Dynamic Hyaluronic Acid Hydrogels for Comprehensively Regulating Inflammation, Angiogenesis, and Metabolism to Effectively Proheal Diabetic Wounds DOI

Yanzheng Chen,

Qing Wang,

Fangrui Ning

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(51), P. 70256 - 70273

Published: Dec. 13, 2024

Despite the great progress of various multifunctional wound dressings, it is challenging to simultaneously achieve complete healing and functional remodeling for diabetic foot ulcers refractory chronic wounds. Aiming comprehensively regulate inflammation, angiogenesis, metabolism processes, herein, a novel kind dynamic hyaluronic acid (HA) hydrogel was designed by combining boronate coordination chemistry. Besides having injectability, self-healing, detachment properties, HA hydrogels presented wound-responsive degradation controllable H2S release. They could efficiently polarize M1-to-M2 polarization inflammatory cytokine secretion multiple inflammation-related mRNA expressions through cooperative actions reactive oxygen species elimination + release Zn2+ regulation, thus driving inflammation into proliferation stages. Moreover, screened lead HTZS angiogenesis-related signaling pathways processes promote neovascularization mature vessel formation, re-epithelization, high-level collagen-I deposition, dense hair follicle regeneration, achieving in Importantly, this work opens new avenue design biopolymer high-performance dressing decipher key role orchestrated regulations inflammation–angiogenesis–metabolism on

Language: Английский

Zn-DHM nanozymes regulate metabolic and immune homeostasis for early diabetic wound therapy DOI
Shuo Zhang, Xinyu Zhao, Wei Zhang

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 49, P. 63 - 84

Published: March 6, 2025

Language: Английский

Citations

3
ZnCur nanoparticle-enhanced multifunctional hydrogel platform: Synergistic antibacterial and immunoregulatory effects for infected diabetic wound healing DOI
Yanwen Ding, Zhiwei Zhang, Xinyu Cui

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 158387 - 158387

Published: Dec. 1, 2024

Language: Английский

Citations

9
Biomolecular Microneedle Initiates Fe3O4/MXene Heterojunction‐Mediated Nanozyme‐Like Reactions and Bacterial Ferroptosis to Repair Diabetic Wounds DOI Creative Commons
Wenjie You,

Zichao Cai,

Feng Xiao

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Reactive oxygen species (ROS) play a dual role in wound healing. They act as crucial signaling molecules and antimicrobial agents when present at moderate levels. However, excessive levels of ROS can hinder the healing process for individuals with diabetes. As result, targeting to maintain redox balance has become promising strategy improving recovery. Currently, no biomaterials have been reported simultaneously up-regulate down-regulate achieve broad-spectrum antibacterial antioxidant properties. Inspired by site-dependent effect nanomaterials, micron-sized ferroferric oxide (Fe3O4)/MXene (FM) heterojunction is synthesized using hydrothermal method. The FM could scavenge extracellular activating catalase (CAT)-like superoxide dismutase (SOD)-like nanozyme activities. Meanwhile, release ferric ions ferrous defect engineering induce bacterial ferroptosis, up-regulating intercellular ROS, lipid peroxidation. For applications vivo, incorporated into tips gelatin methacryloyl (GelMA)-based microneedle (termed GFM microneedle) two-step casting technique. results showed that combined photothermal therapy improve S. aureus-infected skin regeneration diabetic rats. effectiveness safety are not less favorable than commercial dressing. This study provides proof-of-concept heterojunction-mediated regenerative medicine via ROS-targeting strategy.

Language: Английский

Citations

1
Bioinspired programmed antibiofilm strategies for accelerated wound healing via spatiotemporally controlled enzyme nanoreactors DOI
Juntao Hu,

Yibing Huang,

Hao Hao

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113582 - 113582

Published: March 1, 2025

Language: Английский

Citations

1
Hierarchical Integration of Curcumin‐Loaded CaCO3 Nanoparticles and Black Phosphorus Nanosheets in Core/Shell Nanofiber for Cranial Defect Repair DOI Open Access
Yan Zheng, Lu Tan, Hang Chen

