Nanomaterials in the diagnosis and treatment of gastrointestinal tumors: New clinical choices and treatment strategies

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101782 - 101782

Published: April 19, 2025

Language: Английский

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Ultrasound‐Activated Precise Sono‐Immunotherapy for Breast Cancer with Reduced Pulmonary Fibrosis

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Abstract Immune checkpoint inhibitors have demonstrated remarkable efficacy across various cancer types. However, immune‐related adverse events (irAEs) pose a significant challenge in immunotherapy, particularly the associated pneumonia as primary reaction, which can lead to irreversible pulmonary fibrosis. Additionally, monotherapy with programmed death ligand (PD‐L1) has shown limited effectiveness. Therefore, improve response rate of immunotherapy and reduce fibrosis, this study designed prepared an intelligent nanodrug based on dendritic mesoporous silica nanoparticles (DMSNs) loaded sono‐sensitive agent protoporphyrin IX (PpIX). reactive oxygen species (ROS) sensitive linker is used attach immunotherapeutic drug PD‐L1 inhibitor (aPD‐L1) DMSNs via covalent bonds. The external ultrasound (US) activates PpIX generate ROS, breaks release aPD‐L1 induce sonodynamic therapy (SDT) immunotherapy. This sono‐immnotherapy approach excellent outcomes tumor inhibition, eliciting immune responses, reducing Overall, offers new, efficient, safe method for breast treatment, expands application

Language: Английский

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Innovative applications and research progress of hepatic arterial infusion chemotherapy in the treatment of advanced hepatocellular carcinoma

World Journal of Gastrointestinal Oncology, Journal Year: 2025, Volume and Issue: 17(2)

Published: Jan. 18, 2025

This article provides an in-depth analysis of the study conducted by Wang et al, which explores hepatic arterial infusion chemotherapy and its synergistic strategies in managing advanced hepatocellular carcinoma (HCC). HCC ranks as fourth most common cause cancer-related mortality globally is frequently associated with portal vein tumor thrombus (PVTT). The approach to HCC, particularly when PVTT present, diverges markedly between Eastern Western practices. These differences are rooted variations epidemiology, etiology, pathology, comorbidities, prognosis. paper delves into diagnosis, classification, treatment for PVTT, well evolving role advancements therapeutic landscape HCC.

Language: Английский

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Pt–PtTe₂ Nanoparticles with Heterojunction-Based Accelerated Electron Transfer for Efficient Tumor Therapy

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Language: Английский

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Nanoconfined heterojunctions with enhanced piezoelectricity for amplifying reactive oxygen species storms-triggered tumor ferroptosis-like/apoptosis

Nano Today, Journal Year: 2025, Volume and Issue: 64, P. 102785 - 102785

Published: May 5, 2025

Language: Английский

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Cascade‐amplified Oxidative Stress via Bandgap‐Tuned KBiO₃ Perovskite for Cancer Therapy

Small, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Abstract Sonodynamic therapy (SDT) is a promising cancer treatment due to its ability utilize ultrasound (US) activate sonosensitizers, generating reactive oxygen species (ROS) for tumor suppression. High‐valence bismuth, known unique photoacoustic properties and biocompatibility, has shown great potential when combined with SDT. However, conventional sonosensitizers large bandgaps electron‐hole recombination have limited SDT's effectiveness. Herein, bismuth‐based piezoelectric sonosensitizer developed, DSPE‐PEG 2000‐modified KBiO 3 (KBP), which features reduced bandgap (1.9 eV). This facilitates electron transfer depletes glutathione in the microenvironment. Under US, KBP generates significant amount of ROS, leading cell pyroptosis via ROS‐NLRP3‐Caspase‐1‐GSDMD pathway. Both vitro vivo experiments demonstrated that SDT can effectively inhibit growth. research offers novel approach by leveraging advantages SDT, demonstrating clinical inhibition.

Language: Английский

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Amplifying Ca2+ Overload by Engineered Biomaterials for Synergistic Cancer Therapy

Biomaterials, Journal Year: 2024, Volume and Issue: 316, P. 123027 - 123027

Published: Dec. 15, 2024

Language: Английский

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