Biomedical applications of NIR-II organic small molecule fluorescent probes in different organs

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 519, P. 216122 - 216122

Published: Aug. 6, 2024

Language: Английский

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The Midas Touch by Iridium: A Second Near-Infrared Aggregation-Induced Emission-Active Metallo-Agent for Exceptional Phototheranostics of Breast Cancer

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: 147(2), P. 2010 - 2020

Published: Jan. 7, 2025

Developing small organic molecular phototheranostic agents with second near-infrared (NIR-II) aggregation-induced emission (AIE) is paramount for the phototriggered diagnostic imaging and synchronous in situ therapy of cancer via an excellent balance excited states energy dissipations. In this study, a multifunctional iridium(III) complex exploited by coordination AIE-active N^N ancillary ligand trivalent iridium ion. The resultant DPTPzIr significantly outperforms its parent terms absorption/emission wavelengths, reactive oxygen species (ROS) production, photothermal conversion, which simultaneously endow nanoparticles matched absorption peak to commercial 808 nm laser, longest NIR-II (above 1100 nm) among those previously reported AIE complexes, potentiated type-I ROS generation, as high 60.5% conversion efficiency. Consequently, perform well multimodal image-guided photodynamic therapy-photothermal breast tumor-bearing mice, enabling precise tumor diagnosis complete ablation biocompatibility. Our present work provides simple, feasible, effective paradigm development advanced agents.

Language: Английский

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Electron-Withdrawing Substituents Enhance the Type I PDT and NIR-II Fluorescence of BODIPY J Aggregates for Bioimaging and Cancer Therapy

Nano Letters, Journal Year: 2024, Volume and Issue: 24(27), P. 8287 - 8295

Published: June 28, 2024

Organic dyes with simultaneously boosted near-infrared-II (NIR-II) fluorescence, type I photodynamic therapy (PDT), and photothermal (PTT) in the aggregate state are still elusive due to unclear structure-function relationship. Herein, electron-withdrawing substituents introduced at 5-indolyl positions of BODIPY form tight J-aggregates for enhanced NIR-II fluorescence PDT/PTT. The introduction an electron-rich julolidine group

Language: Английский

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Facilely Achieving Near-Infrared-II J-Aggregates through Molecular Bending on a Donor–Acceptor Fluorophore for High-Performance Tumor Phototheranostics

ACS Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

Constructing J-aggregated organic dyes represents a promising strategy for obtaining biomedical second near-infrared (NIR-II) emissive materials, as they exhibit red-shifted spectroscopic properties upon assembly into nanoparticles (NPs) in aqueous environments. However, currently available NIR-II J-aggregates primarily rely on specific molecular backbones with intricate design strategies and are susceptible to fluorescence quenching during assembly. A facile approach constructing bright using prevalent donor-acceptor (D-A) molecules is still lacking. In this study, we present method that transforms D-A by simply bending the molecule through introducing methyl group, enabling high-performance phototheranostics. The TAA-BT-CN exhibits hypsochromic-shift absorption forming H-aggregated NPs, while designed mTAA-BT-CN bent structure demonstrates bathochromic shift of over 100 nm leading much enhanced emission beyond 1100 nm. With respect its counterpart aggregation-caused (ACQ) phenomenon, NPs 7-fold increase owing their aggregation-induced (AIE) property well efficient generation heat reactive oxygen species under 808 light excitation. Finally, employed whole-body blood vessel imaging technology imaging-guided tumor phototherapies. This study will facilitate flourishing advancement based D-A-type molecules.

Language: Английский

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Intraoperative Resection Guidance and Rapid Pathological Diagnosis of Osteosarcoma using B7H3 Targeted Probe under NIR‐II Fluorescence Imaging

Advanced Science, Journal Year: 2024, Volume and Issue: 11(33)

