Molecular Engineering‐Boosted High‐Performance AIE Sonosensitizer for Cancer Sonodynamic‐Augmented Immunotherapy

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

ABSTRACT Immunogenic cell death (ICD) has been demonstrated as a reliable approach to improve therapeutic effect in cancer treatment by triggering antitumor immunity. However, the trigger of ICD on basis chemotherapy and phototherapy meets obstacles serious side poor penetration ability, which seriously impedes effect. The development sonodynamic immunotherapy with evoking presents high promise for efficacy. Herein, performance aggregation‐induced emission (AIE) sonosensitizer is constructed engineering structure modulation sonodynamic‐augmented immunotherapy. By regulating intermolecular interaction pull‐push electronic effect, bearing AIE feature amplified sono‐sensitizing developed. In addition, vitro observation that thiolate‐substituted segment incorporation endows molecules enhanced cellular uptake efficiency improved tumor eradication ability. More importantly, developed could efficiently evoke upon ultrasound, allows efficient both at level solid tumor. inhibition primary further boost systemic immunity response complete elimination toward distant achieved. investigation highlights utilizing sonosensitizers conquer current limitation treatment.

Language: Английский

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Tumor-microenvironment-mediated second near-infrared light activation multifunctional cascade nanoenzyme for self-replenishing O2/H2O2 multimodal tumor therapy

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 683, P. 930 - 943

Published: Dec. 30, 2024

Language: Английский

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Applications of Nanotheranostic in the Second Near-Infrared Window in Bioimaging and Cancer Treatment

Nanoscale, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Achieving accurate and efficient tumor imaging is crucial in the field of treatment, as it facilitates early detection precise localization tissues, thereby informing therapeutic strategies surgical interventions. The optical technology within second near-infrared (NIR-II) window has garnered significant interest for its remarkable benefits, such enhanced tissue penetration depth, superior signal-to-background ratio (SBR), minimal autofluorescence, reduced photon attenuation, lower scattering. This review explained design optimization nano-agents responsive to NIR-II window, single-walled carbon nanotubes, quantum dots, lanthanum-based nanomaterials, noble metal nanomaterials. These enable non-invasive, deep-tissue with high spatial resolution their properties significantly improve accuracy, efficiency, versatility imaging-guided treatments. And we discussed characteristics advantages fluorescence (FL)/photoacoustic (PA) providing a comprehensive overview latest research progress different FL/PA therapy. Furthermore, exhaustively reviewed applications multifunctional nano-phototherapy technologies carried out by light including photothermal therapy (PTT), photodynamic (PDT), combined modalities like photothermal-chemodynamic (PTT-CDT), photothermal-chemotherapy (PTT-CT), photothermal- immunotherapy (PTT-IO). integrated approaches have gradually matured over past decade are expected become safe effective non-invasive treatment. Finally, outlined prospects challenges development innovation diagnosis nanoplatform. aims provide insightful perspectives future advancements treatment platforms.

Language: Английский

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Strain-dependent interface barriers and photoresponse characteristics of MoSe2 monolayer flexible devices based on piezotronic and piezophototronic effects

Nano Energy, Journal Year: 2024, Volume and Issue: unknown, P. 110618 - 110618

Published: Dec. 1, 2024

Language: Английский

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