Frontiers in Bioengineering and Biotechnology,
Journal Year:
2023,
Volume and Issue:
11
Published: Feb. 22, 2023
Hydrogels
are
widely
used
biomaterials
in
the
delivery
of
therapeutic
agents,
including
drugs,
genes,
proteins,
etc.,
as
well
tissue
engineering,
due
to
obvious
properties
such
biocompatibility
and
their
similarity
natural
body
tissues.
Some
these
substances
have
feature
injectability,
which
means
that
substance
is
injected
into
desired
place
solution
state
then
turns
gel,
makes
it
possible
administer
them
from
a
way
with
minimal
amount
invasion
eliminate
need
for
surgery
implant
pre-formed
materials.
Gelation
can
be
caused
by
stimulus
and/or
spontaneously.
Suppose
this
induces
effect
one
or
many
stimuli.
In
case,
material
question
called
stimuli-responsive
because
responds
surrounding
conditions.
context,
we
introduce
different
stimuli
cause
gelation
investigate
mechanisms
transformation
gel
them.
Also,
study
special
structures,
nano
gels
nanocomposite
gels.
Cancer Medicine,
Journal Year:
2023,
Volume and Issue:
12(10), P. 11073 - 11096
Published: Jan. 16, 2023
Abstract
Colorectal
cancer
(CRC)
is
a
common
gastrointestinal
malignancy
with
high
morbidity
and
fatality.
Chemotherapy,
as
traditional
therapy
for
CRC,
has
exerted
well
antitumor
effect
greatly
improved
the
survival
of
CRC
patients.
Nevertheless,
chemoresistance
one
major
problems
during
chemotherapy
significantly
limits
efficacy
treatment
influences
prognosis
To
overcome
in
many
strategies
are
being
investigated.
Here,
we
review
novel
measures
to
combat
resistance,
including
drug
repurposing
(nonsteroidal
anti‐inflammatory
drugs,
metformin,
dichloroacetate,
enalapril,
ivermectin,
bazedoxifene,
melatonin,
S‐adenosylmethionine),
gene
(ribozymes,
RNAi,
CRISPR/Cas9,
epigenetic
therapy,
antisense
oligonucleotides,
noncoding
RNAs),
protein
inhibitor
(EFGR
inhibitor,
S1PR2
DNA
methyltransferase
inhibitor),
natural
herbal
compounds
(polyphenols,
terpenoids,
quinones,
alkaloids,
sterols),
new
delivery
system
(nanocarriers,
liposomes,
exosomes,
hydrogels),
combination
therapy.
These
or
reversal
promise
improve
CRC.
International Journal of Biological Macromolecules,
Journal Year:
2023,
Volume and Issue:
232, P. 123283 - 123283
Published: Jan. 17, 2023
Hydrogels
have
emerged
as
a
versatile
platform
for
numerous
biomedical
application
due
to
their
ability
absorb
huge
quantity
of
biofluids.
In
order
design
hydrogels,
natural
polymers
are
an
attractive
option
owing
biocompatibility
and
biodegradability.
Due
abundance
in
occurrence,
cost
effectiveness,
facile
crosslinking
approaches,
alginate
has
been
extensively
investigated
fabricate
hydrogel
matrix.
Management
cancer
chronic
wounds
always
challenge
pharmaceutical
healthcare
sector.
both
cases,
curcumin
shown
significant
improvement
effectiveness.
However,
the
innate
restraints
like
poor
bioavailability,
hydrophobicity,
rapid
systemic
clearance
associated
with
restricted
its
clinical
translations.
The
current
review
explores
cascade
research
around
encapsulated
matrix
wound
healing
therapy.
focus
is
emphasize
mechanistic
effects
fate
inside
cells.
Further,
discusses
different
approaches
designed
loaded
hydrogels
along
parameters
that
regulates
release
behavior.
Finally,
concluded
on
some
key
aspect
increasing
efficacy
these
novel
strategies
further
develop
multifacet
applications.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2023,
Volume and Issue:
11
Published: Feb. 22, 2023
Hydrogels
are
widely
used
biomaterials
in
the
delivery
of
therapeutic
agents,
including
drugs,
genes,
proteins,
etc.,
as
well
tissue
engineering,
due
to
obvious
properties
such
biocompatibility
and
their
similarity
natural
body
tissues.
Some
these
substances
have
feature
injectability,
which
means
that
substance
is
injected
into
desired
place
solution
state
then
turns
gel,
makes
it
possible
administer
them
from
a
way
with
minimal
amount
invasion
eliminate
need
for
surgery
implant
pre-formed
materials.
Gelation
can
be
caused
by
stimulus
and/or
spontaneously.
Suppose
this
induces
effect
one
or
many
stimuli.
In
case,
material
question
called
stimuli-responsive
because
responds
surrounding
conditions.
context,
we
introduce
different
stimuli
cause
gelation
investigate
mechanisms
transformation
gel
them.
Also,
study
special
structures,
nano
gels
nanocomposite
gels.