Published: March 19, 2024

Complete removal of all tumor tissue with a wide surgical margin is essential for the treatment osteosarcoma (OS). However, it's difficult, sometimes impossible, to achieve due invisible small satellite lesions and blurry boundaries. Besides, intraoperative frozen-section analysis resection margins OS often restricted by hard tissues around OS, which makes it impossible know whether negative achieved. Any unresected residuals will lead local recurrence worse prognosis. Herein, based on high expression B7H3 in targeted probe B7H3-IRDye800CW synthesized conjugating anti-B7H3 antibody IRDye800CW. can accurately label areas after intravenous administration, thereby helping surgeons identify resect residual (<2 mm) lung metastatic lesions. The tumor-background ratio reaches 4.42 ± 1.77 at day 3. After incubating fresh human specimen B7H3-IRDye800CW, specifically area even microinvasion (confirmed hematoxylin-eosin [HE] staining). labeled consistent shown magnetic resonance imaging complete HE staining specimen. In summary, has translational potential guidance rapid pathological diagnosis OS.

Language: Английский

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Small Organic Molecules-based NIR Agents in Cancer Diagnostics: New Frontiers in Imaging and Therapy

Dyes and Pigments, Journal Year: 2025, Volume and Issue: unknown, P. 112648 - 112648

Published: Jan. 1, 2025

Language: Английский

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Fully Inter-restricted Assembly of Aggregation-Induced Emission Luminogens and Polymers Enables Ultra-bright Nanoparticles for Sensitive Point-of-Care Diagnosis

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Fluorescent lateral flow immunoassay (LFIA) is recognized as a leading quantitative point-of-care (POC) platform for precise clinical diagnostics. However, conventional fluorescent nanoprobes are hampered by low quantum yield (QY), which constrain the sensitivity of LFIA. Herein, we employed butterfly aggregation-induced emission luminogen (AIEgen) and developed fully inter-restricted assembly with polyphenyl polymer poly(maleicanhydride-styrene) (PMPS) to create highly homogeneous nanoparticles (ho-AIENPs) QY over 91%. Compared core-shell heterostructure (he-AIENPs), ho-AIENPs demonstrate structure AIEgens uniformly dispersed in PMPS matrix nanoparticles. The robust broad intermolecular interaction (e.g., π-π interactions) between effectively restricts molecular motion AIEgens, producing 30% increase than he-AIENPs. Ho-AIENPs exhibit 5-fold 80-fold improved compared traditional he-AIENP-based LFIAs AuNP-based colorimetric LFIAs. Owing excellent optical properties ho-AIENPs, ho-AIENP-based multiplex LFIAs, can simultaneously detect lung cancer biomarkers exceptionally high sensitivity. In contrast physical encapsulation strategies, strategy promising, versatile, efficient enhancing matrix-derived particles sensitizing immunoassays.

Language: Английский

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Enhancing the fluorescence emission of the NIR-II fluorophores: Strategies, mechanisms, challenges, and opportunities

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 532, P. 216511 - 216511

Published: Feb. 21, 2025

Language: Английский

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Near-infrared theranostics for brain diseases: Design, engineering, and emerging applications

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 534, P. 216591 - 216591

Published: March 9, 2025

Language: Английский

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Self-Assembly versus Coassembly: An Amphiphilic NIR-II Aggregation-Induced Emission Luminogen for Phototheranostics of Orthotopic Glioblastoma

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 13, 2025

Glioblastoma (GBM) is the most lethal form of malignant brain tumor, known for its high infiltration, aggressiveness, and poor prognosis. Second near-infrared (NIR-II, 1000-1700 nm) phototheranostic agents bring intriguing opportunities GBM management owing to their noninvasive nature, controllability, deeper tissue penetration. Herein, an amphiphilic NIR-II luminogen (PEG-TD) with aggregation-induced emission (AIE) characteristics, along hydrophobic counterpart (C6-TD), was meticulously synthesized. Specifically, PEG-TD nanoparticles (NPs), formed through straightforward self-assembly, exhibited superior stability, simplicity, robust reactive oxygen species production efficiency, excellent photothermal conversion compared C6-TD NPs, which were fabricated via coassembly DSPE-mPEG, primarily attributed distinct molecular arrangements within forming aggregates. The inherent advantages NPs led significant therapeutic efficacy against GL261 cells under 808 nm laser irradiation. Eventually, fluorescence/photothermal duplex imaging-guided combined photodynamic/photothermal therapy successfully performed in orthotopic glioblastoma mouse model minimal adverse effects.

Language: Английский

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