Fabrication of Antibacterial Bone Scaffold Based on Carbonate-Substituted Hydroxyapatite Containing Magnesium from Black Sea Urchin (Arbacia Lixula) Shells Reinforced with Polyvinyl Alcohol and Gelatin DOI
Muhammad Amir Jamilludin,

Juliasih Partini,

Dwi Liliek Kusindarta

et al.

Published: Jan. 1, 2024

Carbonate-substituted hydroxyapatite containing magnesium (Mg-C-HAp) was introduced through dissolution precipitation treatment of (Mg-HAp) based on a black sea urchin (arbacia lixula) shells as novel biogenic materials. Based chemical composition analysis, the Mg-C-HAp form A- and B-type CHAp that contains high carbonate ions. The Ca/P ratio 1.707, very close to biological bone apatite 1.71. Mg content in also relatively high, distinguished Mg/(Ca+Mg) 0.139, which is potential an antibacterial agent. morphology showed particles with nanosize provide large surface area ion promotion. test revealed performed activity against Pseudomonas aeruginosa. Mg-C-HAp-based porous scaffolds were then fabricated using freeze-drying method variations polyvinyl alcohol (PVA) gelatin fraction. According physicochemical addition PVA scaffold structure decreased crystallinity Mg-C-HAp/PVA/Gel scaffold. This lower indicated biodegradability good for new growth. From SEM results, macropores appropriate blood vessel formation. micropores can be medium cells grow. microporosity suitable cell nutrient demonstrated P. aeruginosa, so maintain role purposes. properties represented its characteristics scaffolds.

Language: Английский

Fabrication of Antibacterial Bone Scaffold Based on Carbonate-Substituted Hydroxyapatite Containing Magnesium from Black Sea Urchin (Arbacia lixula) Shells Reinforced with Polyvinyl Alcohol and Gelatin DOI Creative Commons
Muhammad Amir Jamilludin,

Juliasih Partini,

Dwi Liliek Kusindarta

et al.

Results in Materials, Journal Year: 2024, Volume and Issue: 22, P. 100580 - 100580

Published: May 15, 2024

Carbonate-substituted hydroxyapatite containing magnesium (Mg-C-HAp) was introduced through dissolution-precipitation treatment of (Mg-HAp) based on a black sea urchin (arbacia lixula) shells as novel biogenic materials. Based chemical composition analysis, the Mg-C-HAp formed A- and B-type CHAp, which contained high carbonate ions. The Ca/P ratio 1.707, very close to biological bone apatite 1.71. Mg content in also relatively high, with Mg/(Ca+Mg) 0.139, is beneficial for antibacterial agents. morphology showed particles nanosize that provide large surface area ion promotion. test revealed performed activity against Pseudomonas aeruginosa. Mg-C-HAp-based porous scaffolds were then fabricated using freeze-drying method variations polyvinyl alcohol (PVA) gelatin fraction. According physicochemical addition PVA scaffold structure decreased crystallinity Mg-C-HAp/PVA/Gel scaffold. This lower indicated biodegradability, good new growth. macropores appropriate blood vessel formation. micropores can be medium cells grow. microporosity suitable cell nutrient compressive strength sufficient regeneration. demonstrated P. aeruginosa, so maintain role purposes. physicochemical, mechanical, properties represented its characteristics scaffolds.

Language: Английский

Citations

3
Gelation Dynamics, Formation Mechanism, Functionalization, and 3D Bioprinting of Silk Fibroin Hydrogel Materials for Biomedical Applications DOI

Linpeng Fan,

Zengxiao Cai, Jian Zhao

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: May 9, 2025

Silk fibroin (SF), derived from silk cocoon fibers (Bombyx mori), is a natural protein polymer known for its biocompatibility, biodegradability, and sustainability. The can be processed into various material formats suitable range of applications. Among these, SF hydrogels are useful in the biomedical field, such as tissue engineering, due to tailorable structures properties achievable through tuning gelation process. Therefore, focus this contribution comprehensively review understand formation, mechanism, dynamic control, functionalization hydrogels. Unlike previous reviews, work delves understanding strategies mechanisms dynamics molecular assembly crystallization points view. Further, presents pathways practical examples, 3D printing hydrogels, illustrate how these strategies, mechanisms, implemented specific application scenario. With insights, researchers gain deeper manipulate or control process types achieve features. This knowledge would further facilitate development hydrogel materials fields.

Language: Английский

Citations

0
Functionalized cellulose nanofibrils in carbonate-substituted hydroxyapatite nanorod-based scaffold from long-spined sea urchin (Diadema setosum) shells reinforced with polyvinyl alcohol for alveolar bone tissue engineering DOI Creative Commons
Muhammad Amir Jamilludin, I Kadek Hariscandra Dinatha, Apri I. Supii

et al.

