Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 351, P. 122967 - 122967
Published: Nov. 13, 2024
Language: Английский
Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 237, P. 113869 - 113869
Published: March 21, 2024
Language: Английский
Citations
11
ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(4), P. 2175 - 2185
Published: March 13, 2024
Lung cancer and Mycobacterium avium complex infection are lung diseases associated with high incidence mortality rates. Most conventional anticancer drugs antibiotics have certain limitations, including drug resistance rates adverse effects. Herein, we aimed to synthesize mannose surface-modified solid lipid nanoparticles (SLNs) loaded curcumin (Man-CUR SLN) for the effective treatment of disease. The synthesized Man-CUR SLNs were analyzed using various instrumental techniques structural physicochemical characterization. Loading into improved encapsulation efficiency release capacity, as demonstrated by high-performance liquid chromatography analysis. Furthermore, characterized effect A549 cell line. Cells treated SLN exhibited an increased cellular uptake cytotoxicity. Moreover, free CUR could more effectively reduce migration than SLNs. Similarly, elicited a stronger apoptosis-inducing that SLNs, reverse transcription-quantitative PCR Finally, examined antibacterial effects against intracellulare (M.i.) M.i.-infected macrophages, revealing exerted strongest effect. Collectively, these findings indicate mannose-receptor-targeted delivery be in treating diseases. Accordingly, this system can used target variety cancers immune cells.
Language: Английский
Citations
9
Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 109914 - 109914
Published: April 1, 2024
Language: Английский
Citations
4
ACS Nano, Journal Year: 2024, Volume and Issue: 18(41), P. 28228 - 28245
Published: Oct. 5, 2024
Sepsis-associated encephalopathy (SAE) is a devastating complication of sepsis, affecting approximately 70% patients with sepsis in intensive care units (ICU). Although the pathophysiological mechanisms remain elusive, typically accompanied by systemic inflammatory response syndrome (SIRS) and hyper-oxidative conditions. Here, we introduce biomimetic nanomodulator (mAOI NP) that specifically targets inflammation site simultaneously regulates oxidative stresses. mAOI NPs are constructed using metal-coordinated polyphenolic antioxidants (tannic acid) flavonoid quercetin, which then coated macrophage membrane to enhance pharmacokinetics enable SAE targeting. In cecal ligation puncture (CLP)-induced severe model, effectively mitigate stress purging reactive oxygen species, repairing mitochondrial damage activating Nrf2/HO-1 signaling pathway; while polarizing M1 macrophages or microglia toward anti-inflammatory M2 subtype. potently inhibit progress, prolong overall survival from 25 66% learning memory capabilities mice. Further proteomics analysis reveals modulate neurodevelopment processes related formation also exerting antioxidative effects on brain tissue responses associated pathology. This study offers significant potential for improving patient outcomes revolutionizing treatment landscape this sepsis.
Language: Английский
Citations
4
Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 24, 2025
Language: Английский
Citations
0
Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123169 - 123169
Published: Feb. 5, 2025
Language: Английский
Citations
0
Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Acute lung injury (ALI) is a life-threatening condition characterized by rapidly progressing respiratory distress and hypoxemia. Oxidative stress-induced inflammation in tissue plays crucial role the progression of ALI. Excessive generation reactive oxygen species (ROS) pulmonary microenvironment activates inflammatory signaling pathways, enhancing transcription pro-inflammatory factors ultimately leading to necrosis. Bilirubin (BR), an exceptional endogenous antioxidant, possesses ability counteract elevated levels through direct reactions or inducing antioxidant systems such as Nrf2/HO-1 signaling. However, its limited solubility poses hindrance further applications. Hence, it imperative develop suitable bilirubin-based system for biological utilization. In this study, we developed ROS-sensitive adaptive nanoscavenger (GP@BR) co-assembling bilirubin-conjugated glycol chitosan (GC-BR) polyethylene (PEG-BR), aiming alleviate oxidative stress ALI treatment. The different conjugations endowed bilirubin derivatives with varying sensitivity towards reacting ROS, enabling GP@BR exert antioxidative properties specifically environments on demand. Besides excellent properties, also demonstrated absorb excess cytokines. Moreover, our optimized facilitated transport across mucosal layer epithelial cells. vivo studies confirmed that significantly improved symptoms suppressed fibrosis. This study highlighted potential multiple actions treatment
Language: Английский
Citations
0
Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown
Published: April 3, 2025
Language: Английский
Citations
0
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 8, 2025
Abstract The hypoxic microenvironment and radioresistance of tumor cells, as well the delay in efficacy evaluation, significantly limit effect clinical radiotherapy. Therefore, developing effective radiosensitizers with monitoring response is great significance for precise Herein, a novel radiosensitizer (term as: SCuFs) developed, consisting traditional Chinese medicine (TCM) compounds salidroside, Cu 2+ , hydroxyl radical (•OH) activated second near‐infrared window fluorescence (NIR‐II FL) molecules, which make radiosensitization boosted chemodynamic therapy (CDT) efficacy. overexpressed glutathione induces SCuFs dissociation, allowing deep penetration drug to whole region. After X‐ray irradiation, salidroside inhibits Nuclear factor erythroid 2‐like 2 (Nrf2)protein expression blocks cells G2/M phase highest radiosensitivity, amplifies reactive oxygen species (ROS) generation exacerbate DNA damage, thus achieving radiosensitization. Meanwhile, upregulated ROS provides sufficient chemical fuel + ‐mediated CDT produce more •OH. NIR‐II FL imaging can monitor •OH changes during process, confirming process related This study not only achieves cascaded ROS‐mediated efficacy, but also useful tool therapeutic showing prospects application.
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: May 16, 2024
Testicular torsion is a critical urologic condition for which testicular detorsion surgery considered irreplaceable as well the golden method of reversal. However, surgical treatment equivalent to blood reperfusion process, and no specific drugs are available treat injuries. Salidroside (SAL) one main effective substances in rhodiola, has been shown have antioxidant antiapoptosis activities. This study was designed determine whether SAL exerted protective effect on ischemia-reperfusion (I/R) injury. In this study, I/R injury model testes reoxygenation (OGD/R) were used verification, administered at doses 100 mg/kg 0.05 mmol/L, respectively. After experiments, tissue TM4 Sertoli cells collected histopathologic biochemical analyses. The results revealed that improves structure regulates oxidation–antioxidation system. To further understand molecular mechanisms treating injuries, transcriptomics metabonomics analyses integrated. show Nfr2/HO-1/GPX4/ferroptosis signaling pathway enriched significantly, indicating it may be regulatory Thereafter, transfection with Nrf2 plasmid–liposome reverse verify anti-testicular treatment. Thus, suggested can protect against injuries by regulating Nfr2/HO-1/GPX4 inhibit ferroptosis potential drug
Language: Английский
Citations
1