Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(10), P. 2302 - 2302
Published: Oct. 10, 2024
The
bloodstream
and
the
central
nervous
system
(CNS)
are
separated
by
blood–brain
barrier
(BBB),
an
intricate
network
of
blood
vessels.
Its
main
role
is
to
regulate
environment
within
brain.
primary
obstacle
for
drugs
enter
CNS
low
permeability
BBB,
presenting
a
significant
hurdle
in
treating
brain
disorders.
In
recent
years,
advancements
have
been
made
researching
methods
breach
BBB.
However,
understanding
how
penetrate
BBB
essential
drug
delivery
techniques.
Therefore,
this
article
reviews
mechanisms
breaking
through
as
well
current
research
progress
on
mechanism.
ChemMedChem,
Journal Year:
2024,
Volume and Issue:
19(16)
Published: May 9, 2024
Lipid
nanoparticles
(LNPs)
are
the
most
clinically
successful
drug
delivery
systems
that
have
accelerated
development
of
mRNA
drugs
and
vaccines.
Among
various
structural
components
LNPs,
more
recent
attention
has
been
paid
in
ionizable
lipids
(ILs)
was
supposed
as
key
component
determining
effectiveness
LNPs
for
vivo
delivery.
ILs
typically
comprised
three
moieties
including
heads,
linkers,
hydrophobic
tails,
which
suggested
combination
different
functional
groups
could
produce
with
diverse
chemical
structures
biological
identities.
In
this
concept
article,
we
provide
a
summary
design
strategy
high-performing
IL
candidates
discuss
their
structure-activity
relationships
shifting
tissue-selective
We
also
propose
an
outlook
next-generation
ILs,
enabling
broader
translation
formulated
LNPs.
Drug Delivery and Translational Research,
Journal Year:
2024,
Volume and Issue:
14(10), P. 2823 - 2844
Published: June 3, 2024
Abstract
Breast
cancer
(BC)
prevails
as
a
major
burden
on
global
healthcare,
being
the
most
prevalent
form
of
among
women.
BC
is
complex
and
heterogeneous
disease,
current
therapies,
such
chemotherapy
radiotherapy,
frequently
fall
short
in
providing
effective
solutions.
These
treatments
fail
to
mitigate
risk
recurrence
cause
severe
side
effects
that,
turn,
compromise
therapeutic
responses
patients.
Over
last
decade,
several
strategies
have
been
proposed
overcome
these
limitations.
Among
them,
RNA-based
technologies
demonstrated
their
potential
across
various
clinical
applications,
notably
therapy.
However,
RNA
therapies
are
still
limited
by
series
critical
issues
like
off-target
effect
poor
stability
circulation.
Thus,
novel
approaches
investigated
improve
targeting
bioavailability
formulations
achieve
an
appropriate
outcome.
Lipid
nanoparticles
(LNPs)
largely
proven
be
advantageous
carrier
for
nucleic
acids
RNA.
This
perspective
explores
recent
advances
technology
with
emphasis
LNPs’
utilization
nanocarriers
therapy
progresses
applications.
Graphical
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(6), P. 763 - 763
Published: June 11, 2024
Prime
editing
shows
potential
as
a
precision
genome
technology,
well
the
to
advance
development
of
next-generation
nanomedicine
for
addressing
neurological
disorders.
However,
turning
in
prime
editors
(PEs),
which
are
macromolecular
complexes
composed
CRISPR/Cas9
nickase
fused
with
reverse
transcriptase
and
guide
RNA
(pegRNA),
brain
remains
considerable
challenge
due
physiological
obstacles,
including
blood–brain
barrier
(BBB).
This
review
article
offers
an
up-to-date
overview
perspective
on
latest
technologies
strategies
delivery
PEs
passage
through
blood
barriers.
Furthermore,
it
delves
into
scientific
significance
possible
therapeutic
applications
conditions
related
diseases.
It
is
targeted
at
clinicians
clinical
researchers
working
advancing
neuropathologies.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(10), P. 2302 - 2302
Published: Oct. 10, 2024
The
bloodstream
and
the
central
nervous
system
(CNS)
are
separated
by
blood–brain
barrier
(BBB),
an
intricate
network
of
blood
vessels.
Its
main
role
is
to
regulate
environment
within
brain.
primary
obstacle
for
drugs
enter
CNS
low
permeability
BBB,
presenting
a
significant
hurdle
in
treating
brain
disorders.
In
recent
years,
advancements
have
been
made
researching
methods
breach
BBB.
However,
understanding
how
penetrate
BBB
essential
drug
delivery
techniques.
Therefore,
this
article
reviews
mechanisms
breaking
through
as
well
current
research
progress
on
mechanism.