RSC Advances, Journal Year: 2023, Volume and Issue: 13(46), P. 32444 - 32456

Published: Jan. 1, 2023

In this study, carbonate-substituted hydroxyapatite (C-HAp) nanorods were synthesised using a dissolution-precipitation reaction on (HAp) based long-spined sea urchin (

Language: Английский

Citations

7
Noninvasive Transdermal Administration of mRNA Vaccines Encoding Multivalent Neoantigens Effectively Inhibits Melanoma Growth DOI

Yuting Hou,

Zhe Wang, Zhen Chen

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(7), P. 4587 - 4600

Published: June 13, 2024

It is difficult to obtain specific tumor antigens, which one of the main obstacles in development vaccines. The vaccines containing multivalent antigens are thought be more effective antitumor therapy. In this study, a mRNA encoding three neoantigens melanoma were prepared and encapsulated into mannosylated chitosan-modified ethosomes (EthsMC) vaccine (MmRV) for transcutaneous immunization (TCI). MmRV can effectively induce maturation dendritic cells, with better performance than single neoantigen. TCI patches (TCIPs) loading or siRNA against PDL1 (siPDL1) applied skin melanoma-bearing mice. results showed that TCIPs significantly increase levels TNF-α, IFN-γ, IL-12 both plasma tissues, inhibit growth, as well promote infiltration CD4+ CD8+ T cells tissues. Furthermore, combination siPDL1 much effects either monotherapy, suggesting synergistic effect between blocker. addition, treatment did not cause damage skin, blood, vital organs mice, showing good biosafety. To best our knowledge, work first construct noninvasive system siPDL1, providing convenient promising approach treatment.

Language: Английский

Citations

2
Electrospinning based biomaterials for biomimetic fabrication, bioactive protein delivery and wound regenerative repair DOI Creative Commons
Xinyi Dai, Wei Nie,

Hua Shen

et al.

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 3, 2024

Abstract Electrospinning is a remarkably straightforward and adaptable technique that can be employed to process an array of synthetic natural materials, resulting in the production nanoscale fibers. It has emerged as novel for biomedical applications gained increasing popularity research community recent times. In context tissue repair engineering, there growing tendency toward integration biomimetic scaffolds bioactive macromolecules, particularly proteins growth factors. The design ‘smart’ systems provides not merely physical support, but also microenvironmental cues guide regenerative repair. Electrospun nanofibrous matrices are regarded highly promising tool this area, they serve both extracellular matrix (ECM)-mimicking scaffold vehicle delivery proteins. Their porous architecture high surface-to-volume ratio facilitate loading drugs mass transfer. By employing judicious selection materials processing techniques, considerable flexibility efficiently customizing nanofiber incorporating This article presents review strategies structural modification protein electrospun with focus on objective achieving tailored response. goes discuss challenges currently facing field suggest future directions.

Language: Английский

Citations

1
Biobased Polybutyrolactam Nanofiber with Excellent Biodegradability and Cell Growth for Sustainable Healthcare Textiles DOI
Jian Zhao, Run Zhang, Yajing Zhang

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(9), P. 5745 - 5757

Published: Aug. 22, 2024

The white pollution caused by unsustainable materials is a significant challenge around the globe. Here, novel and fully biobased polybutyrolactam (PBY) nanofiber membrane was fabricated via electrospinning method. As-spun PBY membranes have good thermal stability, high porosity of up to 71.94%, excellent wetting behavior. biodegradability in soil, UV aging irradiation, seawater investigated. almost completely degraded soil within 80 days, showing degradability. More interestingly, γ-aminobutyric acid, as healthcare agent with intrinsic hypotensive, tranquilizing, diuretic, antidiabetic efficacy, can be detected degradation intermediates. In addition, also exhibits antibacterial ability against

Language: Английский

Citations

1
Fabrication of Antibacterial Bone Scaffold Based on Carbonate-Substituted Hydroxyapatite Containing Magnesium from Black Sea Urchin (Arbacia Lixula) Shells Reinforced with Polyvinyl Alcohol and Gelatin DOI
Muhammad Amir Jamilludin,

Juliasih Partini,

Dwi Liliek Kusindarta

et al.

Published: Jan. 1, 2024

Carbonate-substituted hydroxyapatite containing magnesium (Mg-C-HAp) was introduced through dissolution precipitation treatment of (Mg-HAp) based on a black sea urchin (arbacia lixula) shells as novel biogenic materials. Based chemical composition analysis, the Mg-C-HAp form A- and B-type CHAp that contains high carbonate ions. The Ca/P ratio 1.707, very close to biological bone apatite 1.71. Mg content in also relatively high, distinguished Mg/(Ca+Mg) 0.139, which is potential an antibacterial agent. morphology showed particles with nanosize provide large surface area ion promotion. test revealed performed activity against Pseudomonas aeruginosa. Mg-C-HAp-based porous scaffolds were then fabricated using freeze-drying method variations polyvinyl alcohol (PVA) gelatin fraction. According physicochemical addition PVA scaffold structure decreased crystallinity Mg-C-HAp/PVA/Gel scaffold. This lower indicated biodegradability good for new growth. From SEM results, macropores appropriate blood vessel formation. micropores can be medium cells grow. microporosity suitable cell nutrient demonstrated P. aeruginosa, so maintain role purposes. properties represented its characteristics scaffolds.

Language: Английский

Citations

0