Novel Peptide-Modified Zeolitic Imidazolate Framework-8 Nanoparticles with pH-Sensitive Release of Doxorubicin for Targeted Treatment of Colorectal Cancer DOI Creative Commons
Liming Gong, Heming Zhao, Liqing Chen

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 246 - 246

Published: Feb. 13, 2025

Background: Colorectal cancer (CRC) is one of the common malignant tumors. Chemotherapeutic agents represented by doxorubicin (DOX) are adjuvant therapies for patients with advanced CRC. However, DOX suffers from dose-dependent cardiotoxicity and myelosuppression due to a lack targeting specificity, which severely limits its clinical application. Methods: Herein, we constructed zeolitic imidazolate framework-8 (ZIF-8) modified novel peptide (LT peptide) deliver chemotherapeutic drug targeted treatment Results: In this study, LT-PEG@DOX@ZIF-8 nanoparticles were prepared simple method suitable particle size zeta potential, also capable pH-responsive release. vitro assays exhibited that effectively taken up C26 cells, significantly inhibited cell proliferation, induced apoptosis. Furthermore, in mice models colorectal tumors, displayed specific tumor aggregation exerted anti-tumor effects prolong survival mice. Conclusions: conclusion, provides promising strategy delivery treat

Language: Английский

Nanotechnology in healthcare, and its safety and environmental risks DOI Creative Commons
Xiaohan Ma,

Yaxin Tian,

Yang Ren

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 15, 2024

Abstract Nanotechnology holds immense promise in revolutionising healthcare, offering unprecedented opportunities diagnostics, drug delivery, cancer therapy, and combating infectious diseases. This review explores the multifaceted landscape of nanotechnology healthcare while addressing critical aspects safety environmental risks associated with its widespread application. Beginning an introduction to integration we first delved into categorisation various materials employed, setting stage for a comprehensive understanding potential. We then proceeded elucidate diverse applications nanotechnology, spanning medical tissue engineering, targeted gene development antimicrobial agents. The discussion extended current situation surrounding clinical translation commercialisation these cutting-edge technologies, focusing on nanotechnology-based products that have been approved globally date. also discussed considerations nanomaterials, both terms human health impact. presented vivo nanomaterial exposure, relation transport mechanisms, oxidative stress, physical interactions. Moreover, highlighted risks, acknowledging potential implications ecosystems biodiversity. Lastly, strived offer insights regulatory governing across different regions globally. By synthesising perspectives, underscore imperative balancing innovation stewardship, charting path forward responsible healthcare. Graphical abstract

Language: Английский

Citations

35
Design, Current States, and Challenges of Nanomaterials in Anti-Neuroinflammation: A Perspective on Alzheimer’s Disease DOI

Xinyang Hong,

Tongkai Chen, Yunyun Liu

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102669 - 102669

Published: Jan. 1, 2025

Language: Английский

Citations

1
A Biomimetic Mineralization Strategy for the Long‐Term Preservation of Exosomes Through Non‐Destructive Encapsulation Within Zeolite Imidazolate Frameworks‐8 DOI Open Access

Jiaxin Jia,

Deqiang Kong,

Yong Liu

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Abstract Exosomes, which are extracellular vesicles derived from endosomes, play a crucial role in mediating intercellular communication and widely used medical diagnostics drug delivery. Conventional cryopreservation strategies can damage the integrity of exosomes, hindering their further application biomedical field. Here, novel approach is developed for exosome storage, shell intact exosomes holding (SHIELD), packages zeolite imidazolate frameworks‐8 (ZIF‐8) as protective shell. ZIF‐8 be quickly removed, meanwhile, inherent morphology biological function preserved, thereby mitigating potential biocompatible risks associated with ZIF‐8. Notably, SHIELD‐protected maintained cellular uptake capacity, 76% original protein content kept even after being stored one month. Overall, development SHIELD overcomes challenges traditional techniques preservation broadens applications exosomes.

Language: Английский

Citations

1
Core–Shell Nanoparticles with Sequential Drug Release Depleting Cholesterol for Reverse Tumor Multidrug Resistance DOI

Jieke Zhang,

Yingying Zhou,

Jialing Guo

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Multidrug resistance (MDR) facilitates tumor recurrence and metastasis, which has become a main cause of chemotherapy failure in clinical. However, the current therapeutic effects against MDR remain unsatisfactory, mainly hampered by rigid structure drug-resistant cell membranes uncontrolled drug release. In this study, based on sequential release strategy, we engineered core–shell nanoparticle (DOX-M@CaP@ATV@HA) depleting cholesterol for reverse MDR. DOX-M@CaP@ATV@HA could accurately target cells due to active targetability hyaluronic acid (HA) toward CD44 receptors. The calcium phosphate (CaP) shell was cleaved lysosomal acidic environment so that cholesterol-lowering atorvastatin (ATV) rapidly released diminish P-glycoprotein (P-gp) level membrane, thereby boosting uptake. Next, doxorubicin (DOX) gradually from hydrophobic core mPEG-DSPE micelle, inflicting irreversible DNA damage triggering apoptosis. nanosystem proven both vitro vivo effectively exhibited remarkable efficacy tumors with high biosafety. conclusion, reverses via depletion, provides an innovative strategy treatment.

Language: Английский

Citations

0
Novel Peptide-Modified Zeolitic Imidazolate Framework-8 Nanoparticles with pH-Sensitive Release of Doxorubicin for Targeted Treatment of Colorectal Cancer DOI Creative Commons
Liming Gong, Heming Zhao, Liqing Chen

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 246 - 246

Published: Feb. 13, 2025

Background: Colorectal cancer (CRC) is one of the common malignant tumors. Chemotherapeutic agents represented by doxorubicin (DOX) are adjuvant therapies for patients with advanced CRC. However, DOX suffers from dose-dependent cardiotoxicity and myelosuppression due to a lack targeting specificity, which severely limits its clinical application. Methods: Herein, we constructed zeolitic imidazolate framework-8 (ZIF-8) modified novel peptide (LT peptide) deliver chemotherapeutic drug targeted treatment Results: In this study, LT-PEG@DOX@ZIF-8 nanoparticles were prepared simple method suitable particle size zeta potential, also capable pH-responsive release. vitro assays exhibited that effectively taken up C26 cells, significantly inhibited cell proliferation, induced apoptosis. Furthermore, in mice models colorectal tumors, displayed specific tumor aggregation exerted anti-tumor effects prolong survival mice. Conclusions: conclusion, provides promising strategy delivery treat

Language: Английский

Citations

0