ACS Biomaterials Science & Engineering,
Journal Year:
2024,
Volume and Issue:
10(8), P. 5290 - 5299
Published: July 16, 2024
Disturbing
cellular
redox
homeostasis
within
malignant
cells,
particularly
improving
reactive
oxygen
species
(ROS),
is
one
of
the
effective
strategies
for
cancer
therapy.
The
ROS
generation
based
on
nanozymes
presents
a
promising
strategy
treatment.
However,
therapeutic
efficacy
limited
due
to
insufficient
catalytic
activity
or
their
high
dependence
hydrogen
peroxide
(H2O2)
oxygen.
Herein,
we
reported
nanozyme
(CSA)
well-defined
CuSe
hollow
nanocubes
(CS)
uniformly
covered
with
Ag
nanoparticles
(AgNPs)
disturb
and
catalyze
cascade
intracellular
biochemical
reactions
produce
synergistic
therapy
breast
cancer.
In
this
system,
CSA
could
interact
thioredoxin
reductase
(TrxR)
deplete
tumor
microenvironment-activated
glutathione
(GSH),
disrupting
antioxidant
defense
system
augmenting
generation.
Besides,
possessed
peroxidase-mimicking
toward
H2O2,
leading
various
including
hydroxyl
radical
(•OH),
superoxide
radicals
(•O2-),
singlet
(1O2),
facilitated
by
Cu(II)/Cu(I)
H2O2
cycling,
plentiful
catalytically
active
metal
sites.
Additionally,
absorption
charge
separation
performance
AgNPs,
exhibited
excellent
photothermal
in
second
near-infrared
(NIR-II,
1064
nm)
region
enhanced
photocatalytic
level
cells.
Owing
inhibition
TrxR
activity,
GSH
depletion,
CSA,
abundant
generation,
displays
remarkable
specific
growth.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 6, 2024
Abstract
Tumor
progress
and
tumor‐associated
osteolysis
are
two
key
issues
of
breast
cancer
bone
metastasis,
which
makes
it
challenging
for
metastasis
treatment.
To
settle
these
concurrently,
a
versatile
semiconducting
nanointegrator
(termed
as
SPN
CpG/Ca
)
containing
polymer
nanoparticle
(SPN),
Ca
2+
cytosine‐phosphate‐guanine
(CpG)
oligonucleotides
conjugated
on
the
surface
via
singlet
oxygen
(
1
O
2
)‐responsive
linker,
is
designed.
The
antitumor
effect
can
be
triggered
with
X‐ray
irradiation
an
adjuvant,
in
works
radiosensitizer
to
produce
radiotherapy
controlled
release
CpG
disrupting
‐responsive
linkers.
accumulation
delivering
causes
tumor
cell
death
released
activates
immune
response
realize
immunotherapy.
combinational
action
radiotherapy,
overloading,
immunotherapy
results
complete
clearance
metastatic
cells
4T1
cancer‐based
mouse
models.
Furthermore,
accelerate
osteogenesis
marrow
mesenchymal
stem
while
inhibits
osteoclast
differentiation
microenvironment
alleviate
osteolysis,
synergistically
contributes
repair
destruction.
represents
therapeutic
nanosystem
abilities
treat
destruction,
providing
new
tactic
therapy.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(10), P. 2393 - 2393
Published: Sept. 27, 2023
This
study
aims
to
present
an
ultrasound-mediated
nanobubble
(NB)-based
gene
delivery
system
that
could
potentially
be
applied
in
the
future
treat
bone
disorders
such
as
osteoporosis.
NBs
are
sensitive
ultrasound
(US)
and
serve
a
controlled-released
carrier
deliver
mixture
of
Cathepsin
K
(CTSK)
siRNA
cerium
oxide
nanoparticles
(CeNPs).
platform
aimed
reduce
resorption
via
downregulating
CTSK
expression
osteoclasts
enhance
formation
antioxidant
osteogenic
properties
CeNPs.
CeNPs
were
synthesized
characterized
using
transmission
electron
microscopy
X-ray
photoelectron
spectroscopy.
The
was
adsorbed
surface
sonication
method.
release
profiles
labeled
with
fluorescent
tag
molecule
measured
after
low-intensity
pulsed
(LIPUS)
stimulation
maximum
for
1
mg/mL
NB-(CTSK
+
CeNPs)
obtained
at
2.5
nM
µg/mL,
respectively,
3
days
LIPUS
stimulation.
Then,
Alizarin
Red
Staining
(ARS)
human
marrow-derived
mesenchymal
stem
cells
(hMSC)
tartrate-resistant
acid
phosphatase
(TRAP)
staining
osteoclast
precursors
(OCP)
evaluate
promotion
osteoclastogenic
inhibition
effects.
A
higher
mineralization
lower
number
quantified
versus
control
+RANKL
ARS
(p
<
0.001)
TRAP-positive
0.01).
provides
method
silencing
US-sensitive
NB
used
vivo
treatment
fractures
ACS Biomaterials Science & Engineering,
Journal Year:
2024,
Volume and Issue:
10(8), P. 5290 - 5299
Published: July 16, 2024
Disturbing
cellular
redox
homeostasis
within
malignant
cells,
particularly
improving
reactive
oxygen
species
(ROS),
is
one
of
the
effective
strategies
for
cancer
therapy.
The
ROS
generation
based
on
nanozymes
presents
a
promising
strategy
treatment.
However,
therapeutic
efficacy
limited
due
to
insufficient
catalytic
activity
or
their
high
dependence
hydrogen
peroxide
(H2O2)
oxygen.
Herein,
we
reported
nanozyme
(CSA)
well-defined
CuSe
hollow
nanocubes
(CS)
uniformly
covered
with
Ag
nanoparticles
(AgNPs)
disturb
and
catalyze
cascade
intracellular
biochemical
reactions
produce
synergistic
therapy
breast
cancer.
In
this
system,
CSA
could
interact
thioredoxin
reductase
(TrxR)
deplete
tumor
microenvironment-activated
glutathione
(GSH),
disrupting
antioxidant
defense
system
augmenting
generation.
Besides,
possessed
peroxidase-mimicking
toward
H2O2,
leading
various
including
hydroxyl
radical
(•OH),
superoxide
radicals
(•O2-),
singlet
(1O2),
facilitated
by
Cu(II)/Cu(I)
H2O2
cycling,
plentiful
catalytically
active
metal
sites.
Additionally,
absorption
charge
separation
performance
AgNPs,
exhibited
excellent
photothermal
in
second
near-infrared
(NIR-II,
1064
nm)
region
enhanced
photocatalytic
level
cells.
Owing
inhibition
TrxR
activity,
GSH
depletion,
CSA,
abundant
generation,
displays
remarkable
specific
growth.
