Advancing Tumor Vaccines: Overcoming TME Challenges, Delivery Strategies, and Biomaterial-based Vaccine for Enhanced Immunotherapy DOI
Qingsong Zeng, Shibo Zhang, Ning Leng

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: unknown, P. 104576 - 104576

Published: Nov. 1, 2024

Language: Английский

Preclinical advance in nanoliposome-mediated photothermal therapy in liver cancer DOI Creative Commons
Le Tang, Xiao Yang, Liwen He

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 31, 2025

Language: Английский

Citations

2
Lung‐Specific mRNA Delivery by Ionizable Lipids with Defined Structure‐Function Relationship and Unique Protein Corona Feature DOI Creative Commons
Xiaoyan He, Rui Wang,

Yan Cao

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Abstract Targeted delivery of mRNA with lipid nanoparticles (LNPs) holds great potential for treating pulmonary diseases. However, the lack rational design principles efficient lung‐homing lipids hinders prevalence therapeutics in this organ. Herein, combinatorial screening structure‐function analysis is applied to rationalize strategy nonpermanently charged lung‐targeted ionizable lipids. It discovered that carrying N‐methyl and secondary amine groups heads, three tails originated from epoxyalkanes, exhibiting superior selectivity efficiency. Representative systematically variation chemical structures are selected study well‐known but still puzzling “protein corona” adsorbed on surface LNPs. In addition commonly used corona‐biomarker vitronectin, other arginine‐glycine‐aspartic acid (RGD)‐rich proteins usually involved collagen‐containing extracellular matrix, such as fibrinogen fibronectin have also been identified a strong correlation lung tropism. This work provides insight into lung‐targeting reveals previously unreported function RGD‐rich protein corona

Language: Английский

Citations

1
Methionine-Based Sulfonium Lipid Mediates dsRNA for Gene Silencing in Pests DOI
Jing Li,

Wenyang Chen,

Yue Lin

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Effective gene carriers will promote the application of RNA interference (RNAi) technology in future pesticide development. This paper reports a group novel methionine-based sulfonium lipid compounds (MSLs) and screens their delivery abilities vitro vivo. Experiments showed that most MSLs could encapsulate nucleic acids into nanoparticles at an S/P ratio 4:1, with nanoparticle sizes ranging from 124 to 216 nm zeta potentials +27 40 mV, effectively protect enzymatic degradation. successfully mediated cellular uptake transfection Kc cells insects. Using dsRNA CHT10 as RNAi target, four were proven mediate Drosophila melanogaster Ostrinia furnacalis achieved significant growth inhibition during larval development, eventually leading pest death. The study demonstrates are useful nanocarriers for development pesticides.

Language: Английский

Citations

0
Design and Evaluation of Methionine Based Sulfonium Lipid for Nucleic Acid Delivery DOI
Jing Li,

Yue Lin,

Xinrui Bi

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106956 - 106956

Published: April 1, 2025

Language: Английский

Citations

0
Non-viral mRNA delivery to the lungs DOI Creative Commons

Lauren Healy,

B. Seto,

Haissi Cui

et al.

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review highlights emerging strategies for lung-targeted mRNA delivery using non-viral vehicles, describing advances in bioinspired design and nanoparticle engineering.

Language: Английский

Citations

0
Predictive Lung- and Spleen-Targeted mRNA Delivery with Biodegradable Ionizable Lipids in Four-Component LNPs DOI Creative Commons

Juan Heredero,

Álvaro Peña, Esther Broset

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 459 - 459

Published: April 2, 2025

Background/Objectives: Lipid nanoparticles (LNPs) are leading mRNA delivery vehicles, with ionizable lipids (ILs) as their key component. However, the relationship between IL structure and LNP endogenous organ-targeting is not well understood. In this study, we developed a novel library of biodegradable ILs featuring beta-propionate linkers, which, when incorporated into four-component formulation, show excellent extrahepatic selectivity high protein expression. Methods: We explored impact structural modifications in hydrophobic chains polar-head groups while keeping linkers unchanged. vivo results were evaluated to examine how changes influence biodistribution spleen or lungs. formulations assessed for expression levels organ-specific targeting. Additionally, corona formation by best-performing LNPs was examined provide further mechanistic insights. Results: Organ targeting significantly influenced ILs, allowing precise control Branched demonstrated higher propensity targeting, group could drastically shift from lung spleen. This led identification LNPs’ zeta potential determinant properties. Notably, lipid A3T2C7, also known CP-LC-1495, displayed strong (97%) tissue (1.21 × 108 p/s). Similarly, several promising candidates spleen-targeting exceeding 1 107 p/s (selectivity >80%). Conclusions: study elucidates structure–function relationships passive delivery, highlighting fine-tuning chains, groups, surface charge (zeta potential) allows biodistribution, mechanism formation. These findings enable rational design targeted systems, enhancing therapeutic specific organs, such

Language: Английский

Citations

0
Advancing Tumor Vaccines: Overcoming TME Challenges, Delivery Strategies, and Biomaterial-based Vaccine for Enhanced Immunotherapy DOI
Qingsong Zeng, Shibo Zhang, Ning Leng

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: unknown, P. 104576 - 104576

Published: Nov. 1, 2024

Language: Английский

Citations

0