 2018, Volume and Issue: 119(1), P. 322 - 477

Published: Dec. 3, 2018

There is great need for stand-alone luminescence-based chemosensors that exemplify selectivity, sensitivity, and applicability overcome the challenges arise from complex, real-world media. Discussed herein are recent developments toward these goals in field of supramolecular luminescent chemosensors, including macrocycles, polymers, nanomaterials. Specific focus placed on development new macrocycle hosts since 2010, coupled with considerations underlying principles chemistry as well analytes interest common luminophores. State-of-the-art fields polymer nanomaterial sensors also examined, some remaining unsolved area discussed.

Language: Английский

Citations

621
Functional Supramolecular Polymeric Networks: The Marriage of Covalent Polymers and Macrocycle-Based Host–Guest Interactions DOI
Danyu Xia, Pi Wang, Xiaofan Ji

et al.

Chemical Reviews, Journal Year: 2020, Volume and Issue: 120(13), P. 6070 - 6123

Published: May 19, 2020

Covalent polymers connected by non-covalent interactions constitute a fascinating set of materials known as supramolecular polymer networks (SPNs). A key feature SPNs is that the underlying covalent endow resulting self-assembled with features, such structural and mechanical integrity, good processability, recyclability, stimuli-responsiveness, self-healing, shape memory, are not recapitulated in case classic systems. The unique nature derives from controlled marriage traditional macrocycle-based host-guest interactions. As consequence, polymeric have played important roles number diverse fields, including science, chemistry, biomedical materials, information storage technology. In this Review, we summarize advances made area functional SPNs, focus on original literature reports appearing past five years. treatment organized according to used produce various SPNs. role backbones also discussed.

Language: Английский

Citations

602
Cyclodextrin‐Based Multistimuli‐Responsive Supramolecular Assemblies and Their Biological Functions DOI

Ying‐Ming Zhang,

Yaohua Liu,

Yu Liu

et al.

Advanced Materials, Journal Year: 2019, Volume and Issue: 32(3)

Published: Feb. 18, 2019

Cyclodextrins (CDs), which are a class of cyclic oligosaccharides extracted from the enzymatic degradation starch, often utilized in molecular recognition and assembly constructs, primarily via host-guest interactions water. In this review, recent progress CD-based supramolecular nanoassemblies that sensitive to chemical, biological, physical stimuli is updated reviewed, intriguing examples biological functions these presented, including pH- redox-responsive drug gene delivery, enzyme-activated specific cargo release, photoswitchable morphological interconversion, microtubular aggregation, cell-cell communication, as well geomagnetism-controlled nanosystem for suppression tumor invasion metastasis. Moreover, future perspectives challenges fabrication intelligent biofunctional materials also discussed at end expected promote translational development nanomaterials biomedical field.

Language: Английский

Citations

355
Nanoencapsulation of carotenoids within lipid-based nanocarriers DOI
Hadis Rostamabadi, Seid Reza Falsafi, Seid Mahdi Jafari

et al.

Journal of Controlled Release, Journal Year: 2019, Volume and Issue: 298, P. 38 - 67

Published: Feb. 10, 2019

Language: Английский

Citations

250
Host-Guest Chemistry in Supramolecular Theranostics DOI Creative Commons
Guocan Yu, Xiaohong Chen

Theranostics, Journal Year: 2019, Volume and Issue: 9(11), P. 3041 - 3074

Published: Jan. 1, 2019

Macrocyclic hosts, such as cyclodextrins, calixarenes, cucurbiturils, and pillararenes, exhibit unparalleled advantages in disease diagnosis therapy over the past years by fully taking advantage of their host-guest molecular recognitions. The dynamic nature non-covalent interactions selective complexation endow resultant nanomaterials with intriguing properties, holding promising potentials theranostic fields. Interestingly, differences microenvironment between abnormal normal cells/tissues can be employed stimuli to modulate interactions, realizing purpose precise specific delivery drugs lesion sites. In this review, we summarize progress supramolecular theranostics on basis chemistry benefiting from fantastic topological structures outstanding chemistry. These state-of-the-art examples provide new methodologies overcome obstacles faced traditional systems, promoting clinical translations.

Language: Английский

Citations

191
Smart stimuli-responsive drug delivery systems based on cyclodextrin: A review DOI
Bingren Tian, Yumei Liu, Jiayue Liu

et al.

Carbohydrate Polymers, Journal Year: 2020, Volume and Issue: 251, P. 116871 - 116871

Published: Aug. 10, 2020

Language: Английский

Citations

190
Cyclodextrin-based delivery systems for chemotherapeutic anticancer drugs: A review DOI
Bingren Tian,

Shiyao Hua,

Jiayue Liu

et al.

Carbohydrate Polymers, Journal Year: 2019, Volume and Issue: 232, P. 115805 - 115805

Published: Dec. 30, 2019

Language: Английский

Citations

188
Multidimensional response of dopamine nano-system for on-demand fungicides delivery: Reduced toxicity and synergistic antibacterial effects DOI

Shuhao Lu,

Bin Liang,

Jianglong Hu

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 482, P. 148990 - 148990

Published: Jan. 23, 2024

Language: Английский

Citations

21
Cyclodextrins in Drug Delivery Systems and Their Effects on Biological Barriers DOI Creative Commons
Ádám Haimhoffer, Ágnes Rusznyák, Katalin Réti-Nagy

et al.

Scientia Pharmaceutica, Journal Year: 2019, Volume and Issue: 87(4), P. 33 - 33

Published: Nov. 20, 2019

Cyclodextrins are widely used excipients, composed of glucopyranose units with a cyclic structure. One their most important properties, is that inner cavity hydrophobic, while surface hydrophilic. This enables them for the complex formation lipophilic molecules. They have several applications in pharmaceutical field like solubility enhancers or building blocks larger drug delivery systems. On other hand, they numerous effects on cells biological barriers. In this review properties cyclodextrins and cyclodextrin-based systems summarized special focus activity.

Language: Английский

Citations

144
Cancer, Photodynamic Therapy and Porphyrin-Type Derivatives DOI Creative Commons
Ana T. P. C. Gomes,

M.G.P.M.S. Neves,

José A. S. Cavaleiro

et al.

Anais da Academia Brasileira de Ciências, Journal Year: 2018, Volume and Issue: 90(1 suppl 2), P. 993 - 1026

Published: Jan. 1, 2018

This review has two parts. The first one gives an approach to interdisciplinary studies against cancer carried out by many scientists using porphyrin-type substrates as photosensitizers in PDT. Intensive were performed for almost six decades. successes really started 1993 with the formulation patented under trade name Photofrin, which was immediately approved several countries treat certain types of cancer. Photofrin is still used although negative features soon became well known. That motivated search better new photosensitizers. Several ones developed, evaluated and a few them had clinical approval. group includes porphyrin derivatives pro-drugs (aminolevulinic acid its alkyl esters). Oncological, dermatological ophthalmic applications are now taking place benefit mankind. second part this related work Aveiro at authors University on synthesis biological evaluation potential PDT Not only synthetic methodologies mainly porphyrins chlorins developed but also other macrocycles phthalocyanine corrole have entered same "pipeline". In vivo vitro evaluations took studies.

Language: Английский

Citations

128