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

Abstract Reconstruction and healing of large craniofacial bone defects are major clinical challenges due to high risk chronic inflammation reduced cell mineralization levels. Herein, a core‐shell nanofiber‐based implant with significant pro‐osteogenesis capability for treating skull is reported, which hierarchically integrated curcumin‐loaded calcium carbonate nanoparticles (CaCO 3 @Cur NPs) in the outer layers black phosphorus nanosheets (BPNSs) core compartments. The radical alignment nanocomponents allows sequential situ release therapeutic agents controlled manner after implantation. Curcumin can repolarize M1 macrophages into M2 phenotypes anti‐inflammation purposes. Meanwhile, released phosphate ions promote biomineralization hydroxyapatite at defect site facilitate regeneration. Evaluations on cranial defect‐bearing rat models demonstrated that electrospun fibers present study substantially promoted restoration damaged skulls inhibited wound bed. This strategy provides new idea treatment clinic.

Language: Английский

Citations

3
An antioxidant, antibacterial, and immunoregulatory konjac glucomannan-based nanocomposite hydrogel for promoting skin wound healing DOI
Zixuan Zhao, Yuke Wang,

Liyang Jia

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141791 - 141791

Published: March 1, 2025

Language: Английский

Citations

0
Acid-responsive aggregated carrot-derived nanoantioxidants alleviate oxidative stress and restore osteoblast activity DOI Creative Commons
Jiao Peng, Rongyan Liu, Junyi Xu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 12, 2025

Excessive generation of reactive oxygen species is a hallmark the osteoporotic bone microenvironment, which leads to damage mitochondrial function and deactivation osteoblasts. Fruits vegetables are rich sources antioxidants, play key role in scavenging free radicals maintaining body's homeostasis. Herein, we have developed type vesicle coming from carrots as nanoantioxidants counteract oxidative stress restore vitality osteoblasts for reversing osteoporosis. Nanovesicles derived carrot juice using straightforward extrusion method, resulting stable membrane structures containing various lipids homologous active phytochemicals. can maintain under normal physiological conditions (pH 7.4) transform into aggregates response acidic extracellular pH osteoporosis 4.0). As anticipated, nanovesicles passively target aggregate bone, ease stress, function, promote osteoblastogenesis, reduce loss mice. This work presents first demonstration novel realize long-awaited osteogenesis, contributing exploration brand-new idea

Language: Английский

Citations

0
Application of sodium alginate and polyethylene glycol bilayer multifunctional hydrogel microneedles in infectious and diabetic wounds DOI

Bao Hou,

Anjing Xu,

Shijie Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143471 - 143471

Published: April 1, 2025

Language: Английский

Citations

0
Chitosan and polyvinyl alcohol-based bilayer electrospun nanofibrous membrane incorporated with astaxanthin promotes diabetic wound healing by addressing multiple factors DOI

Yuhang Zhan,

Huixuan Sun,

Zhihan Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 311, P. 143921 - 143921

Published: May 3, 2025

Language: Английский

Citations

0
Injectable Spiky Artificial Peroxidase‐Encapsulated Hydrogels for Bioadaptively and Synergistically Combating Endometrial Infections DOI
Yu Jiang, Zhongwei Ding, Tian Ma

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Abstract Endometrial infections can lead to acute endometritis and persistent inflammation of the uterus, which may further infertility in severe cases. It is a great challenge develop localized antimicrobial therapeutic strategy that exploits infected microenvironment for effectively combating endometrial facilitating repair. Here, an injectable spiky artificial Cu‐polyphthalocyanine peroxidase‐encapsulated thermosensitive hydrogel engineered bioadaptively synergistically infection. The comprehensive investigations have elucidated network‐based spike‐linked enzyme‐mimics (SLE‐CuPPc) possess dual functionalities nanostructure enables efficient capture kill action bacteria simultaneously generates substantial quantity reactive oxygen species (ROS). attachment SLE‐CuPPc bacterial surfaces constricts ROS radius, thereby potentiating its bactericidal efficacy. encapsulated into clinically approved hydrogel, yielding composite G‐SLE‐CuPPc. infection models demonstrate this formulation not only eradicates S. aureus but also stimulates vascular proliferation, curbs fibrosis, fosters This work demonstrates pivotal role G‐SLE‐CuPPc eradicating antibiotic‐resistant paves way developing next‐generation hydrogels clinical treatment.

Language: Английский

Citations

0