Dual-Enzyme-Instructed Peptide Self-Assembly to Boost Immunogenic Cell Death by Coordinating Intracellular Calcium Overload and Chemotherapy

ACS Nano, Journal Year: 2025, Volume and Issue: 19(1), P. 488 - 503

Published: Jan. 4, 2025

The concept of immunogenic cell death (ICD) induced by chemotherapy as a potential synergistic modality for cancer immunotherapy has been widely discussed. Unfortunately, most chemotherapeutic agents failed to dictate effective ICD responses due their defects in inducing potent signaling. Here, we report dual-enzyme-instructed peptide self-assembly platform CPMC (CPT-GFFpY-PLGVRK-Caps) that cooperatively utilizes camptothecin (CPT) and capsaicin (Caps) promote engage systemic adaptive immunity tumor rejection. Although CPT Caps respectively prevent progression inhibiting type-I DNA topoisomerase activating transient receptor cation channel subfamily V member 1 (TRPV1) intracellular calcium overload, neither alone effectively stimulates sufficient signaling meet immunotherapeutic needs. CPMC, sequentially allowing an active derivative VRK-Caps release extracellularly intracellularly, can synergize two distinct apoptosis pathways stimulated increase immunogenicity elicit T-cell-based immunity. Consequently, facilitates the generation improved tumor-specific cytotoxic T-cell sustained immunological memory, successfully suppressing both primary distant tumors. Moreover, render tumors susceptible PD-L1 blockade with antiprogrammed death-ligand (aPDL1) antibody inhibition. Combining drugs low ICD-stimulating capacity using strategy was demonstrated boost potentiate immunotherapy.

Language: Английский

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Homologous-adhering/targeting cell membrane- and cell-mediated delivery systems: a cancer-catch-cancer strategy in cancer therapy

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 12

Published: Nov. 20, 2024

Abstract Low tumor enrichment remains a serious and urgent problem for drug delivery in cancer therapy. Accurate targeting of sites is still critical aim Though there have been variety strategies to improve the enrichment, biological barriers cause most delivered guests fail or be excreted before they work. Recently, cell membrane-based systems attracted huge amount attention due their advantages such as easy access, good biocompatibility immune escape, which contribute biomimetic structures specific surface proteins. Furthermore, are referred homologous-targeting function exhibit significantly high adhesion internalization homologous-type cells even though exact mechanism not entirely revealed. Here, we summarize sources characterizations membrane systems, including reconstructed single hybrid nano-/microcarriers, well engineered cells. Additionally, advanced applications these therapy categorized summarized according components membranes. The potential factors related homologous also discussed. By discussing applications, challenges opportunities, expect far-reaching development preclinic clinics.

Language: Английский

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Biomimetic Nanomaterials Based on Peptide In Situ Self‐Assembly for Immunotherapy Applications

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 1, 2025

ABSTRACT Cancer remains the leading cause of patient death worldwide and its incidence continues to rise. Immunotherapy is rapidly developing due significant differences in mechanism action from conventional radiotherapy targeted antitumor drugs. In past decades, many biomaterials have been designed prepared construct therapeutic platforms that modulate immune system against cancer. Immunotherapeutic utilizing can markedly enhance efficacy by optimizing delivery agents, minimizing drug loss during circulation, amplifying immunomodulatory effects. The intricate physiological barriers tumors, coupled with adverse environments such as inadequate infiltration, off‐target effects, immunosuppression, emerged obstacles impeding effectiveness oncology therapy. However, most current studies are devoted development complex immunomodulators exert functions loading drugs or adjuvants, ignoring tumors. Compared biomaterials, biomimetic nanomaterials based on peptide situ self‐assembly excellent functional characteristics biocompatibility, biodegradability, bioactivity a novel effective tool for cancer immunotherapy. This article presents comprehensive review latest research findings tumor Initially, we categorize structural types elucidate their intrinsic driving forces. Subsequently, delve into strategies these nanomaterials, highlighting advantages Furthermore, detail applications antigen presentation modulation microenvironment. conclusion, encapsulate challenges prospective developments clinical translation

Language: Английский

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In situ polymer synthesis within living systems for cancer immunotherapy

Published: April 1, 2025

Language: Английский

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Peptide-harnessed supramolecular and hybrid nanomaterials for stimuli-responsive theranostics

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 539, P. 216737 - 216737

Published: May 1, 2025

Language: Английский

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